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Clinical guidelines, typically structured as decision trees, are central to evidence-based medical practice and critical for ensuring safe and accurate diagnostic decision-making. However, it remains unclear whether Large Language Models…

Computation and Language · Computer Science 2025-05-20 Xiaomin Li , Mingye Gao , Yuexing Hao , Taoran Li , Guangya Wan , Zihan Wang , Yijun Wang

In recent years, Large Language Models (LLMs) have demonstrated an impressive ability to encode knowledge during pre-training on large text corpora. They can leverage this knowledge for downstream tasks like question answering (QA), even in…

Computation and Language · Computer Science 2024-06-11 Juraj Vladika , Phillip Schneider , Florian Matthes

Large language models (LLMs) hold promise in clinical decision support but face major challenges in safety evaluation and effectiveness validation. We developed the Clinical Safety-Effectiveness Dual-Track Benchmark (CSEDB), a…

Large Language Models (LLMs) have shown growing potential in molecular sciences, but they often produce chemically inaccurate descriptions and struggle to recognize or justify potential errors. This raises important concerns about their…

Chemical Physics · Physics 2025-10-29 Yuyang Wu , Jinhui Ye , Shuhao Zhang , Lu Dai , Yonatan Bisk , Olexandr Isayev

The wide adoption of Large language models (LLMs) makes their dependability a pressing concern. Detection of errors is the first step to mitigating their impact on a system and thus, efficient error detection for LLMs is an important issue.…

Artificial Intelligence · Computer Science 2025-09-17 Jinhua Zhu , Javier Conde , Zhen Gao , Pedro Reviriego , Shanshan Liu , Fabrizio Lombardi

Objectives: To evaluate the current limitations of large language models (LLMs) in medical question answering, focusing on the quality of datasets used for their evaluation. Materials and Methods: Widely-used benchmark datasets, including…

Computation and Language · Computer Science 2025-07-15 Mahmoud Alwakeel , Aditya Nagori , Vijay Krishnamoorthy , Rishikesan Kamaleswaran

The existing methods for evaluating the medical knowledge of Large Language Models (LLMs) are largely based on atemporal examination-style benchmarks, while in reality, medical knowledge is inherently dynamic and continuously evolves as new…

Machine Learning · Computer Science 2026-05-14 Zihan Guan , Qiao Jin , Guangzhi Xiong , Fangyuan Chen , Mengxuan Hu , Qingyu Chen , Yifan Peng , Zhiyong Lu , Anil Vullikanti

Large language models (LLMs) have demonstrated powerful text generation capabilities, bringing unprecedented innovation to the healthcare field. While LLMs hold immense promise for applications in healthcare, applying them to real clinical…

Computation and Language · Computer Science 2023-10-16 Rui Yang , Edison Marrese-Taylor , Yuhe Ke , Lechao Cheng , Qingyu Chen , Irene Li

Text-guided image editing has seen significant progress in natural image domains, but its application in medical imaging remains limited and lacks standardized evaluation frameworks. Such editing could revolutionize clinical practices by…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Minghao Liu , Zhitao He , Zhiyuan Fan , Qingyun Wang , Yi R. Fung

Process-Level Reward Models (PRMs) are essential for guiding complex reasoning in large language models, yet existing PRM benchmarks cover only general domains such as mathematics, failing to address medical reasoning -- which is uniquely…

Computation and Language · Computer Science 2026-04-21 Lingyan Wu , Xiang Zheng , Weiqi Zhai , Wei Wang , Xuan Ren , Zifan Zhang , Hu Wei , Bing Zhao

Recent advances in deep research systems enable large language models to retrieve, synthesize, and reason over large-scale external knowledge. In medicine, developing clinical guidelines critically depends on such deep evidence integration.…

Large language models (LLMs) are increasingly evaluated in clinical settings using multi-dimensional rubrics which quantify reasoning quality, safety, and patient-centeredness. Yet, replicating specific mistakes in other LLM models is not…

Computation and Language · Computer Science 2026-04-08 Oleksii Proniakin , Diego Fajardo , Ruslan Nazarenko , Razvan Marinescu

Although large language models (LLMs) have been assessed for general medical knowledge using licensing exams, their ability to support clinical decision-making, such as selecting medical calculators, remains uncertain. We assessed nine…

Computation and Language · Computer Science 2025-03-25 Nicholas Wan , Qiao Jin , Joey Chan , Guangzhi Xiong , Serina Applebaum , Aidan Gilson , Reid McMurry , R. Andrew Taylor , Aidong Zhang , Qingyu Chen , Zhiyong Lu

Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

Computation and Language · Computer Science 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

As large language models (LLMs) become primary sources of health information for millions, their accuracy in women's health remains critically unexamined. We introduce the Women's Health Benchmark (WHB), the first benchmark evaluating LLM…

As Vision-Language Models (VLMs) increasingly gain traction in medical applications, clinicians are progressively expecting AI systems not only to generate textual diagnoses but also to produce corresponding medical images that integrate…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Junjie Yang , Yuhao Yan , Gang Wu , Yuxuan Wang , Ruoyu Liang , Xinjie Jiang , Xiang Wan , Fenglei Fan , Yongquan Zhang , Feiwei Qin , Changmiao Wang

Efficient hospital management systems (HMS) are critical worldwide to address challenges such as overcrowding, limited resources, and poor availability of urgent health care. Existing methods often lack the ability to provide accurate,…

Computation and Language · Computer Science 2025-09-15 Abdulrahman Allam , Seif Ahmed , Ali Hamdi , Ammar Mohammed

Advancements in Large Language Models (LLMs) and their increasing use in medical question-answering necessitate rigorous evaluation of their reliability. A critical challenge lies in hallucination, where models generate plausible yet…

Computation and Language · Computer Science 2025-02-21 Shrey Pandit , Jiawei Xu , Junyuan Hong , Zhangyang Wang , Tianlong Chen , Kaidi Xu , Ying Ding

Multimodal Large Language Models (MLLMs) have tremendous potential to improve the accuracy, availability, and cost-effectiveness of healthcare by providing automated solutions or serving as aids to medical professionals. Despite promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Mohammad Shahab Sepehri , Zalan Fabian , Maryam Soltanolkotabi , Mahdi Soltanolkotabi

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Jiyao Liu , Junzhi Ning , Chenglong Ma , Wanying Qu , Jianghan Shen , Siqi Luo , Jinjie Wei , Jin Ye , Pengze Li , Tianbin Li , Jiashi Lin , Hongming Shan , Xinzhe Luo , Xiaohong Liu , Lihao Liu , Junjun He , Ningsheng Xu
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