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We study the electro-diffusion properties of a domain containing a cusp-shaped structure in three dimensions when one ionic specie is dominant. The mathematical problem consists in solving the steady-state Poisson-Nernst-Planck (PNP)…

Neurons and Cognition · Quantitative Biology 2017-10-09 J. Cartailler , D. Holcman

A model for the current-voltage characteristic of the junction between an Ion-Sensitive-Membrane and an electrolyte solution is derived and compared with numerical simulations of the Poisson-Nernst-Planck model for ion transport. The…

Chemical Physics · Physics 2024-09-18 Leandro Julian Mele , Muhammad Ashraful Alam , Pierpaolo Palestri

In this paper we propose and analyze a finite difference numerical scheme for the Poisson-Nernst-Planck equation (PNP) system. To understand the energy structure of the PNP model, we make use of the Energetic Variational Approach (EnVarA),…

Numerical Analysis · Mathematics 2020-09-18 Chun Liu , Cheng Wang , Steven M. Wise , Xingye Yue , Shenggao Zhou

We report a multiscale modeling study for charged cylindrical nanopores using three modeling levels that include (1) an all-atom explicit-water model studied with molecular dynamics (MD), and reduced models with implicit water containing…

In studies of the brain and the nervous system, extracellular signals - as measured by local field potentials (LFPs) or electroencephalography (EEG) - are of capital importance, as they allow to simultaneously obtain data from multiple…

Neurons and Cognition · Quantitative Biology 2019-06-10 Jurgis Pods

Ion transport through narrow channels is described by the coupled Poisson--Nernst--Planck--Stokes equations (PNPS) on a continuum scale. However, direct numerical simulations in two or three dimensions of boundary value problems for small…

Analysis of PDEs · Mathematics 2026-03-10 Christine Keller , Andreas Münch , Barbara Wagner

This is an early but comprehensive review of the PNP Poisson Nernst Planck theory of ion channels. Extensive reference is made to the earlier literature. The starting place for this theory of open channels is a theory of electrodiffusion…

Biomolecules · Quantitative Biology 2010-09-16 Bob Eisenberg

Species transport models typically combine partial differential equations (PDEs) with relations from hindered transport theory to quantify electromigrative, convective, and diffusive transport through complex nanoporous systems; however,…

Machine Learning · Computer Science 2023-12-06 Danyal Rehman , John H. Lienhard

At mesoscopic scales electrolyte solutions are modeled by the fluctuating generalized Poisson-Nernst-Planck (PNP) equations [J.-P. P\'eraud et al., Phys. Rev. F, 1(7):074103, 2016]. However, at length and time scales larger than the Debye…

Computational Physics · Physics 2019-04-10 Aleksandar Donev , Andrew J. Nonaka , Changho Kim , Alejandro L. Garcia , John B. Bell

We consider a coupled system of Navier-Stokes and Nernst-Planck equations, describing the evolution of the velocity and the concentration fields of dissolved constituents in an electrolyte solution. Motivated by recent applications in the…

Analysis of PDEs · Mathematics 2012-06-12 Dieter Bothe , André Fischer , Jürgen Saal

A model is presented for the solution of electrokinetic phenomena of colloidal suspensions in fluid mixtures. We solve the discrete Boltzmann equation with a BGK collision operator using the lattice Boltzmann method to simulate binary fluid…

Soft Condensed Matter · Physics 2018-05-09 Nicolas Rivas , Stefan Frijters , Ignacio Pagonabarraga , Jens Harting

The transport and distribution of charged particles are crucial in the study of many physical and biological problems. In this paper, we employ an Energy Variational Approach to derive the coupled Poisson-Nernst-Planck-Navier-Stokes system.…

Fluid Dynamics · Physics 2014-10-14 Shixin Xu , Ping Sheng , Chun Liu

Ion transport in biological and synthetic nanochannels is characterized by phenomena such as ion current fluctuations and rectification. Recently, it has been demonstrated that nanofabricated synthetic pores can mimic transport properties…

Classical Physics · Physics 2009-11-13 I. D. Kosińska , I. Goychuk , M. Kostur , G. Schmid , P. Hänggi

We develop a modified Poisson-Nernst-Planck model which includes both the long-range Coulomb and short-range hard-sphere correlations in its free energy functional such that the model can accurately describe the ion transport in complex…

Computational Physics · Physics 2021-05-21 Manman Ma , Zhenli Xu , Liwei Zhang

The Nernst-Planck-Navier-Stokes system models electrodiffusion of ions in a fluid. We prove global existence of solutions in bounded domains in three dimensions with either blocking (no-flux) or uniform selective (special Dirichlet)…

Analysis of PDEs · Mathematics 2020-08-25 Peter Constantin , Mihaela Ignatova , Fizay-Noah Lee

The Nernst-Planck-Stokes (NPS) system models electroconvection of ions in a fluid. We consider the system, for two oppositely charged ionic species, on three dimensional bounded domains with Dirichlet boundary conditions for the ionic…

Analysis of PDEs · Mathematics 2023-01-06 Fizay-Noah Lee

This work is concerned with the stationary Poisson--Nernst--Planck equation with a large parameter which describes a huge number of ions occupying an electrolytic region. Firstly, we focus on the model with a single specie of positive…

Analysis of PDEs · Mathematics 2023-11-20 Jhih-Hong Lyu , Chiun-Chang Lee , Tai-Chia Lin

We present the theory and implementation of a Poisson-Boltzmann implicit solvation model for electrolyte solutions. This model can be combined with arbitrary electronic structure methods that provide an accurate charge density of the…

Computational Physics · Physics 2020-01-08 Christopher J. Stein , John M. Herbert , Martin Head-Gordon

This paper presents an efficient finite element iterative method for solving a nonuniform size-modified Poisson-Nernst-Planck ion channel (SMPNPIC) model, along with a SMPNPIC program package that works for an ion channel protein with a…

Numerical Analysis · Mathematics 2024-05-06 Dexuan Xie

We consider ionic electrodiffusion in fluids, described by the Nernst-Planck-Navier-Stokes system in bounded domains, in two dimensions, with Dirichlet boundary conditions for the Navier-Stokes and Poisson equations, and blocking (vanishing…

Analysis of PDEs · Mathematics 2018-12-26 Peter Constantin , Mihaela Ignatova