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Modern Mixture-of-Experts (MoE) language models are designed based on total parameters (memory footprint) and active parameters (inference cost). However, we find these two factors alone are insufficient to describe an optimal architecture.…

Computation and Language · Computer Science 2026-01-14 Seng Pei Liew , Kenta Shinzato , Yuyang Dong

Machine learning methods have been used to accelerate the molecule optimization process. However, efficient search for optimized molecules satisfying several properties with scarce labeled data remains a challenge for machine learning…

Biomolecules · Quantitative Biology 2022-12-20 Xin Xia , Yansen Su , Chunhou Zheng , Xiangxiang Zeng

Nonlinear optical (NLO) materials are essential for many photonic, telecommunication, and laser technologies, yet discovering better NLO molecules is computationally challenging due to the vast chemical space and competing objectives. We…

Computational Physics · Physics 2026-05-05 Dominic Mashak , Jacob Schrum , S. A. Alexander

Optimization of materials performance for specific applications often requires balancing multiple aspects of materials functionality. Even for the cases where generative physical model of material behavior is known and reliable, this often…

Materials Science · Physics 2021-12-15 Arpan Biswas , Anna N. Morozovska , Maxim Ziatdinov , Eugene A. Eliseev , Sergei V. Kalinin

We present a new experimental design procedure that divides a set of experimental units into two groups in order to minimize error in estimating an additive treatment effect. One concern is minimizing error at the experimental design stage…

Methodology · Statistics 2021-02-02 Abba M. Krieger , David Azriel , Adam Kapelner

We study approaches to robust model-based design of experiments in the context of maximum-likelihood estimation. These approaches provide robustification of model-based methodologies for the design of optimal experiments by accounting for…

Methodology · Statistics 2021-09-03 Anwesh Reddy Gottu Mukkula , Michal Mateáš , Miroslav Fikar , Radoslav Paulen

In practical multi-criterion decision-making, it is cumbersome if a decision maker (DM) is asked to choose among a set of trade-off alternatives covering the whole Pareto-optimal front. This is a paradox in conventional evolutionary…

Neural and Evolutionary Computing · Computer Science 2022-04-07 Ke Li , Guiyu Lai , Xin Yao

dynamite is an R package for Bayesian inference of intensive panel (time series) data comprising multiple measurements per multiple individuals measured in time. The package supports joint modeling of multiple response variables,…

Methodology · Statistics 2026-01-21 Santtu Tikka , Jouni Helske

The optimization of composition and processing to obtain materials that exhibit desirable characteristics has historically relied on a combination of scientist intuition, trial and error, and luck. We propose a methodology that can…

Machine Learning · Statistics 2017-07-20 Julia Ling , Max Hutchinson , Erin Antono , Sean Paradiso , Bryce Meredig

In the era of the Big Data revolution, methods for the automatic discovery of regularities in large datasets are becoming essential tools in applied sciences. This article presents an open software package, named MODULO (MODal mULtiscale…

Data Analysis, Statistics and Probability · Physics 2020-11-12 Davide Ninni , Miguel A. Mendez

The construction of computer models (mathematical models implemented in computer codes), with respect to observed phenomena, is usually undertaken by building different variants depending on modeller sensibility, and choosing the one…

Methodology · Statistics 2018-03-28 Filippo Monari

Complex systems are often decomposed into modular subsystems for engineering tractability. Although various equation based white-box modeling techniques make use of such structure, learning based methods have yet to incorporate these ideas…

Machine Learning · Computer Science 2022-10-31 Jayesh K. Gupta , Sai Vemprala , Ashish Kapoor

Conventional Bayesian optimal experimental design seeks to maximize the expected information gain (EIG) on model parameters. However, the end goal of the experiment often is not to learn the model parameters, but to predict downstream…

Computation · Statistics 2024-08-20 Atlanta Chakraborty , Xun Huan , Tommie Catanach

The sequential parameter optimization (SPOT) package for R is a toolbox for tuning and understanding simulation and optimization algorithms. Model-based investigations are common approaches in simulation and optimization. Sequential…

Neural and Evolutionary Computing · Computer Science 2010-06-25 Thomas Bartz-Beielstein

To meet the growing demand for smarter, faster, and more efficient embodied AI solutions, we introduce a novel Mixture-of-Expert (MoE) method that significantly boosts reasoning and learning efficiency for embodied autonomous systems.…

Artificial Intelligence · Computer Science 2025-08-14 Lu Xu , Jiaqian Yu , Xiongfeng Peng , Yiwei Chen , Weiming Li , Jaewook Yoo , Sunghyun Chunag , Dongwook Lee , Daehyun Ji , Chao Zhang

The primary goal of a two-stage Phase I/II trial is to identify the optimal dose for the following large-scale Phase III trial. Recently, Phase I dose-finding designs have shifted from identifying the maximum tolerated dose (MTD) to the…

Methodology · Statistics 2025-01-16 Hao Sun , Jerry Li

A computer model can be used for predicting an output only after specifying the values of some unknown physical constants known as calibration parameters. The unknown calibration parameters can be estimated from real data by conducting…

Methodology · Statistics 2021-06-18 Arvind Krishna , V. Roshan Joseph , Shan Ba , William A. Brenneman , William R. Myers

To address the problem of combined heat and power economic emission dispatch (CHPEED), a two-stage approach is proposed by combining multi-objective optimization (MOO) with integrated decision making (IDM). First, a practical CHPEED model…

Optimization and Control · Mathematics 2018-08-22 Yang Li , Jinlong Wang , Dongbo Zhao , Guoqing Li , Chen Chen

We present a review that unifies decision-support methods for exploring the solutions produced by multi-objective optimization (MOO) algorithms. As MOO is applied to solve diverse problems, approaches for analyzing the trade-offs offered by…

Artificial Intelligence · Computer Science 2023-11-21 Zuzanna Osika , Jazmin Zatarain Salazar , Diederik M. Roijers , Frans A. Oliehoek , Pradeep K. Murukannaiah

Many-Objective Feature Selection (MOFS) approaches use four or more objectives to determine the relevance of a subset of features in a supervised learning task. As a consequence, MOFS typically returns a large set of non-dominated…

Machine Learning · Computer Science 2023-12-01 Uchechukwu F. Njoku , Alberto Abelló , Besim Bilalli , Gianluca Bontempi