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ARES OS 2.0 (hereinafter ARES OS) is an open-source software suite to enable laboratory automation and closed-loop autonomous experimentation. Its function is to orchestrate experimental actions and data handoff between lab equipment,…

Computational Engineering, Finance, and Science · Computer Science 2026-04-07 Arthur W. N. Sloan , Robert W. Waelder , Morgen L. Smith , Nicholas Kleiner , Arnas Babeckis , Jason Wheeler , Daylond Hooper , Benji Maruyama

In this paper we present SynKB, an open-source, automatically extracted knowledge base of chemical synthesis protocols. Similar to proprietary chemistry databases such as Reaxsys, SynKB allows chemists to retrieve structured knowledge about…

Computation and Language · Computer Science 2022-10-10 Fan Bai , Alan Ritter , Peter Madrid , Dayne Freitag , John Niekrasz

Computer-aided synthesis planning (CASP) has made significant strides in generating retrosynthetic pathways for simple molecules in a non-constrained fashion. Recent work introduces a specialised bidirectional search algorithm with forward…

Computational Engineering, Finance, and Science · Computer Science 2024-12-05 Daniel Armstrong , Zlatko Joncev , Jeff Guo , Philippe Schwaller

Computer-assisted surgical (CAS) systems enhance surgical execution and outcomes by providing advanced support to surgeons. These systems often rely on deep learning models trained on complex, challenging-to-annotate data. While synthetic…

Computer Vision and Pattern Recognition · Computer Science 2024-12-04 Sabina Martyniak , Joanna Kaleta , Diego Dall'Alba , Michał Naskręt , Szymon Płotka , Przemysław Korzeniowski

The recent advent of autonomous laboratories, coupled with algorithms for high-throughput screening and active learning, promises to accelerate materials discovery and innovation. As these autonomous systems grow in complexity, the demand…

The surge of artificial intelligence, particularly large language models, has driven the rapid development of large-scale machine learning clusters. Executing distributed models on these clusters is often constrained by communication…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-15 William Won , Midhilesh Elavazhagan , Sudarshan Srinivasan , Swati Gupta , Tushar Krishna

We introduce KAPSO, a modular framework for autonomous program synthesis and optimization. Given a natural language goal and an evaluation method, KAPSO iteratively performs ideation, code synthesis and editing, execution, evaluation, and…

Artificial Intelligence · Computer Science 2026-02-03 Alireza Nadafian , Alireza Mohammadshahi , Majid Yazdani

Retrosynthesis is the process of recursively decomposing target molecules into available building blocks. It plays an important role in solving problems in organic synthesis planning. To automate or assist in the retrosynthesis analysis,…

Quantitative Methods · Quantitative Biology 2020-11-06 Chaochao Yan , Qianggang Ding , Peilin Zhao , Shuangjia Zheng , Jinyu Yang , Yang Yu , Junzhou Huang

Probabilistic programs are key to deal with uncertainty in e.g. controller synthesis. They are typically small but intricate. Their development is complex and error prone requiring quantitative reasoning over a myriad of alternative…

Software Engineering · Computer Science 2019-04-30 Milan Češka , Christian Hensel , Sebastian Junges , Joost-Pieter Katoen

Task-based execution frameworks, such as parallel programming libraries, computational workflow systems, and function-as-a-service platforms, enable the composition of distinct tasks into a single, unified application designed to achieve a…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-15 J. Gregory Pauloski , Valerie Hayot-Sasson , Maxime Gonthier , Nathaniel Hudson , Haochen Pan , Sicheng Zhou , Ian Foster , Kyle Chard

Current computer-aided synthesis planning (CASP) methods often treat retrosynthesis as solved once a single feasible route is identified, focusing primarily on convergence or shortest-path metrics. This view is misaligned with real-world…

Artificial Intelligence · Computer Science 2026-05-27 Friedrich Hastedt , Dongda Zhang , Antonio del Rio Chanona

Retrosynthesis is the task of planning a series of chemical reactions to create a desired molecule from simpler, buyable molecules. While previous works have proposed algorithms to find optimal solutions for a range of metrics (e.g.…

Artificial Intelligence · Computer Science 2024-04-16 Austin Tripp , Krzysztof Maziarz , Sarah Lewis , Marwin Segler , José Miguel Hernández-Lobato

Retrosynthetic planning is a critical task in organic chemistry which identifies a series of reactions that can lead to the synthesis of a target product. The vast number of possible chemical transformations makes the size of the search…

Machine Learning · Computer Science 2020-06-30 Binghong Chen , Chengtao Li , Hanjun Dai , Le Song

In the current competitive environment, it is crucial for manufacturers to make the best decisions in the shortest time, in order to optimize the efficiency and effectiveness of the manufacturing systems. These decisions reach from the…

Artificial Intelligence · Computer Science 2020-06-16 Fadwa Oukhay , Pascale Zaraté , Taieb Romdhane

In the near future, autonomous space systems will compose many of the deployed spacecraft. Their tasks will involve autonomous rendezvous and proximity operations with large structures, such as inspections, assembly, and maintenance of…

Molecular simulation is a scientific tool dealing with challenges in material science and biology. This is reflected in a permanent development and enhancement of algorithms within scientific simulation packages. Here, we present…

Many Control Systems are indeed Software Based Control Systems, i.e. control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-02-25 Vadim Alimguzhin , Federico Mari , Igor Melatti , Ivano Salvo , Enrico Tronci

ESP is an open-source research platform for heterogeneous SoC design. The platform combines a modular tile-based architecture with a variety of application-oriented flows for the design and optimization of accelerators. The ESP architecture…

Constraint answer set programming or CASP, for short, is a hybrid approach in automated reasoning putting together the advances of distinct research areas such as answer set programming, constraint processing, and satisfiability modulo…

Artificial Intelligence · Computer Science 2021-07-20 Yuliya Lierler

Parallel computation is widely employed in scientific researches, engineering activities and product development. Parallel program writing itself is not always a simple task depending on problems solved. Large-scale scientific computing,…

Computational Physics · Physics 2015-03-17 Shigeo Kawata