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Instruction-tuned large language models (LLMs) have demonstrated promising zero-shot generalization capabilities across various downstream tasks. Recent research has introduced multimodal capabilities to LLMs by integrating independently…

Computation and Language · Computer Science 2023-11-29 Utsav Garg , Erhan Bas

Despite significant achievements in improving the instruction-following capabilities of large language models (LLMs), the ability to process multiple potentially entangled or conflicting instructions remains a considerable challenge.…

Multimodal large language models are typically trained in two stages: first pre-training on image-text pairs, and then fine-tuning using supervised vision-language instruction data. Recent studies have shown that large language models can…

Machine Learning · Computer Science 2026-04-14 Lai Wei , Xiaozhe Li , Zihao Jiang , Weiran Huang , Lichao Sun

Large Language Models (LLMs) have recently shown promise in streamlining hardware design processes by encapsulating vast amounts of domain-specific data. In addition, they allow users to interact with the design processes through natural…

Machine Learning · Computer Science 2024-07-04 Yongan Zhang , Zhongzhi Yu , Yonggan Fu , Cheng Wan , Yingyan Celine Lin

Advancements in Large Language Models (LLMs) have significantly enhanced instruction-following capabilities. However, most Instruction Fine-Tuning (IFT) datasets are predominantly in English, limiting model performance in other languages.…

Computation and Language · Computer Science 2024-07-03 Sathish Reddy Indurthi , Wenxuan Zhou , Shamil Chollampatt , Ravi Agrawal , Kaiqiang Song , Lingxiao Zhao , Chenguang Zhu

Existing domain-specific Large Language Models (LLMs) are typically developed by fine-tuning general-purposed LLMs with large-scale domain-specific corpora. However, training on large-scale corpora often fails to effectively organize domain…

Computation and Language · Computer Science 2025-02-11 Zhiqiang Liu , Chengtao Gan , Junjie Wang , Yichi Zhang , Zhongpu Bo , Mengshu Sun , Huajun Chen , Wen Zhang

Large Language Models (LLMs) have demonstrated human-like instruction-following abilities, particularly those exceeding 100 billion parameters. The combined capability of some smaller, resource-friendly LLMs can address most of the…

Computation and Language · Computer Science 2025-02-25 Yi-Kai Zhang , De-Chuan Zhan , Han-Jia Ye

Instruction-tuned Large Language Models (LLMs) can perform a wide range of tasks given natural language instructions to do so, but they are sensitive to how such instructions are phrased. This issue is especially concerning in healthcare,…

We consider the protein sequence engineering problem, which aims to find protein sequences with high fitness levels, starting from a given wild-type sequence. Directed evolution has been a dominating paradigm in this field which has an…

Machine Learning · Computer Science 2025-01-20 Yinkai Wang , Jiaxing He , Yuanqi Du , Xiaohui Chen , Jianan Canal Li , Li-Ping Liu , Xiaolin Xu , Soha Hassoun

Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language, symbolic notations, with emerging extensions to incorporate multi-modal…

Machine Learning · Computer Science 2025-05-23 Ziqing Wang , Kexin Zhang , Zihan Zhao , Yibo Wen , Abhishek Pandey , Han Liu , Kaize Ding

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases…

Large language models (LLMs) have demonstrated outstanding performance in natural language processing tasks. However, in the field of recommender systems, due to the inherent structural discrepancy between user behavior data and natural…

Information Retrieval · Computer Science 2026-01-01 Zekun Liu , Xiaowen Huang , Jitao Sang

The driving factors behind the development of large language models (LLMs) with impressive learning capabilities are their colossal model sizes and extensive training datasets. Along with the progress in natural language processing, LLMs…

Computation and Language · Computer Science 2023-09-19 Thuat Nguyen , Chien Van Nguyen , Viet Dac Lai , Hieu Man , Nghia Trung Ngo , Franck Dernoncourt , Ryan A. Rossi , Thien Huu Nguyen

Large Language Models (LLMs) have demonstrated remarkable generalization and instruction-following capabilities with instruction tuning. The advancements in LLMs and instruction tuning have led to the development of Large Vision-Language…

Machine Learning · Computer Science 2024-11-05 Jinyoung Park , Minseong Bae , Dohwan Ko , Hyunwoo J. Kim

Large Language Models (LLMs) annotated datasets are widely used nowadays, however, large-scale annotations often show biases in low-quality datasets. For example, Multiple-Choice Questions (MCQs) datasets with one single correct option is…

Computation and Language · Computer Science 2026-01-08 Zipeng Ling , Shuliang Liu , Yuehao Tang , Chen Huang , Gaoyang Jiang , Shenghong Fu , Junqi Yang , Yao Wan , Jiawan Zhang , Kejia Huang , Xuming Hu

Large multimodal language models (LMMs) have achieved significant success in general domains. However, due to the significant differences between medical images and text and general web content, the performance of LMMs in medical scenarios…

Computer Vision and Pattern Recognition · Computer Science 2023-06-23 Weihao Gao , Zhuo Deng , Zhiyuan Niu , Fuju Rong , Chucheng Chen , Zheng Gong , Wenze Zhang , Daimin Xiao , Fang Li , Zhenjie Cao , Zhaoyi Ma , Wenbin Wei , Lan Ma

Open-sourced large language models (LLMs) have demonstrated remarkable efficacy in various tasks with instruction tuning. However, these models can sometimes struggle with tasks that require more specialized knowledge such as translation.…

Computation and Language · Computer Science 2024-01-23 Jiali Zeng , Fandong Meng , Yongjing Yin , Jie Zhou

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Quantitative Methods · Quantitative Biology 2024-08-14 Kamyar Zeinalipour , Neda Jamshidi , Monica Bianchini , Marco Maggini , Marco Gori
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