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This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Mohammad Iqbal Nouyed , Mary-Anne Hartley , Gianfranco Doretto , Donald A. Adjeroh

Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles…

Computer Vision and Pattern Recognition · Computer Science 2018-05-11 Talha Qaiser , Yee-Wah Tsang , Daiki Taniyama , Naoya Sakamoto , Kazuaki Nakane , David Epstein , Nasir Rajpoot

Melanoma is an aggressive form of skin cancer with rapid progression and high metastatic potential. Accurate characterisation of tissue morphology in melanoma is crucial for prognosis and treatment planning. However, manual segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2025-07-21 Jiaqi Lv , Yijie Zhu , Carmen Guadalupe Colin Tenorio , Brinder Singh Chohan , Mark Eastwood , Shan E Ahmed Raza

Masked Autoencoders (MAEs) have been shown to be effective in pre-training Vision Transformers (ViTs) for natural and medical image analysis problems. By reconstructing missing pixel/voxel information in visible patches, a ViT encoder can…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Pengfei Gu , Huimin Li , Yejia Zhang , Chaoli Wang , Danny Z. Chen

We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-29 Eric Cosatto , Kyle Gerard , Hans-Peter Graf , Maki Ogura , Tomoharu Kiyuna , Kanako C. Hatanaka , Yoshihiro Matsuno , Yutaka Hatanaka

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Mammography is crucial for breast cancer surveillance and early diagnosis. However, analyzing mammography images is a demanding task for radiologists, who often review hundreds of mammograms daily, leading to overdiagnosis and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Kun Zhao , Jakub Prokop , Javier Montalt Tordera , Sadegh Mohammadi

The diagnosis and segmentation of tumors using any medical diagnostic tool can be challenging due to the varying nature of this pathology. Magnetic Reso- nance Imaging (MRI) is an established diagnostic tool for various diseases and…

Computer Vision and Pattern Recognition · Computer Science 2017-11-01 Tanvi Gupta , Pranay Manocha , Tapan K. Gandhi , RK Gupta , BK Panigrahi

The segmentation of histopathological whole slide images into tumourous and non-tumourous types of tissue is a challenging task that requires the consideration of both local and global spatial contexts to classify tumourous regions…

Surgical scene segmentation is a fundamental task for robotic-assisted laparoscopic surgery understanding. It often contains various anatomical structures and surgical instruments, where similar local textures and fine-grained structures…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Cheng Yuan , Yutong Ban

Existing promptable segmentation methods in the medical imaging field primarily consider either textual or visual prompts to segment relevant objects, yet they often fall short when addressing anomalies in medical images, like tumors, which…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Zhongzhen Huang , Yankai Jiang , Rongzhao Zhang , Shaoting Zhang , Xiaofan Zhang

Accurate segmentation of medical images into anatomically meaningful regions is critical for the extraction of quantitative indices or biomarkers. The common pipeline for segmentation comprises regions of interest detection stage and…

Computer Vision and Pattern Recognition · Computer Science 2021-06-18 Ghada Zamzmi , Vandana Sachdev , Sameer Antani

Deep learning is expected to aid pathologists by automating tasks such as tumour segmentation. We aimed to develop one universal tumour segmentation model for histopathological images and examine its performance in different cancer types.…

Deep learning has gained significant attention in medical image segmentation. However, the limited availability of annotated training data presents a challenge to achieving accurate results. In efforts to overcome this challenge, data…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Pierre Vera , Su Ruan

Understanding the spatial architecture of the tumor microenvironment (TME) is critical to advance precision oncology. We present ProteinPNet, a novel framework based on prototypical part networks that discovers TME motifs from spatial…

Machine Learning · Computer Science 2025-12-03 Louis McConnell , Jieran Sun , Theo Maffei , Raphael Gottardo , Marianna Rapsomaniki

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…

Pancreatic cancer will soon be the second leading cause of cancer-related death in Western society. Imaging techniques such as CT, MRI and ultrasound typically help providing the initial diagnosis, but histopathological assessment is still…

Image and Video Processing · Electrical Eng. & Systems 2022-01-26 Pierpaolo Vendittelli , Esther M. M. Smeets , Geert Litjens

Background: A crucial initial processing step for quantitative PET/CT analysis is the segmentation of tumor lesions enabling accurate feature ex-traction, tumor characterization, oncologic staging, and image-based therapy response…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Ludovic Sibille , Xinrui Zhan , Lei Xiang

Histopathological image segmentation is a challenging and important topic in medical imaging with tremendous potential impact in clinical practice. State of the art methods rely on hand-crafted annotations which hinder clinical translation…