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Light microscopy is a widespread and inexpensive imaging technique facilitating biomedical discovery and diagnostics. However, light diffraction barrier and imperfections in optics limit the level of detail of the acquired images. The…

Quantitative Methods · Quantitative Biology 2026-03-24 Rui Li , Gabriel della Maggiora , Vardan Andriasyan , Anthony Petkidis , Artsemi Yushkevich , Mikhail Kudryashev , Artur Yakimovich

We present a conditional diffusion model - ConDiSim, for simulation-based inference of complex systems with intractable likelihoods. ConDiSim leverages denoising diffusion probabilistic models to approximate posterior distributions,…

Machine Learning · Computer Science 2025-10-17 Mayank Nautiyal , Andreas Hellander , Prashant Singh

In recent years we have witnessed a growth in mathematics for deep learning, which has been used to solve inverse problems of partial differential equations (PDEs). However, most deep learning-based inversion methods either require paired…

Numerical Analysis · Mathematics 2024-04-23 Enze Jiang , Jishen Peng , Zheng Ma , Xiong-Bin Yan

Diffusion probabilistic models (DPMs) represent a class of powerful generative models. Despite their success, the inference of DPMs is expensive since it generally needs to iterate over thousands of timesteps. A key problem in the inference…

Machine Learning · Computer Science 2022-05-04 Fan Bao , Chongxuan Li , Jun Zhu , Bo Zhang

Diffusion models have recently gained traction as a powerful class of deep generative priors, excelling in a wide range of image restoration tasks due to their exceptional ability to model data distributions. To solve image restoration…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Xiang Li , Soo Min Kwon , Shijun Liang , Ismail R. Alkhouri , Saiprasad Ravishankar , Qing Qu

Reconstruction-based methods have been commonly used for unsupervised anomaly detection, in which a normal image is reconstructed and compared with the given test image to detect and locate anomalies. Recently, diffusion models have shown…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Di Wu , Shicai Fan , Xue Zhou , Li Yu , Yuzhong Deng , Jianxiao Zou , Baihong Lin

We study posterior sampling for inverse problems in discrete state spaces using discrete diffusion models as generative priors. While continuous diffusion models have become widely used for inverse problems, their discrete counterparts…

Machine Learning · Computer Science 2026-05-12 Chaitanya Amballa , Sattwik Basu , Jorge Vančo Sampedro , Romit Roy Choudhury

Score-based diffusion models, which generate new data by learning to reverse a diffusion process that perturbs data from the target distribution into noise, have achieved remarkable success across various generative tasks. Despite their…

Machine Learning · Computer Science 2025-01-23 Gen Li , Yuling Yan

Analysis of galaxy--galaxy strong lensing systems is strongly dependent on any prior assumptions made about the appearance of the source. Here we present a method of imposing a data-driven prior / regularisation for source galaxies based on…

Instrumentation and Methods for Astrophysics · Physics 2022-11-09 Konstantin Karchev , Noemi Anau Montel , Adam Coogan , Christoph Weniger

Diffusion models (DMs) have recently shown outstanding capabilities in modeling complex image distributions, making them expressive image priors for solving Bayesian inverse problems. However, most existing DM-based methods rely on…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Zihui Wu , Yu Sun , Yifan Chen , Bingliang Zhang , Yisong Yue , Katherine L. Bouman

Diffusion models have been firmly established as principled zero-shot solvers for linear and nonlinear inverse problems, owing to their powerful image prior and iterative sampling algorithm. These approaches often rely on Tweedie's formula,…

Machine Learning · Computer Science 2026-04-29 Jonathan Patsenker , Henry Li , Myeongseob Ko , Ruoxi Jia , Yuval Kluger

Diffusion models have been used in cosmological applications as a generative model for fast simulations and to reconstruct underlying cosmological fields or astrophysical images from noisy data. These two tasks are often treated as…

Cosmology and Nongalactic Astrophysics · Physics 2025-02-07 Supranta S. Boruah , Michael Jacob , Bhuvnesh Jain

Diffusion probabilistic models (DPMs) have been shown to generate high-quality images without the need for delicate adversarial training. However, the current sampling process in DPMs is prone to violent shaking. In this paper, we present a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Xiyu Wang , Anh-Dung Dinh , Daochang Liu , Chang Xu

Diffusion models have emerged as a promising class of generative models that map noisy inputs to realistic images. More recently, they have been employed to generate solutions to partial differential equations (PDEs). However, they still…

Machine Learning · Computer Science 2024-02-16 Amartya Mukherjee , Melissa M. Stadt , Lena Podina , Mohammad Kohandel , Jun Liu

Diffusion models have emerged as powerful generative tools with applications in computer vision and scientific machine learning (SciML), where they have been used to solve large-scale probabilistic inverse problems. Traditionally, these…

This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…

Diffusion models have recently been shown to excel in many image reconstruction tasks that involve inverse problems based on a forward measurement operator. A common framework uses task-agnostic unconditional models that are later…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Alper Güngör , Bahri Batuhan Bilecen , Tolga Çukur

Diffusion Probabilistic Models (DPMs) have been recently utilized to deal with various blind image restoration (IR) tasks, where they have demonstrated outstanding performance in terms of perceptual quality. However, the task-specific…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Magauiya Zhussip , Iaroslav Koshelev , Stamatis Lefkimmiatis

Denoising diffusion models have driven significant progress in the field of Bayesian inverse problems. Recent approaches use pre-trained diffusion models as priors to solve a wide range of such problems, only leveraging inference-time…

Machine Learning · Statistics 2025-02-06 Yazid Janati , Badr Moufad , Mehdi Abou El Qassime , Alain Durmus , Eric Moulines , Jimmy Olsson

Restoring degraded music signals is essential to enhance audio quality for downstream music manipulation. Recent diffusion-based music restoration methods have demonstrated impressive performance, and among them, diffusion posterior…

Audio and Speech Processing · Electrical Eng. & Systems 2023-09-14 Carlos Hernandez-Olivan , Koichi Saito , Naoki Murata , Chieh-Hsin Lai , Marco A. Martínez-Ramirez , Wei-Hsiang Liao , Yuki Mitsufuji