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With the rapid development of deep reinforcement learning technology, it gradually demonstrates excellent potential and is becoming the most promising solution in the robotics. However, in the smart manufacturing domain, there is still not…

Robotics · Computer Science 2025-06-11 Matsive Ali , Sandesh Giri , Sen Liu , Qin Yang

Digital twins promise to revolutionize engineering by offering new avenues for optimization, control, and predictive maintenance. We propose a novel framework for simultaneously training the digital twin of an engineering system and an…

Systems and Control · Electrical Eng. & Systems 2024-07-12 Lorenzo Schena , Pedro Marques , Romain Poletti , Samuel Ahizi , Jan Van den Berghe , Miguel A. Mendez

The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational models that integrate a wide range of health-related data…

Quantitative Methods · Quantitative Biology 2025-10-21 Luis L. Fonseca , Lucas Böttcher , Borna Mehrad , Reinhard C. Laubenbacher

The evolution and growing automation of collaborative robots introduce more complexity and unpredictability to systems, highlighting the crucial need for robot's adaptability and flexibility to address the increasing complexities of their…

Robotics · Computer Science 2024-03-21 Yuzhu Sun , Mien Van , Stephen McIlvanna , Nguyen Minh Nhat , Kabirat Olayemi , Jack Close , Seán McLoone

Clinical decision support must adapt online under safety constraints. We present an online adaptive tool where reinforcement learning provides the policy, a patient digital twin provides the environment, and treatment effect defines the…

Artificial Intelligence · Computer Science 2025-08-26 Xinyu Qin , Ruiheng Yu , Lu Wang

In many industries, the scale and complexity of systems can present significant barriers to the development of accurate digital twin models. This paper introduces a novel methodology and a modular computational tool utilizing machine…

Computational Engineering, Finance, and Science · Computer Science 2025-09-23 Deniz Karanfil , Bahram Ravani

This paper introduces a sensor steering methodology based on deep reinforcement learning to enhance the predictive accuracy and decision support capabilities of digital twins by optimising the data acquisition process. Traditional sensor…

Machine Learning · Statistics 2025-05-27 Collins O. Ogbodo , Timothy J. Rogers , Mattia Dal Borgo , David J. Wagg

Biopharmaceutical manufacturing faces critical challenges, including complexity, high variability, lengthy lead time, and limited historical data and knowledge of the underlying system stochastic process. To address these challenges, we…

Machine Learning · Computer Science 2020-06-18 Hua Zheng , Wei Xie , Mingbin Ben Feng

Many industrial processes require suitable controllers to meet their performance requirements. More often, a sophisticated digital twin is available, which is a highly complex model that is a virtual representation of a given physical…

Systems and Control · Electrical Eng. & Systems 2023-11-21 Braghadeesh Lakshminarayanan , Federico Dettù , Cristian R. Rojas , Simone Formentin

Deterministic policy gradient algorithms for continuous control suffer from value estimation biases that degrade performance. While double critics reduce such biases, the exploration potential of double actors remains underexplored.…

Machine Learning · Computer Science 2025-11-21 Haohui Chen , Zhiyong Chen , Aoxiang Liu , Wentuo Fang

We propose a reinforcement learning (RL)-based algorithm to jointly train (1) a trajectory planner and (2) a tracking controller in a layered control architecture. Our algorithm arises naturally from a rewrite of the underlying optimal…

Systems and Control · Electrical Eng. & Systems 2024-12-18 Fengjun Yang , Nikolai Matni

The biopharmaceutical industry is increasingly developing digital twins to digitalize and automate the manufacturing process in response to the growing market demands. However, this shift presents significant challenges for human operators,…

Human-Computer Interaction · Computer Science 2025-04-02 Mohammed Aatif Shahab , Francesco Destro , Richard D. Braatz

Biomanufacturing innovation relies on an efficient Design of Experiments (DoEs) to optimize processes and product quality. Traditional DoE methods, ignoring the underlying bioprocessing mechanisms, often suffer from a lack of…

Quantitative Methods · Quantitative Biology 2024-07-01 Fuqiang Cheng , Wei Xie , Hua Zheng

The trend in industrial automation is towards networking, intelligence and autonomy. Digital Twins, which serve as virtual representations, are becoming increasingly important in this context. The Digital Twin of a modular production system…

Multiagent Systems · Computer Science 2022-12-08 Daniel Dittler , Peter Lierhammer , Dominik Braun , Timo Müller , Nasser Jazdi , Michael Weyrich

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

Robotic systems have become integral to smart environments, enabling applications ranging from urban surveillance and automated agriculture to industrial automation. However, their effective operation in dynamic settings - such as smart…

A properly designed controller can help improve the quality of experimental measurements or force a dynamical system to follow a completely new time-evolution path. Recent developments in deep reinforcement learning have made steep advances…

Statistical Mechanics · Physics 2025-02-26 Ruslan Mukhamadiarov

Digital twins are models of real-world systems that can simulate their dynamics in response to potential actions. In complex settings, the state and action variables, and available data and knowledge relevant to a system can constantly…

Computation and Language · Computer Science 2025-07-23 Harry Amad , Nicolás Astorga , Mihaela van der Schaar

The setup considered in the paper consists of sensors in a Networked Control System that are used to build a digital twin (DT) model of the system dynamics. The focus is on control, scheduling, and resource allocation for sensory…

Signal Processing · Electrical Eng. & Systems 2023-11-28 Van-Phuc Bui , Shashi Raj Pandey , Pedro M. de Sant Ana , Petar Popovski

Decentralised online learning enables runtime adaptation in cyber-physical multi-agent systems, but when operating conditions change, learned policies often require substantial trial-and-error interaction before recovering performance. To…

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