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Current imaging methods for diagnosing BC are associated with limited sensitivity and specificity and modest positive predictive power. The recent progress in image analysis using artificial intelligence (AI) has created great promise to…

Image and Video Processing · Electrical Eng. & Systems 2024-06-24 Reza Elahi , Mahdis Nazari

Objectives: Distinguishing between radiation necrosis(RN) and metastatic progression is extremely challenging due to their similarity in conventional imaging. This is crucial from a therapeutic point of view as this determines the outcome…

Mathematical models can provide quantitative insight into immunoreceptor signaling, but require parameterization and uncertainty quantification before making reliable predictions. We review currently available methods and software tools to…

Quantitative Methods · Quantitative Biology 2019-06-28 Eshan D. Mitra , William S. Hlavacek

In this work we use variational inference to quantify the degree of uncertainty in deep learning model predictions of radio galaxy classification. We show that the level of model posterior variance for individual test samples is correlated…

Cosmology and Nongalactic Astrophysics · Physics 2022-02-09 Devina Mohan , Anna M. M. Scaife , Fiona Porter , Mike Walmsley , Micah Bowles

Uncertainty quantification (UQ) is an important component of molecular property prediction, particularly for drug discovery applications where model predictions direct experimental design and where unanticipated imprecision wastes valuable…

Machine Learning · Computer Science 2020-05-21 Lior Hirschfeld , Kyle Swanson , Kevin Yang , Regina Barzilay , Connor W. Coley

Radiomics is an active area of research focusing on high throughput feature extraction from medical images with a wide array of applications in clinical practice, such as clinical decision support in oncology. However, noise in low dose…

Quantitative Methods · Quantitative Biology 2021-09-07 Junhua Chen , Inigo Bermejo , Andre Dekker , Leonard Wee

Imbalances in covariates between treatment groups are frequent in observational studies and can lead to biased comparisons. Various adjustment methods can be employed to correct these biases in the context of multi-level treatments ($>$ 2).…

Applications · Statistics 2021-06-04 Diop S. Arona , Duchesne Thierry , Cumming Steven , Diop Awa , Talbot Denis

Accurate medical image segmentation is crucial for diagnosis and analysis. However, the models without calibrated uncertainty estimates might lead to errors in downstream analysis and exhibit low levels of robustness. Estimating the…

Image and Video Processing · Electrical Eng. & Systems 2021-09-16 Yanwu Yang , Xutao Guo , Yiwei Pan , Pengcheng Shi , Haiyan Lv , Ting Ma

Pancreatic cancers have one of the worst prognoses compared to other cancers, as they are diagnosed when cancer has progressed towards its latter stages. The current manual histological grading for diagnosing pancreatic adenocarcinomas is…

Image and Video Processing · Electrical Eng. & Systems 2022-06-20 Biraja Ghoshal , Bhargab Ghoshal , Allan Tucker

Improper pain management can lead to severe physical or mental consequences, including suffering, and an increased risk of opioid dependency. Assessing the presence and severity of pain is imperative to prevent such outcomes and determine…

Machine Learning · Computer Science 2023-11-30 Burcu Ozek , Zhenyuan Lu , Srinivasan Radhakrishnan , Sagar Kamarthi

Herein we propose a deep learning-based approach for the prediction of lung lesion response based on radiomic features extracted from clinical CT scans of patients in non-small cell lung cancer trials. The approach starts with the…

Image and Video Processing · Electrical Eng. & Systems 2020-03-09 Antong Chen , Jennifer Saouaf , Bo Zhou , Randolph Crawford , Jianda Yuan , Junshui Ma , Richard Baumgartner , Shubing Wang , Gregory Goldmacher

Uncertainty Quantification (UQ) is essential in probabilistic machine learning models, particularly for assessing the reliability of predictions. In this paper, we present a systematic framework for estimating both epistemic and aleatoric…

Machine Learning · Statistics 2025-09-11 Marzieh Ajirak , Anand Ravishankar , Petar M. Djuric

Early detection and rapid intervention of lung cancer are crucial. Nonetheless, ensuring an accurate diagnosis is challenging, as physicians' ability to interpret chest X-rays varies significantly depending on their experience and degree of…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Hyeonjin Choi , Jinse Kim , Dong-yeon Yoo , Ju-sung Sun , Jung-won Lee

Lung cancer is the leading cause for cancer related deaths. As such, there is an urgent need for a streamlined process that can allow radiologists to provide diagnosis with greater efficiency and accuracy. A powerful tool to do this is…

Computer Vision and Pattern Recognition · Computer Science 2017-03-29 Devinder Kumar , Mohammad Javad Shafiee , Audrey G. Chung , Farzad Khalvati , Masoom A. Haider , Alexander Wong

Uncertainty quantification is a central challenge in reliable and trustworthy machine learning. Naive measures such as last-layer scores are well-known to yield overconfident estimates in the context of overparametrized neural networks.…

Machine Learning · Computer Science 2023-05-24 Lucas Clarté , Bruno Loureiro , Florent Krzakala , Lenka Zdeborová

Deep learning techniques show success in detecting objects in medical images, but still suffer from false-positive predictions that may hinder accurate diagnosis. The estimated uncertainty of the neural network output has been used to flag…

Image and Video Processing · Electrical Eng. & Systems 2023-07-03 Ishaan Bhat , Josien P. W. Pluim , Max A. Viergever , Hugo J. Kuijf

Uncertainty estimation is critical for deploying reasoning language models, yet remains poorly understood under extended chain-of-thought reasoning. We study parallel sampling as a fully black-box approach using verbalized confidence and…

Artificial Intelligence · Computer Science 2026-03-20 Maksym Del , Markus Kängsepp , Marharyta Domnich , Ardi Tampuu , Lisa Yankovskaya , Meelis Kull , Mark Fishel

Radiomics analysis has emerged as a promising approach for extracting quantitative features from medical images to aid in cancer diagnosis and treatment. However, radiomics research currently lacks standardization, and radiomics features…

Evaluation of predictive deep learning (DL) models beyond conventional performance metrics has become increasingly important for applications in sensitive environments like healthcare. Such models might have the capability to encode and…

Autonomous surgical robots are a promising solution to the increasing demand for surgery amid a shortage of surgeons. Recent work has proposed learning-based approaches for the autonomous manipulation of soft tissue. However, due to…

Robotics · Computer Science 2025-08-27 Jordan Thompson , Ronald Koe , Anthony Le , Gabriella Goodman , Daniel S. Brown , Alan Kuntz