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Diffusion models have emerged as powerful tools for 3D medical image generation, yet bridging the gap between standard training objectives and clinical relevance remains a challenge. This paper presents a method to enhance 3D diffusion…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yueying Tian , Xudong Han , Meng Zhou , Rodrigo Aviles-Espinosa , Rupert Young , Philip Birch

Diffusion alignment adapts pretrained diffusion models to sample from reward-tilted distributions along the denoising trajectory. This process naturally admits a Sequential Monte Carlo (SMC) interpretation, where the denoising model acts as…

Machine Learning · Computer Science 2026-02-13 Zijing Ou , Jacob Si , Junyi Zhu , Ondrej Bohdal , Mete Ozay , Taha Ceritli , Yingzhen Li

In text-to-image generation tasks, the advancements of diffusion models have facilitated the fidelity of generated results. However, these models encounter challenges when processing text prompts containing multiple entities and attributes.…

Computation and Language · Computer Science 2024-04-23 Yihang Wu , Xiao Cao , Kaixin Li , Zitan Chen , Haonan Wang , Lei Meng , Zhiyong Huang

Reinforcement learning (RL) has emerged as a powerful tool for aligning diffusion models with human preferences, typically by optimizing a single reward function under a KL regularization constraint. In practice, however, human preferences…

Machine Learning · Computer Science 2026-04-17 Qi Zhang , Dawei Wang , Shaofeng Zou

Recent studies have demonstrated significant progress in aligning text-to-image diffusion models with human preference via Reinforcement Learning from Human Feedback. However, while existing methods achieve high scores on automated reward…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Chubin Chen , Sujie Hu , Jiashu Zhu , Meiqi Wu , Jintao Chen , Yanxun Li , Nisha Huang , Chengyu Fang , Jiahong Wu , Xiangxiang Chu , Xiu Li

Diffusion models excel at capturing the natural design spaces of images, molecules, DNA, RNA, and protein sequences. However, rather than merely generating designs that are natural, we often aim to optimize downstream reward functions while…

Inference-time control of diffusion models aims to steer model outputs to satisfy new constraints without retraining. Previous approaches have mostly relied on heuristic guidance or have been coupled with Sequential Monte Carlo (SMC) for…

Reinforcement learning from human feedback (RLHF), which aligns a diffusion model with input prompt, has become a crucial step in building reliable generative AI models. Most works in this area use a discrete-time formulation, which is…

Machine Learning · Computer Science 2025-08-25 Hanyang Zhao , Haoxian Chen , Ji Zhang , David D. Yao , Wenpin Tang

In image processing, solving inverse problems is the task of finding plausible reconstructions of an image that was corrupted by some (usually known) degradation operator. Commonly, this process is done using a generative image model that…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Idan Achituve , Hai Victor Habi , Amir Rosenfeld , Arnon Netzer , Idit Diamant , Ethan Fetaya

Diffusion models have achieved state-of-the-art performance across multiple domains, with recent advancements extending their applicability to discrete data. However, aligning discrete diffusion models with task-specific preferences remains…

Machine Learning · Computer Science 2025-04-10 Umberto Borso , Davide Paglieri , Jude Wells , Tim Rocktäschel

Diffusion and flow-matching models scale because pretraining is supervised regression: a clean sample is noised analytically, and a model regresses against a closed-form target. RL post-training aligns the model with a reward. In image…

Machine Learning · Computer Science 2026-05-19 Andreas Bergmeister , Stefanie Jegelka , Nikolas Nüsken , Carles Domingo-Enrich , Jakiw Pidstrigach

Aligning Diffusion models has achieved remarkable breakthroughs in generating high-quality, human preference-aligned images. Existing techniques, such as supervised fine-tuning (SFT) and DPO-style preference optimization, have become…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Zening Sun , Zhengpeng Xie , Lichen Bai , Shitong Shao , Shuo Yang , Zeke Xie

Diffusion models exhibit excellent sample quality, but existing guidance methods often require additional model training or are limited to specific tasks. We revisit guidance in diffusion models from the perspective of variational inference…

Machine Learning · Computer Science 2025-05-27 Kushagra Pandey , Farrin Marouf Sofian , Felix Draxler , Theofanis Karaletsos , Stephan Mandt

Recent advancements in diffusion and flow-matching models have demonstrated remarkable capabilities in high-fidelity image synthesis. A prominent line of research involves reward-guided guidance, which steers the generation process during…

Computer Vision and Pattern Recognition · Computer Science 2026-05-01 Jinho Chang , Jaemin Kim , Jong Chul Ye

Diffusion models generate samples by estimating the score function of the target distribution at various noise levels. The model is trained using samples drawn from the target distribution by progressively adding noise. Previous sample…

Machine Learning · Computer Science 2025-10-28 Syamantak Kumar , Dheeraj Nagaraj , Purnamrita Sarkar

Diffusion models have demonstrated their capabilities in modeling trajectories of multi-tasks. However, existing multi-task planners or policies typically rely on task-specific demonstrations via multi-task imitation, or require…

Machine Learning · Computer Science 2025-07-15 Chenyou Fan , Chenjia Bai , Zhao Shan , Haoran He , Yang Zhang , Zhen Wang

Diffusion models are an important tool for generative modelling, serving as effective priors in applications such as imaging and protein design. A key challenge in applying diffusion models for downstream tasks is efficiently sampling from…

Machine Learning · Computer Science 2026-02-12 Alexander Denker , Shreyas Padhy , Francisco Vargas , Johannes Hertrich

This study presents a generative optimization framework that builds on a fine-tuned diffusion model and reward-directed sampling to generate high-performance engineering designs. The framework adopts a parametric representation of the…

Machine Learning · Computer Science 2025-08-05 Hadi Keramati , Patrick Kirchen , Mohammed Hannan , Rajeev K. Jaiman

Diffusion models have emerged as a powerful framework in generative modeling, typically relying on optimizing neural networks to estimate the score function via forward SDE simulations. In this work, we propose an alternative method that is…

Numerical Analysis · Mathematics 2025-06-17 Yuehaw Khoo , Mathias Oster , Yifan Peng

We explore the methodology and theory of reward-directed generation via conditional diffusion models. Directed generation aims to generate samples with desired properties as measured by a reward function, which has broad applications in…

Machine Learning · Computer Science 2023-07-17 Hui Yuan , Kaixuan Huang , Chengzhuo Ni , Minshuo Chen , Mengdi Wang
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