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Cell instance segmentation is a fundamental task in digital pathology with broad clinical applications. Recently, vision foundation models, which are predominantly based on Vision Transformers (ViTs), have achieved remarkable success in…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Yang Yang , Xijie Xu , Yixun Zhou , Jie Zheng

Nuclei detection and segmentation in hematoxylin and eosin-stained (H&E) tissue images are important clinical tasks and crucial for a wide range of applications. However, it is a challenging task due to nuclei variances in staining and…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Fabian Hörst , Moritz Rempe , Lukas Heine , Constantin Seibold , Julius Keyl , Giulia Baldini , Selma Ugurel , Jens Siveke , Barbara Grünwald , Jan Egger , Jens Kleesiek

Nucleus segmentation is an important analysis task in digital pathology. However, methods for automatic segmentation often struggle with new data from a different distribution, requiring users to manually annotate nuclei and retrain…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Titus Griebel , Anwai Archit , Constantin Pape

Cell nuclei instance segmentation is a crucial task in digital kidney pathology. Traditional automatic segmentation methods often lack generalizability when applied to unseen datasets. Recently, the success of foundation models (FMs) has…

Foundation models have revolutionized the paradigm of digital pathology, as they leverage general-purpose features to emulate real-world pathological practices, enabling the quantitative analysis of critical histological patterns and the…

Cell microscopy data are abundant; however, corresponding segmentation annotations remain scarce. Moreover, variations in cell types, imaging devices, and staining techniques introduce significant domain gaps between datasets. As a result,…

Machine Learning · Computer Science 2026-01-27 Rüveyda Yilmaz , Zhu Chen , Yuli Wu , Johannes Stegmaier

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

Nuclei segmentation is a crucial task for whole slide image analysis in digital pathology. Generally, the segmentation performance of fully-supervised learning heavily depends on the amount and quality of the annotated data. However, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Yi Lin , Zhiyong Qu , Hao Chen , Zhongke Gao , Yuexiang Li , Lili Xia , Kai Ma , Yefeng Zheng , Kwang-Ting Cheng

Deep learning has been widely used in medical image segmentation and other aspects. However, the performance of existing medical image segmentation models has been limited by the challenge of obtaining sufficient high-quality labeled data…

Computer Vision and Pattern Recognition · Computer Science 2023-06-28 Zihan Li , Yunxiang Li , Qingde Li , Puyang Wang , Dazhou Guo , Le Lu , Dakai Jin , You Zhang , Qingqi Hong

Accurate nuclei segmentation in microscopy whole slide images (WSIs) remains challenging due to variability in staining, imaging conditions, and tissue morphology. We propose CellGenNet, a knowledge distillation framework for robust…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Srijan Ray , Bikesh K. Nirala , Jason T. Yustein , Sundaresh Ram

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly

Plant diseases significantly threaten global food security by reducing crop yields and undermining agricultural sustainability. AI-driven automated classification has emerged as a promising solution, with deep learning models demonstrating…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Moshiur Rahman Tonmoy , Md. Mithun Hossain , Nilanjan Dey , M. F. Mridha

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

Unets have become the standard method for semantic segmentation of medical images, along with fully convolutional networks (FCN). Unet++ was introduced as a variant of Unet, in order to solve some of the problems facing Unet and FCNs.…

Computer Vision and Pattern Recognition · Computer Science 2022-06-13 Samayan Bhattacharya , Sk Shahnawaz , Avigyan Bhattacharya

Accurate semantic segmentation for histopathology image is crucial for quantitative tissue analysis and downstream clinical modeling. Recent segmentation foundation models have improved generalization through large-scale pretraining, yet…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Peixian Liang , Songhao Li , Shunsuke Koga , Yutong Li , Zahra Alipour , Yucheng Tang , Daguang Xu , Zhi Huang

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

Histopathology, the microscopic study of diseased tissue, is increasingly digitized, enabling improved visualization and streamlined workflows. An important task in histopathology is the segmentation of cells and glands, essential for…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Philipp Endres , Valentin Koch , Julia A. Schnabel , Carsten Marr

Accurate cell segmentation in pathology images typically requires dense pixel-wise annotations, which are costly and time-consuming to obtain. This challenge is especially important for emerging biological imaging modalities and multiplexed…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Gunjan Shrivastava , Saad Nadeem

The deployment of advanced deep learning models for medical image segmentation is often constrained by the requirement for extensively annotated datasets. Weakly-supervised learning, which allows less precise labels, has become a promising…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Thien B. Nguyen-Tat , Hoang-An Vo , Phuoc-Sang Dang

Developing computational pathology models is essential for reducing manual tissue typing from whole slide images, transferring knowledge from the source domain to an unlabeled, shifted target domain, and identifying unseen categories. We…

Computer Vision and Pattern Recognition · Computer Science 2024-01-26 Guillaume Vray , Devavrat Tomar , Jean-Philippe Thiran , Behzad Bozorgtabar
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