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Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…

Genomics · Quantitative Biology 2016-03-08 Dan Ofer

Genotype imputation enables dense variant coverage for genome-wide association and risk-prediction studies, yet conventional reference-panel methods remain limited by ancestry bias and reduced rare-variant accuracy. We present Genotype…

Graph network science is becoming increasingly popular, notably in big-data perspective where understanding individual entities for individual functional roles is complex and time consuming. It is likely when a set of genes are regulated by…

Genomics · Quantitative Biology 2021-03-11 Abhishek Narain Singh

Proteins play a vital role in biological processes and are indispensable for living organisms. Accurate representation of proteins is crucial, especially in drug development. Recently, there has been a notable increase in interest in…

Biomolecules · Quantitative Biology 2026-05-28 Dan Kalifa , Uriel Singer , Kira Radinsky

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Graph neural networks (GNNs) are shown to be successful in modeling applications with graph structures. However, training an accurate GNN model requires a large collection of labeled data and expressive features, which might be inaccessible…

Machine Learning · Computer Science 2019-06-03 Ziniu Hu , Changjun Fan , Ting Chen , Kai-Wei Chang , Yizhou Sun

Predicting the subsequent event for an existing event context is an important but challenging task, as it requires understanding the underlying relationship between events. Previous methods propose to retrieve relational features from event…

Computation and Language · Computer Science 2022-05-24 Li Du , Xiao Ding , Yue Zhang , Kai Xiong , Ting Liu , Bing Qin

Graphs can model complex relationships between objects, enabling a myriad of Web applications such as online page/article classification and social recommendation. While graph neural networks(GNNs) have emerged as a powerful tool for graph…

Machine Learning · Computer Science 2023-02-28 Zemin Liu , Xingtong Yu , Yuan Fang , Xinming Zhang

In this study, we implement a novel BERT architecture for multitask fine-tuning on three downstream tasks: sentiment classification, paraphrase detection, and semantic textual similarity prediction. Our model, Multitask BERT, incorporates…

Computation and Language · Computer Science 2024-08-29 Christopher Sun , Abishek Satish

Article prediction is a task that has long defied accurate linguistic description. As such, this task is ideally suited to evaluate models on their ability to emulate native-speaker intuition. To this end, we compare the performance of…

Computation and Language · Computer Science 2022-06-10 Harish Tayyar Madabushi , Dagmar Divjak , Petar Milin

Graph Neural Networks (GNNs) achieve strong performance on node classification tasks but remain difficult to interpret, particularly with respect to which input features drive their predictions. Existing global GNN explainers operate at the…

Machine Learning · Computer Science 2026-05-06 Rishi Raj Sahoo , Subhankar Mishra

The identification of essential genes/proteins is a critical step towards a better understanding of human biology and pathology. Computational approaches helped to mitigate experimental constraints by exploring machine learning (ML) methods…

Molecular Networks · Quantitative Biology 2021-08-02 João Schapke , Anderson Tavares , Mariana Recamonde-Mendoza

Although syntactic information is beneficial for many NLP tasks, combining it with contextual information between words to solve the coreference resolution problem needs to be further explored. In this paper, we propose an end-to-end parser…

Computation and Language · Computer Science 2023-09-12 Yuan Meng , Xuhao Pan , Jun Chang , Yue Wang

Pre-trained models for programming language have achieved dramatic empirical improvements on a variety of code-related tasks such as code search, code completion, code summarization, etc. However, existing pre-trained models regard a code…

Understanding protein structure-function relationships is a key challenge in computational biology, with applications across the biotechnology and pharmaceutical industries. While it is known that protein structure directly impacts protein…

Biomolecules · Quantitative Biology 2020-11-02 Nicolas Swenson , Aditi S. Krishnapriyan , Aydin Buluc , Dmitriy Morozov , Katherine Yelick

Relation prediction in knowledge graphs is dominated by embedding based methods which mainly focus on the transductive setting. Unfortunately, they are not able to handle inductive learning where unseen entities and relations are present…

Computation and Language · Computer Science 2021-03-15 Hanwen Zha , Zhiyu Chen , Xifeng Yan

We study the problem of incorporating prior knowledge into a deep Transformer-based model,i.e.,Bidirectional Encoder Representations from Transformers (BERT), to enhance its performance on semantic textual matching tasks. By probing and…

Computation and Language · Computer Science 2021-02-23 Tingyu Xia , Yue Wang , Yuan Tian , Yi Chang

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Genomics · Quantitative Biology 2019-06-04 Tianle Ma , Aidong Zhang

Gene studies are crucial for fields such as protein structure prediction, drug discovery, and cancer genomics, yet they face challenges in fully utilizing the vast and diverse information available. Gene studies require clean, factual…

Databases · Computer Science 2024-12-18 Yuwei Miao , Yuzhi Guo , Hehuan Ma , Jingquan Yan , Feng Jiang , Weizhi An , Jean Gao , Junzhou Huang

We introduce a new language representation model called BERT, which stands for Bidirectional Encoder Representations from Transformers. Unlike recent language representation models, BERT is designed to pre-train deep bidirectional…

Computation and Language · Computer Science 2019-05-28 Jacob Devlin , Ming-Wei Chang , Kenton Lee , Kristina Toutanova