Related papers: On the number of $k$-mers admitting a given lexico…
In bioinformatics, minimizers have become an inescapable method for handling $k$-mers (words of fixed size $k$) extracted from DNA or RNA sequencing, whether for sampling, storage, querying or partitioning. According to some fixed order on…
Minimizers are sampling schemes with numerous applications in computational biology. Assuming a fixed alphabet of size $\sigma$, a minimizer is defined by two integers $k,w\ge2$ and a linear order $\rho$ on strings of length $k$ (also…
Minimizer schemes, or just minimizers, are a very important computational primitive in sampling and sketching biological strings. Assuming a fixed alphabet of size $\sigma$, a minimizer is defined by two integers $k,w\ge2$ and a total order…
Minimizers sampling is one of the most widely-used mechanisms for sampling strings [Roberts et al., Bioinformatics 2004]. Let $S=S[1]\ldots S[n]$ be a string over a totally ordered alphabet $\Sigma$. Further let $w\geq 2$ and $k\geq 1$ be…
A major challenge in next-generation genome sequencing (NGS) is to assemble massive overlapping short reads that are randomly sampled from DNA fragments. To complete assembling, one needs to finish a fundamental task in many leading…
Minimizers sampling is one of the most widely-used mechanisms for sampling strings. Let $S=S[0]\ldots S[n-1]$ be a string over an alphabet $\Sigma$. In addition, let $w\geq 2$ and $k\geq 1$ be two integers and $\rho=(\Sigma^k,\leq)$ be a…
For $n$ and $k$ integers we introduce the notion of some partition of $n$ being able to generate another partition of $n$. We solve the problem of finding the minimum size partition for which the set of partitions this partition can…
Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de…
Background: Short sequence substrings of a fixed length k, called k-mers, are a ubiquitous computational primitive in bioinformatics, used across sequence indexing, read mapping, genome assembly, metagenomic classification, and comparative…
We consider the {\it indexable dictionary} problem, which consists of storing a set $S \subseteq \{0,...,m-1\}$ for some integer $m$, while supporting the operations of $\Rank(x)$, which returns the number of elements in $S$ that are less…
This paper studies the minimal dimension required to embed subset memberships ($m$ elements and ${m\choose k}$ subsets of at most $k$ elements) into vector spaces, denoted as Minimal Embeddable Dimension (MED). The tight bounds of MED are…
Lexicographically minimal string rotation (LMSR) is a problem to find the minimal one among all rotations of a string in the lexicographical order, which is widely used in equality checking of graphs, polygons, automata and chemical…
Product quantization-based approaches are effective to encode high-dimensional data points for approximate nearest neighbor search. The space is decomposed into a Cartesian product of low-dimensional subspaces, each of which generates a sub…
A word $x$ that is absent from a word $y$ is called minimal if all its proper factors occur in $y$. Given a collection of $k$ words $y_1,y_2,\ldots,y_k$ over an alphabet $\Sigma$, we are asked to compute the set…
Given an edge-weighted graph, how many minimum $k$-cuts can it have? This is a fundamental question in the intersection of algorithms, extremal combinatorics, and graph theory. It is particularly interesting in that the best known bounds…
In computational biology, $k$-mers and edit distance are fundamental concepts. However, little is known about the metric space of all $k$-mers equipped with the edit distance. In this work, we explore the structure of the $k$-mer space by…
For taxonomic classification, we are asked to index the genomes in a phylogenetic tree such that later, given a DNA read, we can quickly choose a small subtree likely to contain the genome from which that read was drawn. Although popular…
A lexicographic maximum of a set $X \subseteq \mathbb{R}^n$ is a vector in $X$ whose smallest component is as large as possible, and subject to that requirement, whose second smallest component is as large as possible, and so on for the…
Minimum sum-of-squares clustering (MSSC) is a widely used clustering model, of which the popular K-means algorithm constitutes a local minimizer. It is well known that the solutions of K-means can be arbitrarily distant from the true MSSC…
In this paper we define a new problem, motivated by computational biology, $LCSk$ aiming at finding the maximal number of $k$ length $substrings$, matching in both input strings while preserving their order of appearance. The traditional…