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Generation of molecules with desired chemical and biological properties such as high drug-likeness, high binding affinity to target proteins, is critical for drug discovery. In this paper, we propose a probabilistic generative model to…

Biomolecules · Quantitative Biology 2023-07-12 Deqian Kong , Bo Pang , Tian Han , Ying Nian Wu

Random graph models are frequently used as a controllable and versatile data source for experimental campaigns in various research fields. Generating such data-sets at scale is a non-trivial task as it requires design decisions typically…

Data Structures and Algorithms · Computer Science 2020-03-03 Manuel Penschuck , Ulrik Brandes , Michael Hamann , Sebastian Lamm , Ulrich Meyer , Ilya Safro , Peter Sanders , Christian Schulz

Generating molecules with desired biological activities has attracted growing attention in drug discovery. Previous molecular generation models are designed as chemocentric methods that hardly consider the drug-target interaction, limiting…

Machine Learning · Computer Science 2022-10-24 Cheng Tan , Zhangyang Gao , Stan Z. Li

Large-scale diffusion models have achieved remarkable success in generating high-quality images from textual descriptions, gaining popularity across various applications. However, the generation of layered content, such as transparent…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Yusuf Dalva , Yijun Li , Qing Liu , Nanxuan Zhao , Jianming Zhang , Zhe Lin , Pinar Yanardag

Deep Generative Models are frequently used to learn continuous representations of complex data distributions using a finite number of samples. For any generative model, including pre-trained foundation models with Diffusion or Transformer…

Recently, diffusion models have achieved great success in image synthesis. However, when it comes to the layout-to-image generation where an image often has a complex scene of multiple objects, how to make strong control over both the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Guangcong Zheng , Xianpan Zhou , Xuewei Li , Zhongang Qi , Ying Shan , Xi Li

Recent advances in deep learning have accelerated its use in various applications, such as cellular image analysis and molecular discovery. In molecular discovery, a generative adversarial network (GAN), which comprises a discriminator to…

Machine Learning · Computer Science 2023-04-13 Daniel Manu , Jingjing Yao , Wuji Liu , Xiang Sun

Edge intelligence has arisen as a promising computing paradigm for supporting miscellaneous smart applications that rely on machine learning techniques. While the community has extensively investigated multi-tier edge deployment for…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-11-01 Liekang Zeng , Chongyu Yang , Peng Huang , Zhi Zhou , Shuai Yu , Xu Chen

Deep generative models have made rapid progress in image, text, audio, and video generation, and are increasingly being applied to structured records. For tabular data, however, generative modeling remains difficult: a dataset may contain…

Machine Learning · Computer Science 2026-05-25 Zhong Li , Qi Huang , Lincen Yang , Jiayang Shi , Zhao Yang , Niki van Stein , Thomas Bäck , Matthijs van Leeuwen

Deep generative models have garnered significant attention in low-level vision tasks due to their generative capabilities. Among them, diffusion model-based solutions, characterized by a forward diffusion process and a reverse denoising…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Chunming He , Yuqi Shen , Chengyu Fang , Fengyang Xiao , Longxiang Tang , Yulun Zhang , Wangmeng Zuo , Zhenhua Guo , Xiu Li

Stable diffusion models have ushered in a new era of advancements in image generation, currently reigning as the state-of-the-art approach, exhibiting unparalleled performance. The process of diffusion, accompanied by denoising through…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Andras Horvath

Diffusion and flow-based generative models have achieved remarkable success in domains such as image synthesis, video generation, and natural language modeling. In this work, we extend these advances to weight space learning by leveraging…

Machine Learning · Computer Science 2025-10-17 Daniel Saragih , Deyu Cao , Tejas Balaji

Photonic crystals enable fine control over light propagation at the nanoscale, and thus play a central role in the development of photonic and quantum technologies. Photonic band diagrams (BDs) are a key tool to investigate light…

The advent of deep learning has introduced efficient approaches for de novo protein sequence design, significantly improving success rates and reducing development costs compared to computational or experimental methods. However, existing…

Artificial Intelligence · Computer Science 2024-07-11 Yutong Hu , Yang Tan , Andi Han , Lirong Zheng , Liang Hong , Bingxin Zhou

Molecular graphs generally contain subgraphs (known as groups) that are identifiable and significant in composition, functionality, geometry, etc. Flat latent representations (node embeddings or graph embeddings) fail to represent, and…

Machine Learning · Computer Science 2019-04-05 Daniel T. Chang

Scaling deep learning models has been at the heart of recent revolutions in language modelling and image generation. Practitioners have observed a strong relationship between model size, dataset size, and performance. However,…

Graph Neural Networks (GNNs) have been widely employed for feature representation learning in molecular graphs. Therefore, it is crucial to enhance the expressiveness of feature representation to ensure the effectiveness of GNNs. However, a…

Machine Learning · Computer Science 2024-09-16 Chengyu Yao , Hong Huang , Hang Gao , Fengge Wu , Haiming Chen , Junsuo Zhao

A molecule's geometry, also known as conformation, is one of a molecule's most important properties, determining the reactions it participates in, the bonds it forms, and the interactions it has with other molecules. Conventional…

Machine Learning · Computer Science 2020-01-01 Elman Mansimov , Omar Mahmood , Seokho Kang , Kyunghyun Cho

Graph generation is a critical task across scientific domains. Existing methods fall broadly into two categories: autoregressive models, which iteratively expand graphs, and one-shot models, such as diffusion, which generate the full graph…

Machine Learning · Computer Science 2025-12-02 Nagham Osman , Keyue Jiang , Davide Buffelli , Xiaowen Dong , Laura Toni

Diffusion-based generative graph models have been proven effective in generating high-quality small graphs. However, they need to be more scalable for generating large graphs containing thousands of nodes desiring graph statistics. In this…

Machine Learning · Computer Science 2023-06-01 Xiaohui Chen , Jiaxing He , Xu Han , Li-Ping Liu