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Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are often continuous measurements.…

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a gene editing technology that has revolutionized the fields of biology and medicine. However, one of the challenges of using CRISPR is predicting the on-target efficacy…

Machine Learning · Computer Science 2024-03-06 Mohammad Rostami , Amin Ghariyazi , Hamed Dashti , Mohammad Hossein Rohban , Hamid R. Rabiee

The performance of deep learning (DL) methods for the analysis of cine cardiovascular magnetic resonance (CMR) is typically assessed in terms of accuracy, overlooking precision. In this work, uncertainty estimation techniques, namely deep…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Dewmini Hasara Wickremasinghe , Michelle Gibogwe , Andrew Bell , Esther Puyol-Antón , Muhummad Sohaib Nazir , Reza Razavi , Bruno Paun , Paul Aljabar , Andrew P. King

Accurate uncertainty estimation is a critical need for the medical imaging community. A variety of methods have been proposed, all direct extensions of classification uncertainty estimations techniques. The independent pixel-wise…

Image and Video Processing · Electrical Eng. & Systems 2022-06-16 Thierry Judge , Olivier Bernard , Mihaela Porumb , Agis Chartsias , Arian Beqiri , Pierre-Marc Jodoin

A comprehensive study on machine and deep learning techniques for classification of normal and abnormal cervical cells by using pap smear images from Herlev dataset results are presented. This dataset includes 917 images and 7 different…

Image and Video Processing · Electrical Eng. & Systems 2020-09-15 Abdurrahim Yilmaz , Ali Anil Demircali , Sena Kocaman , Huseyin Uvet

Efficacy testing is a cornerstone of clinical trials, ensuring that medical interventions achieve their intended therapeutic effects. Over the decades, a wide range of statistical methodologies have been developed to address the…

Other Statistics · Statistics 2026-04-13 Dhrubajyoti Ghosh , Samhita Pal

To address the issues of limited samples, time-consuming feature design, and low accuracy in detection and classification of breast cancer pathological images, a breast cancer image classification model algorithm combining deep learning and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-12 Weimin Wang , Yufeng Li , Xu Yan , Mingxuan Xiao , Min Gao

Research increasingly relies on computational methods to analyze experimental data and predict molecular properties. Current approaches often require researchers to use a variety of tools for statistical analysis and machine learning,…

Quantitative Methods · Quantitative Biology 2025-12-01 Luke Rimmo Lego , Samantha Gauthier , Denver Jn. Baptiste

Photoplethysmographic (PPG) signals offer diagnostic potential beyond heart rate analysis or blood oxygen level monitoring. In the recent past, research focused extensively on non-invasive PPG-based approaches to blood pressure (BP)…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Fabian Schrumpf , Paul Rudi Serdack , Mirco Fuchs

The estimated accuracy of a classifier is a random quantity with variability. A common practice in supervised machine learning, is thus to test if the estimated accuracy is significantly better than chance level. This method of signal…

Methodology · Statistics 2020-01-28 Jonathan D. Rosenblatt , Yuval Benjamini , Roee Gilron , Roy Mukamel , Jelle J. Goeman

Brain stroke is a leading cause of mortality and long-term disability worldwide, underscoring the need for precise and rapid prediction techniques. Computed Tomography (CT) scan is considered one of the most effective methods for diagnosing…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Md. Sabbir Hossen , Eshat Ahmed Shuvo , Shibbir Ahmed Arif , Pabon Shaha , Anichur Rahman , Md. Saiduzzaman , Fahmid Al Farid , Hezerul Abdul Karim , Abu Saleh Musa Miah

Feature or variable selection is a problem inherent to large data sets. While many methods have been proposed to deal with this problem, some can scale poorly with the number of predictors in a data set. Screening methods scale linearly…

Methodology · Statistics 2023-01-09 Naveed Merchant , Jeffrey D. Hart

The breakthrough in Deep Learning neural networks has transformed the use of AI and machine learning technologies for the analysis of very large experimental datasets. These datasets are typically generated by large-scale experimental…

Machine Learning · Computer Science 2021-10-26 Jeyan Thiyagalingam , Mallikarjun Shankar , Geoffrey Fox , Tony Hey

Several studies point out different causes of performance degradation in supervised machine learning. Problems such as class imbalance, overlapping, small-disjuncts, noisy labels, and sparseness limit accuracy in classification algorithms.…

Machine Learning · Computer Science 2020-04-17 Gustavo A. Valencia-Zapata , Carolina Gonzalez-Canas , Michael G. Zentner , Okan Ersoy , Gerhard Klimeck

Classification of proteins based on their structure provides a valuable resource for studying protein structure, function and evolutionary relationships. With the rapidly increasing number of known protein structures, manual and…

Computational Engineering, Finance, and Science · Computer Science 2009-07-14 Oktie Hassanzadeh

The Gleason grading system using histological images is the most powerful diagnostic and prognostic predictor of prostate cancer. The current standard inspection is evaluating Gleason H&E-stained histopathology images by pathologists.…

Image and Video Processing · Electrical Eng. & Systems 2020-12-10 Haotian Xie , Yong Zhang , Jun Wang , Jingjing Zhang , Yifan Ma , Zhaogang Yang

Machine learning-based decision support systems are increasingly deployed in clinical settings, where probabilistic scoring functions are used to inform and prioritize patient management decisions. However, widely used scoring rules, such…

Machine Learning · Computer Science 2025-07-01 Gerardo A. Flores , Alyssa H. Smith , Julia A. Fukuyama , Ashia C. Wilson

We apply machine learning techniques in an attempt to predict and classify stellar properties from noisy and sparse time series data. We preprocessed over 94 GB of Kepler light curves from MAST to classify according to ten distinct physical…

Instrumentation and Methods for Astrophysics · Physics 2018-06-27 Trisha Hinners , Kevin Tat , Rachel Thorp

Since the advent of CRISPR-Cas9, a groundbreaking gene-editing technology that enables precise genomic modifications via a short RNA guide sequence, there has been a marked increase in the accessibility and application of this technology…

Quantitative Methods · Quantitative Biology 2024-09-11 Condy Bao , Fuxiao Liu

Recent advances in probabilistic modelling have led to a large number of simulation-based inference algorithms which do not require numerical evaluation of likelihoods. However, a public benchmark with appropriate performance metrics for…

Machine Learning · Statistics 2021-04-12 Jan-Matthis Lueckmann , Jan Boelts , David S. Greenberg , Pedro J. Gonçalves , Jakob H. Macke