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We consider a system of $N$ interacting particles, governed by transport and diffusion, that converges in a mean-field limit to the solution of a McKean-Vlasov equation. From the observation of a trajectory of the system over a fixed time…

Statistics Theory · Mathematics 2021-03-16 Laetitia Della Maestra , Marc Hoffmann

The use of high-frequency currents in neurostimulation has received increased attention in recent years due to its varied effects on tissues and cells. Nonlinear differential equations are commonly used as models for Neurons, and averaging…

Analysis of PDEs · Mathematics 2025-12-29 Eduardo Cerpa , Matías Courdurier , Esteban Hernández , Leonel E. Medina , Esteban Paduro

The stochastic FitzHugh-Nagumo (FHN) model is a two-dimensional nonlinear stochastic differential equation with additive degenerate noise, whose first component, the only one observed, describes the membrane voltage evolution of a single…

Computation · Statistics 2024-10-08 Adeline Samson , Massimiliano Tamborrino , Irene Tubikanec

The paper addresses the problem of parameter estimation (or identification) in dynamical networks composed of an arbitrary number of FitzHugh-Nagumo neuron models with diffusive couplings between each other. It is assumed that only the…

Systems and Control · Electrical Eng. & Systems 2025-02-25 Aleksandra Rybalko , Alexander Fradkov

We consider a spatially extended mesoscopic FitzHugh-Nagumo model with strong local interactions and prove that its asymptotic limit converges towards the classical nonlocal reaction-diffusion FitzHugh-Nagumo system. As the local…

Analysis of PDEs · Mathematics 2022-08-31 Alain Blaustein , Francis Filbet

We consider the existence and first order conditions of optimality for a stochastic optimal control problem inspired by the celebrated FitzHugh-Nagumo model, with nonlinear diffusion term, perturbed by a linear multiplicative Brownian-type…

Optimization and Control · Mathematics 2019-12-03 Francesco Cordoni , Luca Di Persio

This paper is devoted to the numerical approximation of the spatially-extended FitzHugh-Nagumo transport equation with strong local interactions based on a particle method. In this regime, the time step can be subject to stability…

Numerical Analysis · Mathematics 2020-09-30 Joachim Crevat , Francis Filbet

We design and study splitting integrators for the temporal discretization of the stochastic FitzHugh--Nagumo system. This system is a model for signal propagation in nerve cells where the voltage variable is solution of a one-dimensional…

Numerical Analysis · Mathematics 2022-07-22 Charles-Edouard Bréhier , David Cohen , Giuseppe Giordano

Neurons are the central biological objects in understanding how the brain works. The famous Hodgkin-Huxley model, which describes how action potentials of a neuron are initiated and propagated, consists of four coupled nonlinear…

Neurons and Cognition · Quantitative Biology 2010-02-01 William Hanan , Dhagash Mehta , Guillaume Moroz , Sepanda Pouryahya

We derive the mean-field equations arising as the limit of a network of interacting spiking neurons, as the number of neurons goes to infinity. The neurons belong to a fixed number of populations and are represented either by the…

Neurons and Cognition · Quantitative Biology 2016-11-25 Javier Baladron , Diego Fasoli , Olivier Faugeras , Jonathan Touboul

The FitzHugh-Nagumo (FHN) model, from computational neuroscience, has attracted attention in nonlinear dynamics studies as it describes the behavior of excitable systems and exhibits interesting bifurcation properties. The accurate…

Pattern Formation and Solitons · Physics 2021-02-09 Shady E. Ahmed , Omer San , Sivaramakrishnan Lakshmivarahan

We consider the long-time behavior of a population of mean-field oscillators modeling the activity of interacting excitable neurons in large population. Each neuron is represented by its voltage and recovery variables, which are solution to…

Probability · Mathematics 2019-06-24 Eric Luçon , Christophe Poquet

In this article, we are interested in the behavior of a fully connected network of $N$ neurons, where $N$ tends to infinity. We assume that the neurons follow the stochastic FitzHugh-Nagumo model, whose specificity is the non-linearity with…

Probability · Mathematics 2024-02-14 Laetitia Colombani , Pierre Le Bris

We consider a spatially extended mean-field model of a FitzHugh-Nagumo neural network, with a rescaled interaction kernel. Our main purpose is to prove that its asymptotic limit in the regime of strong local interactions converges toward a…

Analysis of PDEs · Mathematics 2020-03-17 Joachim Crevat

We investigate the dynamics of a limit of interacting FitzHugh-Nagumo neurons in the regime of large interaction coefficients. We consider the dynamics described by a mean-field model given by a nonlinear evolution partial differential…

Analysis of PDEs · Mathematics 2018-12-03 Cristobal Quiñinao , Jonathan D. Touboul

This article introduces a novel approach to the mean-field limit of stochastic systems of interacting particles, leading to the first ever derivation of the mean-field limit to the Vlasov-Poisson-Fokker-Planck system for plasmas in…

Analysis of PDEs · Mathematics 2025-04-02 Didier Bresch , Pierre-Emmanuel Jabin , Juan Soler

The FitzHugh-Nagumo equation, originally conceived in neuroscience during the 1960s, became a key model providing a simplified view of excitable neuron cell behavior. Its applicability, however, extends beyond neuroscience into fields like…

Pattern Formation and Solitons · Physics 2025-01-08 Daniel Cebrián-Lacasa , Pedro Parra-Rivas , Daniel Ruiz-Reynés , Lendert Gelens

The statistical problem of parameter estimation in partially observed hypoelliptic diffusion processes is naturally occurring in many applications. However, due to the noise structure, where the noise components of the different coordinates…

Methodology · Statistics 2018-11-13 Susanne Ditlevsen , Adeline Samson

Being an example for a relaxation oscillator, the FitzHugh-Nagumo model has been widely employed for describing the generation of action potentials. In this paper, we begin with a biological interpretation of what the subsequent…

Numerical Analysis · Mathematics 2025-01-31 Burcu Gürbüz , Aytül Gökçe , Mahmut Modanlı

We study the stochastic FitzHugh-Nagumo equations, modelling the dynamics of neuronal action potentials, in parameter regimes characterised by mixed-mode oscillations. The interspike time interval is related to the random number of…

Probability · Mathematics 2012-07-10 Nils Berglund , Damien Landon
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