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Brain digital twins aim to provide faithful, individualized computational representations of brains as dynamical systems, enabling mechanistic understanding and supporting prediction of clinical interventions. Yet current approaches remain…

Computational Engineering, Finance, and Science · Computer Science 2026-04-16 Alexandre Muzy

The dynamic, real-time, and accurate inference of model parameters from empirical data is of great importance in many scientific and engineering disciplines that use computational models (such as a digital twin) for the analysis and…

Signal Processing · Electrical Eng. & Systems 2020-06-11 Yuan Tian , Manuel Arias Chao , Chetan Kulkarni , Kai Goebel , Olga Fink

While simulations have been utilized in diverse domains, such as urban growth modeling, market dynamics modeling, etc; some of these applications may require validations based upon some real-world observations modeled in the simulation, as…

Multiagent Systems · Computer Science 2019-08-12 Dongjun Kim , Tae-Sub Yun , Il-Chul Moon

One of the most crucial challenges faced by the Li-ion battery community concerns the search for the minimum time charging without irreversibly damaging the cells. This can fall into solving large-scale nonlinear optimal control problems…

Systems and Control · Electrical Eng. & Systems 2020-06-26 Saehong Park , Andrea Pozzi , Michael Whitmeyer , Hector Perez , Won Tae Joe , Davide M Raimondo , Scott Moura

In this paper, we present a novel algorithm named synchronous integral Q-learning, which is based on synchronous policy iteration, to solve the continuous-time infinite horizon optimal control problems of input-affine system dynamics. The…

Systems and Control · Electrical Eng. & Systems 2021-05-20 Lei Guo , Han Zhao

We develop a parametric error model to construct a digital twin of a superconducting transmon qubit device. The model parameters are extracted from hardware calibration data and supplementary benchmarking circuits, providing a dynamic,…

Recent advances in robotics have been largely driven by imitation learning, which depends critically on large-scale, high-quality demonstration data. However, collecting such data remains a significant challenge-particularly for mobile…

Robotics · Computer Science 2025-10-07 Yilin Mei , Peng Qiu , Wei Zhang , WenChao Zhang , Wenjie Song

Bioprocess mechanistic modeling is essential for advancing intelligent digital twin representation of biomanufacturing, yet challenges persist due to complex intracellular regulation, stochastic system behavior, and limited experimental…

Machine Learning · Statistics 2025-05-07 Keilung Choy , Wei Xie , Keqi Wang

Offline reinforcement learning (RL) has achieved significant advances in domains such as robotic control, autonomous driving, and medical decision-making. Most existing methods primarily focus on training policies that maximize cumulative…

Machine Learning · Computer Science 2025-09-30 Yue Pei , Hongming Zhang , Chao Gao , Martin Müller , Mengxiao Zhu , Hao Sheng , Ziliang Chen , Liang Lin , Haogang Zhu

Digital twins are transforming engineering and applied sciences by enabling real-time monitoring, simulation, and predictive analysis of physical systems and processes. However, conventional digital twins rely primarily on passive data…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Matteo Torzoni , Domenico Maisto , Andrea Manzoni , Francesco Donnarumma , Giovanni Pezzulo , Alberto Corigliano

This work is interested in digital twins, and the development of a simplified framework for them, in the context of dynamical systems. Digital twin is an ingenious concept that helps on organizing different areas of expertise aiming at…

Signal Processing · Electrical Eng. & Systems 2021-01-29 TG Ritto , FA Rochinha

We are interested in learning models of non-stationary environments, which can be framed as a multi-task learning problem. Model-free reinforcement learning algorithms can achieve good asymptotic performance in multi-task learning at a cost…

Machine Learning · Computer Science 2020-11-24 Elahe Aghapour , Nora Ayanian

A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico…

Machine Learning · Computer Science 2024-11-04 Keying Kuang , Frances Dean , Jack B. Jedlicki , David Ouyang , Anthony Philippakis , David Sontag , Ahmed M. Alaa

Digital twins (DTs) enable powerful predictive analytics, but persistent discrepancies between simulations and real systems--known as the reality gap--undermine their reliability. Coined in robotics, the term now applies to DTs, where…

Machine Learning · Computer Science 2026-01-29 Sizhe Ma , Katherine A. Flanigan , Mario Bergés

Digital twins have become popular for their ability to monitor and optimize a process or a machine, ideally through its complete life cycle using simulations and sensor data. In this paper, we focus on the challenge of accurate and…

Systems and Control · Electrical Eng. & Systems 2023-10-30 Karim Cherifi , Philipp Schulze , Volker Mehrmann , Leo Goßlau , Pascal Lünnemann

The aim of multi-task reinforcement learning is two-fold: (1) efficiently learn by training against multiple tasks and (2) quickly adapt, using limited samples, to a variety of new tasks. In this work, the tasks correspond to reward…

Machine Learning · Computer Science 2019-11-05 Nicholas C. Landolfi , Garrett Thomas , Tengyu Ma

Model-free deep reinforcement learning (RL) algorithms have been demonstrated on a range of challenging decision making and control tasks. However, these methods typically suffer from two major challenges: very high sample complexity and…

Machine Learning · Computer Science 2018-08-10 Tuomas Haarnoja , Aurick Zhou , Pieter Abbeel , Sergey Levine

One of the key challenges in applying reinforcement learning to complex robotic control tasks is the need to gather large amounts of experience in order to find an effective policy for the task at hand. Model-based reinforcement learning…

Machine Learning · Computer Science 2016-08-12 Justin Fu , Sergey Levine , Pieter Abbeel

Advances in Automation and Artificial Intelligence continue to enhance the autonomy of process plants in handling various operational scenarios. However, certain tasks, such as fault handling, remain challenging, as they rely heavily on…

Artificial Intelligence · Computer Science 2026-02-11 Milapji Singh Gill , Javal Vyas , Artan Markaj , Felix Gehlhoff , Mehmet Mercangöz

How to obtain good value estimation is one of the key problems in Reinforcement Learning (RL). Current value estimation methods, such as DDPG and TD3, suffer from unnecessary over- or underestimation bias. In this paper, we explore the…

Machine Learning · Computer Science 2021-06-08 Jiafei Lyu , Xiaoteng Ma , Jiangpeng Yan , Xiu Li
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