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The knockoff filter is a powerful tool for controlled variable selection with false discovery rate (FDR) control. In this paper, we leverage e-values to allow the nominal FDR level to be switched post-hoc, after looking at the data and…

Methodology · Statistics 2026-02-20 Lasse Fischer , Konstantinos Sechidis

In this work we study an adaptive step-down procedure for testing $m$ hypotheses. It stems from the repeated use of the false discovery rate controlling the linear step-up procedure (sometimes called BH), and makes use of the critical…

Statistics Theory · Mathematics 2009-04-01 Yulia Gavrilov , Yoav Benjamini , Sanat K. Sarkar

Deploying deep neural networks for risk-sensitive tasks necessitates an uncertainty estimation mechanism. This paper introduces hierarchical selective classification, extending selective classification to a hierarchical setting. Our…

Machine Learning · Computer Science 2025-01-07 Shani Goren , Ido Galil , Ran El-Yaniv

Out of the participants in a randomized experiment with anticipated heterogeneous treatment effects, is it possible to identify which subjects have a positive treatment effect? While subgroup analysis has received attention, claims about…

Methodology · Statistics 2024-05-14 Boyan Duan , Larry Wasserman , Aaditya Ramdas

Estimating local false discovery rates (fdr) is central to large-scale multiple hypothesis testing, yet different methods often produce divergent results, and there is little guidance for selecting among them. Because ground truth…

Methodology · Statistics 2025-09-17 Jenna M. Landy , Giovanni Parmigiani

Controlling false discovery rate (FDR) while leveraging the side information of multiple hypothesis testing is an emerging research topic in modern data science. Existing methods rely on the test-level covariates while ignoring possible…

Machine Learning · Statistics 2021-01-26 Lin Qiu , Nils Murrugarra-Llerena , Vítor Silva , Lin Lin , Vernon M. Chinchilli

We propose a general and flexible procedure for testing multiple hypotheses about sequential (or streaming) data that simultaneously controls both the false discovery rate (FDR) and false nondiscovery rate (FNR) under minimal assumptions…

Methodology · Statistics 2019-01-14 Jay Bartroff , Jinlin Song

Modern applications of conformal inference to multiple testing problems, such as outlier detection and candidate selection, often involve selecting test samples whose conformal p-values fall below a threshold. The quality of such methods is…

Methodology · Statistics 2026-05-21 Ziang Song , Ying Jin , Emmanuel J. Candès

E-processes enable hypothesis testing with ongoing data collection while maintaining Type I error control. However, when testing multiple hypotheses simultaneously, current $e$-value based multiple testing methods such as e-BH are not…

Statistics Theory · Mathematics 2025-07-18 Yury Tavyrikov , Jelle J. Goeman , Rianne de Heide

In many scientific applications, hypotheses are generated and tested continuously in a stream. We develop a framework for improving online multiple testing procedures with false discovery rate (FDR) control under arbitrary dependence. Our…

Methodology · Statistics 2026-03-27 Ziyu Xu , Lasse Fischer , Aaditya Ramdas

The success of modern machine learning hinges on access to high-quality training data. In many real-world scenarios, such as acquiring data from public repositories or sharing across institutions, data is naturally organized into discrete…

Machine Learning · Computer Science 2025-12-25 Xiaona Zhou , Yingyan Zeng , Ran Jin , Ismini Lourentzou

We introduce a novel ensemble approach for feature selection based on hierarchical stacking for non-stationarity and/or a limited number of samples with a large number of features. Our approach exploits the co-dependency between features…

Machine Learning · Computer Science 2024-10-08 Aysin Tumay , Mustafa E. Aydin , Ali T. Koc , Suleyman S. Kozat

External controls from historical trials or observational data can augment randomized controlled trials when large-scale randomization is impractical or unethical, such as in drug evaluation for rare diseases. However, non-randomized…

Methodology · Statistics 2025-05-08 Ke Zhu , Shu Yang , Xiaofei Wang

Autonomous agents can learn by imitating teacher demonstrations of the intended behavior. Hierarchical control policies are ubiquitously useful for such learning, having the potential to break down structured tasks into simpler sub-tasks,…

Machine Learning · Computer Science 2020-01-01 Roy Fox , Richard Shin , William Paul , Yitian Zou , Dawn Song , Ken Goldberg , Pieter Abbeel , Ion Stoica

Uncertainty quantification and false selection error rate (FSR) control are crucial in many high-consequence scenarios, so we need models with good interpretability. This article introduces the optimality function for the binary…

Statistics Theory · Mathematics 2023-11-08 Guanlan Zhao , Zhonggen Su

We develop a new class of distribution--free multiple testing rules for false discovery rate (FDR) control under general dependence. A key element in our proposal is a symmetrized data aggregation (SDA) approach to incorporating the…

Methodology · Statistics 2021-05-27 Lilun Du , Xu Guo , Wenguang Sun , Changliang Zou

Threshold selection plays a key role for various aspects of statistical inference of rare events. Most classical approaches tackling this problem for heavy-tailed distributions crucially depend on tuning parameters or critical values to be…

Methodology · Statistics 2019-03-07 Laura Fee Schneider , Andrea Krajina , Tatyana Krivobokova

In statistics, forecast uncertainty is often quantified using a specified statistical model, though such approaches may be vulnerable to model misspecification, selection bias, and limited finite-sample validity. While bootstrapping can…

Methodology · Statistics 2026-03-12 Han Lin Shang

We consider problems where many, somewhat redundant, hypotheses are tested and we are interested in reporting the most precise rejections, with false discovery rate (FDR) control. This is the case, for example, when researchers are…

Methodology · Statistics 2024-04-23 Paula Gablenz , Chiara Sabatti

One challenge in exploratory association studies using observational data is that the associations between the predictors and the outcome are potentially weak and rare, and the candidate predictors have complex correlation structures. False…

Methodology · Statistics 2025-01-30 Runqiu Wang , Ran Dai , Hongying Dai , Evan French , Cheng Zheng