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Boolean networks have been successfully used in modelling gene regulatory networks. In this paper we propose a reduction method that reduces the complexity of a Boolean network but keeps dynamical properties and topological features and…

Quantitative Methods · Quantitative Biology 2009-07-06 Alan Veliz-Cuba

This paper investigates the stabilization of probabilistic Boolean networks (PBNs) via a novel pinning control strategy based on network structure. In a PBN, the evolution equation of each gene switches among a collection of candidate…

Systems and Control · Electrical Eng. & Systems 2020-10-26 Lin Lin , Jinde Cao , Jianquan Lu , Jie Zhong

In this paper, we focus on the study of quotients of Boolean control networks (BCNs) with the motivation that they might serve as smaller models that still carry enough information about the original network. Given a BCN and an equivalence…

Optimization and Control · Mathematics 2020-07-13 Rui Li , Qi Zhang , Tianguang Chu

Boolean networks (BNs) are discrete-time systems where nodes are inter-connected (here we call such connection rule among nodes as network structure), and the dynamics of each gene node is determined by logical functions. In this paper, we…

Systems and Control · Electrical Eng. & Systems 2020-11-03 Jie Zhong , Daniel W. C. Ho , Jianquan Lu

This paper investigates the problem of decomposition with respect to outputs for Boolean control networks (BCNs). First, with the linear expression of BCNs and the matrix semi-tensor product, some algebraic equivalent conditions for the…

Optimization and Control · Mathematics 2014-07-09 Yunlei Zou , Jiandong Zhu

First, the topological structure of a transition system is studied. Then, two types of transition system (TS) representations of Boolean networks (BNs) and Boolean control networks (BCNs) are investigated. The first kind of representation…

Systems and Control · Electrical Eng. & Systems 2023-04-25 Daizhan Cheng , Xiao Zhang , Zhengping Ji

The controllability and observability of Boolean control network(BCN) are two fundamental properties. But the verification of latter is much harder than the former. This paper considers the observability of BCN via controllability. First,…

Optimization and Control · Mathematics 2018-01-03 Daizhan Cheng , Changxi Li , Fenghua He

This paper presents the foundation for a decomposition theory for Boolean networks, a type of discrete dynamical system that has found a wide range of applications in the life sciences, engineering, and physics. Given a Boolean network…

Dynamical Systems · Mathematics 2022-06-10 Claus Kadelka , Reinhard Laubenbacher , David Murrugarra , Alan Veliz-Cuba , Matthew Wheeler

Probabilistic Boolean networks (PBNs) is an important mathematical framework widely used for modelling and analysing biological systems. PBNs are suited for modelling large biological systems, which more and more often arise in systems…

Computational Engineering, Finance, and Science · Computer Science 2016-05-04 Andrzej Mizera , Jun Pang , Qixia Yuan

Regulatory networks (RNs) are a well-accepted modelling formalism in computational systems biology. The control of RNs is currently receiving a lot of attention because it provides a computational basis for cell reprogramming -- an…

Systems and Control · Electrical Eng. & Systems 2022-03-01 Luboš Brim , Samuel Pastva , David Šafránek , Eva Šmijáková

There has been a recent interest in imitation learning methods that are guaranteed to produce a stabilizing control law with respect to a known system. Work in this area has generally considered linear systems and controllers, for which…

Optimization and Control · Mathematics 2021-09-23 Sebastian East

We present a notion of bisimulation that induces a reduced network which is semantically equivalent to the given neural network. We provide a minimization algorithm to construct the smallest bisimulation equivalent network. Reductions that…

Machine Learning · Computer Science 2021-11-17 Pavithra Prabhakar

In recent years, data-driven approaches have become increasingly pervasive across all areas of control engineering. However, the applications of data-based techniques to Boolean control networks (BCNs) are still very limited. In this paper…

Systems and Control · Electrical Eng. & Systems 2026-02-16 Giorgia Disarò , Maria Elena Valcher

A probabilistic structure on sequential dynamical systems is introduced here, the new model will be called Probabilistic Sequential Network, PSN. The morphisms of Probabilistic Sequential Networks are defined using two algebraic conditions.…

Genomics · Quantitative Biology 2008-04-30 Maria A. Avino-Diaz

In this paper, we study the network pinning control problem in the presence of two different types of coupling: (i) node-to-node coupling among the network nodes and (ii) input-to-node coupling from the source node to the `pinned nodes'.…

Systems and Control · Electrical Eng. & Systems 2022-11-23 Shirin Panahi , Matteo Lodi , Marco Storace , Francesco Sorrentino

The study of the interplay between the structure and dynamics of complex multilevel systems is a pressing challenge nowadays. In this paper, we use a semi-annealed approximation to study the stability properties of Random Boolean Networks…

Physics and Society · Physics 2012-10-31 Emanuele Cozzo , Alex Arenas , Yamir Moreno

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

Molecular Networks · Quantitative Biology 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

We study the problem of computing a minimal subset of nodes of a given asynchronous Boolean network that need to be controlled to drive its dynamics from an initial steady state (or attractor) to a target steady state. Due to the phenomenon…

Systems and Control · Computer Science 2018-05-18 Soumya Paul , Cui Su , Jun Pang , Andrzej Mizera

Bayesian Networks (BN) provide robust probabilistic methods of reasoning under uncertainty, but despite their formal grounds are strictly based on the notion of conditional dependence, not much attention has been paid so far to their use in…

Artificial Intelligence · Computer Science 2013-01-30 Luigi Portinale , Andrea Bobbio

Using a graph-theoretic approach, we derive a new sufficient condition for observability of a Boolean control network (BCN). Based on this condition, we describe two algorithms: the first selects a set of nodes so that observing this set…

Optimization and Control · Mathematics 2020-06-09 Eyal Weiss , Michael Margaliot
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