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Quantum machine learning algorithms, the extensions of machine learning to quantum regimes, are believed to be more powerful as they leverage the power of quantum properties. Quantum machine learning methods have been employed to solve…

Computational Physics · Physics 2021-06-01 Shree Hari Sureshbabu , Manas Sajjan , Sangchul Oh , Sabre Kais

This work presents the implementation of a fragment-based, quantum-centric supercomputing workflow for computing molecular electronic structure using quantum hardware. The workflow is applied to predict the relative energies of two…

The development of fault-tolerant quantum computers (FTQCs) is receiving increasing attention within the quantum computing community. Like conventional digital computers, FTQCs, which utilize error correction and millions of physical…

Digital quantum computers promise exponential speedups in performing quantum time-evolution, providing an opportunity to simulate quantum dynamics of complex systems in physics and chemistry. However, the task of extracting desired quantum…

Quantum Physics · Physics 2025-03-10 Chong Hian Chee , Daniel Leykam , Adrian M. Mak , Kishor Bharti , Dimitris G. Angelakis

Quantum chemistry has been viewed as one of the potential early applications of quantum computing. Two techniques have been proposed for electronic structure calculations: (i) the variational quantum eigensolver and (ii) the…

Quantum Physics · Physics 2021-04-19 Christina Daniel , Diksha Dhawan , Dominika Zgid , James K. Freericks

We demonstrate the feasibility of quantum computing for large-scale, realistic chemical systems through the development of a new interface using a quantum circuit simulator and CP2K, a highly efficient first-principles calculation software.…

Chemical Physics · Physics 2025-06-24 Tomoya Shiota , Klaas Gunst , Toshio Mori , Toru Shiozaki , Wataru Mizukami

Achieving chemical accuracy for strongly correlated molecules is a defining milestone for first-generation, fault-tolerant quantum computers, yet the factorial growth of three, four, and six-index tensor contractions in coupled-cluster…

Achieving practical quantum advantage on fault-tolerant quantum computers (FTQC) is fundamentally constrained by the substantial spatial and temporal overheads required to map logical operations onto physical hardware. Existing compilation…

Quantum Physics · Physics 2026-05-15 Dhanvi Bharadwaj , Siddharth Dangwal , Yuewen Hou , Gokul Subramanian Ravi

Quantum dynamics compilation is an important task for improving quantum simulation efficiency: It aims to synthesize multi-qubit target dynamics into a circuit consisting of as few elementary gates as possible. Compared to deterministic…

Quantum Physics · Physics 2024-09-26 Yuxuan Zhang , Roeland Wiersema , Juan Carrasquilla , Lukasz Cincio , Yong Baek Kim

While most work on the quantum simulation of chemistry has focused on computing energy surfaces, a similarly important application requiring subtly different algorithms is the computation of energy derivatives. Almost all molecular…

Simulating molecular systems on quantum processors has the potential to surpass classical methods in computational resource efficiency. The limited qubit connectivity, small processor size, and short coherence times of near-term quantum…

Quantum Physics · Physics 2025-04-08 Abhishek Sadhu , Aritra Sarkar , Akash Kundu

Tensor contraction operations in computational chemistry consume significant fractions of computing time on large-scale computing platforms. The widespread use of tensor contractions between large multi-dimensional tensors in describing…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-07-11 Erdal Mutlu , Ajay Panyala , Nitin Gawande , Abhishek Bagusetty , Jinsung Kim , Karol Kowalski , Nicholas Bauman , Bo Peng , Jiri Brabec , Sriram Krishnamoorthy

Accurate prediction of protein active-site structures remains a central challenge in structural biology, particularly for short and flexible peptide fragments where conventional and simulation-based methods often fail. Here, we present a…

Over the last century, a large number of physical and mathematical developments paired with rapidly advancing technology have allowed the field of quantum chemistry to advance dramatically. However, the lack of computationally efficient…

Quantum Physics · Physics 2011-03-08 James D. Whitfield , Jacob Biamonte , Alán Aspuru-Guzik

We present a comprehensive end-to-end framework for simulating the real-time dynamics of chemical systems on a fault-tolerant quantum computer, incorporating both electronic and nuclear quantum degrees of freedom. An all-particle simulation…

It is widely recognized that quantum computing has profound impacts on multiple fields, including but not limited to cryptography, machine learning, materials science, etc. To run quantum algorithms, it is essential to develop scalable…

Quantum Physics · Physics 2026-04-23 Linghang Kong , Fang Zhang , Jianxin Chen

Accurate and scalable methods for computational quantum chemistry can accelerate research and development in many fields, ranging from drug discovery to advanced material design. Solving the electronic Schrodinger equation is the core…

The study and prediction of chemical reactivity is one of the most important application areas of molecular quantum chemistry. Large-scale, fully error-tolerant quantum computers could provide exact or near-exact solutions to the underlying…

Quantum Physics · Physics 2019-09-12 Michael Kühn , Sebastian Zanker , Peter Deglmann , Michael Marthaler , Horst Weiß

Quantum computers are expected to bring drastic acceleration to several computing tasks against classical computers. Noisy intermediate-scale quantum (NISQ) devices, which have tens to hundreds of noisy physical qubits, are gradually…

Quantum Physics · Physics 2024-08-28 Yutaro Akahoshi , Kazunori Maruyama , Hirotaka Oshima , Shintaro Sato , Keisuke Fujii