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Deep learning-based medical image segmentation faces significant challenges arising from limited labeled data and domain shifts. While prior approaches have primarily addressed these issues independently, their simultaneous occurrence is…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Zanting Ye , Ke Wang , Wenbing Lv , Qianjin Feng , Lijun Lu

Domain generalization remains a critical challenge in medical imaging, where models trained on single sources often fail under real-world distribution shifts. We propose KG-DG, a neuro-symbolic framework for diabetic retinopathy (DR)…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Midhat Urooj , Ayan Banerjee , Farhat Shaikh , Kuntal Thakur , Sandeep Gupta

Retinal vessel segmentation plays a key role in computer-aided screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Recently, deep learning-based retinal vessel segmentation algorithms have achieved…

Image and Video Processing · Electrical Eng. & Systems 2021-08-05 Wei Feng , Lie Ju , Lin Wang , Kaimin Song , Xin Wang , Xin Zhao , Qingyi Tao , Zongyuan Ge

Retinal vessel segmentation serves as a critical prerequisite for automated diagnosis of retinal pathologies. While recent advances in Convolutional Neural Networks (CNNs) have demonstrated promising performance in this task, significant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Zhanqiang Guo , Jianjiang Feng , Jie Zhou

To segment medical images with distribution shifts, domain generalization (DG) has emerged as a promising setting to train models on source domains that can generalize to unseen target domains. Existing DG methods are mainly based on CNN or…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Zihan Cheng , Jintao Guo , Jian Zhang , Lei Qi , Luping Zhou , Yinghuan Shi , Yang Gao

Medical image segmentation is critical for clinical diagnosis, treatment planning, and monitoring, yet segmentation models often struggle with uncertainties stemming from occlusions, ambiguous boundaries, and variations in imaging devices.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-05 Xiao Ma , Yuhui Tao , Zetian Zhang , Yuhan Zhang , Xi Wang , Sheng Zhang , Zexuan Ji , Yizhe Zhang , Qiang Chen , Guang Yang

Retinal vessel segmentation plays an imaportant role in the field of retinal image analysis because changes in retinal vascular structure can aid in the diagnosis of diseases such as hypertension and diabetes. In recent research, numerous…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Changlu Guo , Márton Szemenyei , Yugen Yi , Ying Xue , Wei Zhou , Yangyuan Li

Purpose: Applying pre-trained medical deep learning segmentation models on out-of-domain images often yields predictions of insufficient quality. In this study, we propose to use a powerful generalizing descriptor along with augmentation to…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Christian Weihsbach , Christian N. Kruse , Alexander Bigalke , Mattias P. Heinrich

Diabetic retinopathy (DR), a serious ocular complication of diabetes, is one of the primary causes of vision loss among retinal vascular diseases. Deep learning methods have been extensively applied in the grading of diabetic retinopathy…

Image and Video Processing · Electrical Eng. & Systems 2025-04-29 Yunxuan Wang , Ray Yin , Yumei Tan , Hao Chen , Haiying Xia

Various deep learning models have been developed to segment anatomical structures from medical images, but they typically have poor performance when tested on another target domain with different data distribution. Recently, unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2022-01-21 Linkai Peng , Li Lin , Pujin Cheng , Ziqi Huang , Xiaoying Tang

Accurate medical image segmentation is essential for effective diagnosis and treatment planning but is often challenged by domain shifts caused by variations in imaging devices, acquisition conditions, and patient-specific attributes.…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Jie Bao , Zhixin Zhou , Wen Jung Li , Rui Luo

Retinal imaging is fast, non-invasive, and widely available, offering quantifiable structural and vascular signals for ophthalmic and systemic health assessment. This accessibility creates an opportunity to study how quantitative retinal…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Zhonghua Wang , Lie Ju , Sijia Li , Wei Feng , Sijin Zhou , Ming Hu , Jianhao Xiong , Xiaoying Tang , Yifan Peng , Mingquan Lin , Yaodong Ding , Yong Zeng , Wenbin Wei , Li Dong , Zongyuan Ge

Robustness and generalizability in medical image segmentation are often hindered by scarcity and limited diversity of training data, which stands in contrast to the variability encountered during inference. While conventional strategies --…

Computer Vision and Pattern Recognition · Computer Science 2024-12-18 Yimu Pan , Sitao Zhang , Alison D. Gernand , Jeffery A. Goldstein , James Z. Wang

Accurate retinal vessel segmentation is a critical prerequisite for quantitative analysis of retinal images and computer-aided diagnosis of vascular diseases such as diabetic retinopathy. However, the elongated morphology, wide scale…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Ruiqi Song , Lei Liu , Ya-Nan Zhang , Chao Wang , Xiaoning Li , Nan Mu

Vessel segmentation of retinal images is a key diagnostic capability in ophthalmology. This problem faces several challenges including low contrast, variable vessel size and thickness, and presence of interfering pathology such as…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Venkateswararao Cherukuri , Vijay Kumar BG , Raja Bala , Vishal Monga

Single-source domain generalization (SDG) aims to learn a model from a single source domain that can generalize well on unseen target domains. This is an important task in computer vision, particularly relevant to medical imaging where…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Boqi Chen , Yuanzhi Zhu , Yunke Ao , Sebastiano Caprara , Reto Sutter , Gunnar Rätsch , Ender Konukoglu , Anna Susmelj

Medical image segmentation is an important task for computer aided diagnosis. Pixelwise manual annotations of large datasets require high expertise and is time consuming. Conventional data augmentations have limited benefit by not fully…

Image and Video Processing · Electrical Eng. & Systems 2020-04-28 Dwarikanath Mahapatra , Behzad Bozorgtabar , Jean-Philippe Thiran , Ling Shao

Unsupervised domain adaptation has been proposed recently to tackle the so-called domain shift between training data and test data with different distributions. However, most of them only focus on single-target domain adaptation and cannot…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Linkai Peng , Li Lin , Pujin Cheng , Huaqing He , Xiaoying Tang

Generalization in medical segmentation models is challenging due to limited annotated datasets and imaging variability. To address this, we propose Retinal Layout-Aware Diffusion (RLAD), a novel diffusion-based framework for generating…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Jonathan Fhima , Jan Van Eijgen , Lennert Beeckmans , Thomas Jacobs , Moti Freiman , Luis Filipe Nakayama , Ingeborg Stalmans , Chaim Baskin , Joachim A. Behar

Retinal vessel segmentation is critical for diagnosing ocular conditions, yet current deep learning methods are limited by modality-specific challenges and significant distribution shifts across imaging devices, resolutions, and anatomical…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Zixuan Liu , Aaron Honjaya , Yuekai Xu , Yi Zhang , Hefu Pan , Xin Wang , Linda G Shapiro , Sheng Wang , Ruikang K Wang