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Large language models (LLMs) fine-tuned with alignment techniques, such as reinforcement learning from human feedback, have been instrumental in developing some of the most capable AI systems to date. Despite their success, existing methods…

Computation and Language · Computer Science 2025-07-01 Kyuyoung Kim , Ah Jeong Seo , Hao Liu , Jinwoo Shin , Kimin Lee

Simultaneous speech translation requires accurate segmentation to balance translation quality and latency. Recent studies such as SHAS have introduced pretrained segmentation models, achieving stronger performance than heuristic rules.…

Computation and Language · Computer Science 2025-10-15 Zeyu Yang , Satoshi Nakamura

A major challenge in aligning large language models (LLMs) with human preferences is the issue of distribution shift. LLM alignment algorithms rely on static preference datasets, assuming that they accurately represent real-world user…

Machine Learning · Computer Science 2026-01-16 Zaiyan Xu , Sushil Vemuri , Kishan Panaganti , Dileep Kalathil , Rahul Jain , Deepak Ramachandran

We present Clinical Prediction with Large Language Models (CPLLM), a method that involves fine-tuning a pre-trained Large Language Model (LLM) for clinical disease and readmission prediction. We utilized quantization and fine-tuned the LLM…

Computation and Language · Computer Science 2024-05-03 Ofir Ben Shoham , Nadav Rappoport

Integrating large language models (LLMs) into healthcare holds great potential but faces challenges. Pre-training LLMs from scratch for domains like medicine is resource-heavy and often unfeasible. On the other hand, sole reliance on…

Computation and Language · Computer Science 2024-04-18 Qichen Ye , Junling Liu , Dading Chong , Peilin Zhou , Yining Hua , Fenglin Liu , Meng Cao , Ziming Wang , Xuxin Cheng , Zhu Lei , Zhenhua Guo

Trained on vast corpora, Large Language Models (LLMs) have the potential to encode visualization design knowledge and best practices. However, if they fail to do so, they might provide unreliable visualization recommendations. What…

Human-Computer Interaction · Computer Science 2024-10-22 Huichen Will Wang , Mitchell Gordon , Leilani Battle , Jeffrey Heer

To address challenges in the digital economy's landscape of digital intelligence, large language models (LLMs) have been developed. Improvements in computational power and available resources have significantly advanced LLMs, allowing their…

Computation and Language · Computer Science 2024-05-24 Yanxin Zheng , Wensheng Gan , Zefeng Chen , Zhenlian Qi , Qian Liang , Philip S. Yu

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

High-throughput phenotyping, the automated mapping of patient signs and symptoms to standardized ontology concepts, is essential to gaining value from electronic health records (EHR) in the support of precision medicine. Despite…

Artificial Intelligence · Computer Science 2024-06-24 Syed I. Munzir , Daniel B. Hier , Chelsea Oommen , Michael D. Carrithers

Personalized preference alignment for large language models (LLMs), the process of tailoring LLMs to individual users' preferences, is an emerging research direction spanning the area of NLP and personalization. In this survey, we present…

Recent developments in Direct Preference Optimization (DPO) allow large language models (LLMs) to function as implicit ranking models by maximizing the margin between preferred and non-preferred responses. In practice, user feedback on such…

Machine Learning · Computer Science 2025-09-09 Junda Wu , Rohan Surana , Zhouhang Xie , Yiran Shen , Yu Xia , Tong Yu , Ryan A. Rossi , Prithviraj Ammanabrolu , Julian McAuley

Preference modeling techniques, such as direct preference optimization (DPO), has shown effective in enhancing the generalization abilities of large language model (LLM). However, in tasks involving video instruction-following, providing…

Computer Vision and Pattern Recognition · Computer Science 2024-04-03 Ruohong Zhang , Liangke Gui , Zhiqing Sun , Yihao Feng , Keyang Xu , Yuanhan Zhang , Di Fu , Chunyuan Li , Alexander Hauptmann , Yonatan Bisk , Yiming Yang

Multimodal Large Language Models (MLLMs) are widely regarded as crucial in the exploration of Artificial General Intelligence (AGI). The core of MLLMs lies in their capability to achieve cross-modal alignment. To attain this goal, current…

Computation and Language · Computer Science 2024-11-26 Fei Zhao , Taotian Pang , Chunhui Li , Zhen Wu , Junjie Guo , Shangyu Xing , Xinyu Dai

In the past year, there has been a growing trend in applying Large Language Models (LLMs) to the field of medicine, particularly with the advent of advanced language models such as ChatGPT developed by OpenAI. However, there is limited…

Computation and Language · Computer Science 2024-02-27 Fujian Jia , Xin Liu , Lixi Deng , Jiwen Gu , Chunchao Pu , Tunan Bai , Mengjiang Huang , Yuanzhi Lu , Kang Liu

We explore the potential of Large Language Models (LLMs) to assist and potentially correct physicians in medical decision-making tasks. We evaluate several LLMs, including Meditron, Llama2, and Mistral, to analyze the ability of these…

Computation and Language · Computer Science 2024-05-07 Burcu Sayin , Pasquale Minervini , Jacopo Staiano , Andrea Passerini

Direct Preference Optimization (DPO) has emerged as an effective approach for aligning large language models (LLMs) with human preferences. However, its performance is highly dependent on the quality of the underlying human preference data.…

Machine Learning · Computer Science 2026-03-10 Zixuan Huang , Yikun Ban , Lean Fu , Xiaojie Li , Zhongxiang Dai , Jianxin Li , Deqing Wang

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical…

Artificial Intelligence · Computer Science 2026-04-10 He Geng , Yangmin Huang , Lixian Lai , Qianyun Du , Hui Chu , Zhiyang He , Jiaxue Hu , Xiaodong Tao

Alignment of large language models (LLMs) has predominantly relied on pairwise preference optimization, where annotators select the better of two responses to a prompt. While simple, this approach overlooks the opportunity to learn from…

Machine Learning · Computer Science 2026-02-11 Yuxuan Tang , Yifan Feng

Aligning large language models (LLMs) with human preferences in federated learning (FL) is challenging due to decentralized, privacy-sensitive, and highly non-IID preference data. Direct Preference Optimization (DPO) offers an efficient…

Machine Learning · Computer Science 2026-03-23 Kewen Zhu , Liping Yi , Zhiming Zhao , Zhuang Qi , Han Yu , Qinghua Hu

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

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