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Genetic algorithms, computer programs that simulate natural evolution, are increasingly applied across many disciplines. They have been used to solve various optimisation problems from neural network architecture search to strategic games,…

Neural and Evolutionary Computing · Computer Science 2021-09-14 Aymeric Vie , Alissa M. Kleinnijenhuis , Doyne J. Farmer

Designing novel proteins with desired characteristics remains a significant challenge due to the large sequence space and the complexity of sequence-function relationships. Efficient exploration of this space to identify sequences that meet…

Machine Learning · Computer Science 2026-03-04 Erik Hartman , Di Tang , Johan Malmström

The overall aim of the software industry is to ensure delivery of high quality software to the end user. To ensure high quality software, it is required to test software. Testing ensures that software meets user specifications and…

Software Engineering · Computer Science 2014-11-06 Chayanika Sharma , Sangeeta Sabharwal , Ritu Sibal

Genetic programming (GP) is an evolutionary computation technique to solve problems in an automated, domain-independent way. Rather than identifying the optimum of a function as in more traditional evolutionary optimization, the aim of GP…

Neural and Evolutionary Computing · Computer Science 2019-05-15 Andrei Lissovoi , Pietro S. Oliveto

Genetic Algorithms (GA) are a class of metaheuristic global optimization methods inspired by the process of natural selection among individuals in a population. Despite their widespread use, a comprehensive theoretical analysis of these…

Optimization and Control · Mathematics 2025-02-24 Giacomo Borghi , Lorenzo Pareschi

In medical sciences, a biomarker is "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". Molecular…

Quantitative Methods · Quantitative Biology 2015-08-03 Frederico G. C. Arnoldi , Rodrigo F. Rodrigues , Celio L. Silva

A genetic algorithm is suitable for exploring large search spaces as it finds an approximate solution. Because of this advantage, genetic algorithm is effective in exploring vast and unknown space such as molecular search space. Though the…

Neural and Evolutionary Computing · Computer Science 2021-12-24 Yurim Lee , Gydam Choi , Minsung Yoon , Cheongwon Kim

Molecular discovery has brought great benefits to the chemical industry. Various molecule design techniques are developed to identify molecules with desirable properties. Traditional optimization methods, such as genetic algorithms,…

Biomolecules · Quantitative Biology 2025-11-05 Chris Zhuang , Debadyuti Mukherjee , Yingzhou Lu , Tianfan Fu , Ruqi Zhang

Ongoing progress in computational intelligence (CI) has led to an increased desire to apply CI techniques for the purpose of improving software engineering processes, particularly software testing. Existing state-of-the-art automated…

Neural and Evolutionary Computing · Computer Science 2023-02-16 Jarrod Goschen , Anna Sergeevna Bosman , Stefan Gruner

This paper presents a parameter-less optimization framework that uses the extended compact genetic algorithm (ECGA) and iterated local search (ILS), but is not restricted to these algorithms. The presented optimization algorithm (ILS+ECGA)…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Claudio F. Lima , Fernando G. Lobo

Gravitational-wave detection strategies are based on a signal analysis technique known as matched filtering. Despite the success of matched filtering, due to its computational cost, there has been recent interest in developing deep…

General Relativity and Quantum Cosmology · Physics 2022-11-03 Dwyer S. Deighan , Scott E. Field , Collin D. Capano , Gaurav Khanna

The main problems in modeling interacting galaxies are the extended parameter space and the fairly high CPU costs of self-consistent N-body simulations. Therefore, traditional modeling techniques suffer from either extreme CPU demands or…

Astrophysics · Physics 2007-05-23 Ch. Theis , Ch. Gerds , Ch. Spinneker

We develop a model-based methodology for integrating gene-set information with an experimentally-derived gene list. The methodology uses a previously reported sampling model, but takes advantage of natural constraints in the…

Methodology · Statistics 2015-06-02 Zhishi Wang , Qiuling He , Bret Larget , Michael A. Newton

In this work, we show how a genetic algorithm (GA) can be used to find step-by-step solutions to introductory physics problems. Our perspective is that the underlying task for this is one of finding a sequence of equations that will lead to…

Neural and Evolutionary Computing · Computer Science 2025-08-18 Tom Bensky , Justin Kopcinski

Multi-model inference covers a wide range of modern statistical applications such as variable selection, model confidence set, model averaging and variable importance. The performance of multi-model inference depends on the availability of…

Statistics Theory · Mathematics 2019-06-07 Ching-Wei Cheng , Guang Cheng

This paper presents a genetic-based hybrid algorithm that combines the exploration power of Genetic Algorithm (GA) with the exploitation capacity of a phenotypical probabilistic local search algorithm. Though not limited to a certain class…

Optimization and Control · Mathematics 2016-11-26 Reza Najian Asl , Mohamad Aslani , Masoud Shariat Panahi

Detailed models of observed interacting galaxies suffer from the extended parameter space. Here, we present results from our code MINGA which couples an evolutionary optimization strategy (a genetic algorithm) with a fast N-body method.…

Astrophysics · Physics 2009-11-10 Ch. Theis , Ch. Spinneker

We continue the study of Genetic Algorithms (GA) on combinatorial optimization problems where the candidate solutions need to satisfy a balancedness constraint. It has been observed that the reduction of the search space size granted by…

Neural and Evolutionary Computing · Computer Science 2022-06-23 Luca Manzoni , Luca Mariot , Eva Tuba

Genetic algorithms (GAs) emulate the process of biological evolution, in a computational setting, in order to generate good solutions to difficult search and optimisation problems. GA-based optimisers tend to be extremely robust and…

Instrumentation and Methods for Astrophysics · Physics 2012-02-09 Vinesh Rajpaul

In information retrieval research; Genetic Algorithms (GA) can be used to find global solutions in many difficult problems. This study used different similarity measures (Dice, Inner Product) in the VSM, for each similarity measure we…

Information Retrieval · Computer Science 2013-12-03 Eman Al Mashagba , Feras Al Mashagba , Mohammad Othman Nassar