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Background: Large language models (LLMs) show promise in medicine, but their deployment in hospitals is limited by restricted access to electronic health record (EHR) systems. The Model Context Protocol (MCP) enables integration between…

Artificial Intelligence · Computer Science 2025-09-22 Kanato Masayoshi , Masahiro Hashimoto , Ryoichi Yokoyama , Naoki Toda , Yoshifumi Uwamino , Shogo Fukuda , Ho Namkoong , Masahiro Jinzaki

This survey investigates how classical software design patterns can enhance the reliability and scalability of communication in Large Language Model (LLM)-driven agentic AI systems, focusing particularly on the Model Context Protocol (MCP).…

Software Engineering · Computer Science 2026-05-25 Anjana Sarkar , Soumyendu Sarkar

Constraint programming (CP) is a crucial technology for solving real-world constraint optimization problems (COPs), with the advantages of rich modeling semantics and high solving efficiency. Using large language models (LLMs) to generate…

Artificial Intelligence · Computer Science 2026-01-13 Weichun Shi , Minghao Liu , Wanting Zhang , Langchen Shi , Fuqi Jia , Feifei Ma , Jian Zhang

The Model Context Protocol (MCP) standardizes how large language model (LLM) agents discover, describe, and call external tools. While MCP unlocks broad interoperability, it also enlarges the attack surface by making tools first-class,…

Cryptography and Security · Computer Science 2026-03-25 Dongsen Zhang , Zekun Li , Xu Luo , Xuannan Liu , Peipei Li , Wenjun Xu

LLMs' capabilities are enhanced by using function calls to integrate various data sources or API results into the context window. Typical tools include search, web crawlers, maps, financial data, file systems, and browser usage, etc.…

Artificial Intelligence · Computer Science 2025-08-12 Shiqing Fan , Xichen Ding , Liang Zhang , Linjian Mo

Model Context Protocol (MCP) has recently gained increased attention within the AI community for providing a standardized way for large language models (LLMs) to interact with external tools and services, significantly enhancing their…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-12 Zihao Ding , Mufeng Zhu , Yao Liu

The Model Context Protocol (MCP) enables Large Language Models (LLMs) to interact with external tools via tool descriptors, thereby extending their capabilities for task execution, autonomous decision-making, and multi-agent coordination.…

Cryptography and Security · Computer Science 2026-05-22 Saeid Jamshidi , Arghavan Moradi Dakhel , Kawser Wazed Nafi , Foutse Khomh

The integration of large language models (LLMs) into scientific research is accelerating the realization of autonomous ``AI Scientists.'' While recent advancements have empowered AI to formulate hypotheses and design experiments, a critical…

Quantum Physics · Physics 2026-05-27 Masaki Shiraishi , Ikko Hamamura , Tatsuya Ishigaki , Tadashi Kadowaki

Large language model (LLM)-powered agents are increasingly used to plan and execute scientific workflows, yet most research cyberinfrastructure (CI) exposes heterogeneous APIs and implements security models that present barriers for use by…

As Model Context Protocol (MCP) introduces an easy-to-use ecosystem for users and developers, it also brings underexplored safety risks. Its decentralized architecture, which separates clients and servers, poses unique challenges for…

Computation and Language · Computer Science 2025-09-30 Huihao Jing , Haoran Li , Wenbin Hu , Qi Hu , Heli Xu , Tianshu Chu , Peizhao Hu , Yangqiu Song

Discrete Combinatorial Problems (DCPs) are prevalent in industrial decision-making and optimisation. However, while constraint solving technologies for DCPs have advanced significantly, the core process of formalising them, namely…

Artificial Intelligence · Computer Science 2026-01-29 Kostis Michailidis , Dimos Tsouros , Tias Guns

Large language models (LLMs) are evolving into agentic systems that reason, plan, and operate external tools. The Model Context Protocol (MCP) is a key enabler of this transition, offering a standardized interface for connecting LLMs with…

Computation and Language · Computer Science 2026-03-06 Xuanjun Zong , Zhiqi Shen , Lei Wang , Yunshi Lan , Chao Yang

Large Language Models (LLMs) are increasingly integrated into real-world applications via the Model Context Protocol (MCP), a universal open standard for connecting AI agents with data sources and external tools. While MCP enhances the…

Cryptography and Security · Computer Science 2026-02-13 Yixuan Yang , Cuifeng Gao , Daoyuan Wu , Yufan Chen , Yingjiu Li , Shuai Wang

To advance capabilities of large language models (LLMs) in solving combinatorial optimization problems (COPs), this paper presents the Language-based Neural COP Solver (LNCS), a novel framework that is unified for the end-to-end resolution…

Artificial Intelligence · Computer Science 2024-12-17 Xia Jiang , Yaoxin Wu , Yuan Wang , Yingqian Zhang

The Model Context Protocol (MCP), introduced by Anthropic, provides a standardized framework for artificial intelligence (AI) systems to interact with external data sources and tools in real-time. While MCP offers significant advantages for…

Cryptography and Security · Computer Science 2025-05-06 Vineeth Sai Narajala , Idan Habler

The Model Context Protocol (MCP) has been proposed as a unifying standard for connecting large language models (LLMs) with external tools and resources, promising the same role for AI integration that HTTP and USB played for the Web and…

Computers and Society · Computer Science 2025-11-18 Hechuan Guo , Yongle Hao , Yue Zhang , Minghui Xu , Peizhuo Lv , Jiezhi Chen , Xiuzhen Cheng

The Model Context Protocol (MCP) has emerged as a standardized interface enabling seamless integration between Large Language Models (LLMs) and external data sources and tools. While MCP significantly reduces development complexity and…

Cryptography and Security · Computer Science 2025-10-29 Bin Wang , Zexin Liu , Hao Yu , Ao Yang , Yenan Huang , Jing Guo , Huangsheng Cheng , Hui Li , Huiyu Wu

The Model Context Protocol (MCP) has emerged as the de facto standard for connecting Large Language Models (LLMs) to external data and tools, effectively functioning as the "USB-C for Agentic AI." While this decoupling of context and…

Cryptography and Security · Computer Science 2025-12-16 Shiva Gaire , Srijan Gyawali , Saroj Mishra , Suman Niroula , Dilip Thakur , Umesh Yadav

This paper presents the Julia package CCOpt, built on top of the interior-point solver MadNLP. CCOpt implements a suite of algorithms for Mathematical Programs with Complementarity Constraints (MPCCs). The solver additionally comes with…

Optimization and Control · Mathematics 2026-04-23 Anton Pozharskiy , François Pacaud , Moritz Diehl , Armin Nurkanović

Software development is shifting from traditional programming to AI-integrated applications that leverage generative AI and large language models (LLMs) during runtime. However, integrating LLMs remains complex, requiring developers to…