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Nonlinear Noisy Leaky Integrate and Fire (NNLIF) models for neurons networks can be written as Fokker-Planck-Kolmogorov equations on the probability density of neurons, the main parameters in the model being the connectivity of the network…

Neurons and Cognition · Quantitative Biology 2010-10-25 María J. Cáceres , José A. Carrillo , Benoît Perthame

Predicting how systems respond to external perturbations far from equilibrium remains a fundamental challenge across physics, chemistry, and biology. We present a unified response framework for stochastic Markov dynamics that integrates…

Statistical Mechanics · Physics 2026-05-13 Jiming Zheng , Zhiyue Lu

Stochastic reaction networks is a powerful class of models for the representation a wide variety of population models including biochemistry. The control of such networks has been recently considered due to their important implications for…

Optimization and Control · Mathematics 2024-09-23 Corentin Briat , Mustafa Khammash

The dynamics of one species chemical kinetics is studied. Chemical reactions are modelled by means of continuous time Markov processes whose probability distribution obeys a suitable master equation. A large deviation theory is formally…

Statistical Mechanics · Physics 2015-03-14 Carlos Escudero , Andres M. Rivera , Pedro J. Torres

The full dynamics of a synchronous recurrent neural network model with Ising binary units and a Hebbian learning rule with a finite self-interaction is studied in order to determine the stability to synaptic and stochastic noise of…

Disordered Systems and Neural Networks · Physics 2009-11-13 F. L. Metz , W. K. Theumann

We consider the problem of estimating parameter sensitivity for Markovian models of reaction networks. Sensitivity values measure the responsiveness of an output to the model parameters. They help in analyzing the network, understanding its…

Probability · Mathematics 2014-04-18 Ankit Gupta , Mustafa Khammash

Linear conjugacy offers a new perspective to broaden the scope of stable biochemical reaction networks to the systems linearly conjugated to the well-established complex balanced mass action systems ($\ell$cCBMASs). This paper addresses the…

Dynamical Systems · Mathematics 2024-05-27 Xiaoyu Zhang , Shibo He , Chuanhou Gao , Denis Dochain

We show that discrete distributions on the $d$-dimensional non-negative integer lattice can be approximated arbitrarily well via the marginals of stationary distributions for various classes of stochastic chemical reaction networks. We…

Computational Complexity · Computer Science 2019-10-01 Daniele Cappelletti , Andrés Ortiz-Muñoz , David Anderson , Erik Winfree

Stochastic reaction networks are mathematical models frequently used in, but not limited to, biochemistry. These models are continuous-time Markov chains whose transition rates depend on certain parameters called rate constants, which…

Probability · Mathematics 2025-08-14 Daniele Cappelletti , Aidan Howells , Chuang Xu

A systematic comparison was carried out to assess the influence of representative thermostat methods in constant-temperature molecular dynamics simulations. The thermostat schemes considered include the Nos\'e--Hoover thermostat and its…

Computational Physics · Physics 2026-04-24 Kumpei Shiraishi , Emi Minamitani , Kang Kim

Stochastic models for chemical reaction networks have become very popular in recent years. For such models, the estimation of parameter sensitivities is an important and challenging problem. Sensitivity values help in analyzing the network,…

Probability · Mathematics 2013-10-08 Ankit Gupta , Mustafa Khammash

We derive a necessary and sufficient condition for Turing instabilities to occur in two-component systems of reaction-diffusion equations with Neumann boundary conditions. We apply this condition to reaction-diffusion systems built from…

Mathematical Physics · Physics 2007-05-23 Rui Dilao

We have derived exact Langevin equations for a model of quasispecies dynamics. The inherent multiplicative reaction noise is complex and its statistical properties are specified completely. The numerical simulation of the complex Langevin…

Populations and Evolution · Quantitative Biology 2007-05-23 David Hochberg , Maria-Paz Zorzano , Federico Moran

Within a fully microscopic setting, we derive a variational principle for the non-equilibrium steady states of chemical reaction networks, valid for time-scales over which chemical potentials can be taken to be slowly varying: at…

Molecular Networks · Quantitative Biology 2015-06-05 Andrea De Martino , Daniele De Martino , Roberto Mulet , Guido Uguzzoni

In the presence of multiscale dynamics in a reaction network, direct simulation methods become inefficient as they can only advance the system on the smallest scale. This work presents stochastic averaging techniques to accelerate…

Probability · Mathematics 2016-03-23 Araz Hashemi , Marcel Nunez , Petr Plechac , Dionisios G. Vlachos

We study reaction-diffusion systems beyond the Markovian approximation to take into account the effect of memory on the formation of spatio-temporal patterns. Using a non-Markovian Brusselator model as a paradigmatic example, we show how to…

Pattern Formation and Solitons · Physics 2019-12-04 Reza Torabi , Jörn Davidsen

Coupled nonlinear oscillators can exhibit a wide variety of patterns. We study the Brusselator as a prototypical autocatalytic reaction diffusion model. Working in the limit of strong nonlinearity provides a clear timescale separation that…

Pattern Formation and Solitons · Physics 2016-01-20 Daniel Goldstein , Michael Giver , Bulbul Chakraborty

In this paper, we consider a coupled Brusselator model of chemical reactions, for which no symmetry for the coupling matrices is assumed. We show that the model can undergoes a Hopf bifurcation, and consequently periodic solutions can arise…

Dynamical Systems · Mathematics 2023-05-30 Shanshan Chen , Yihuan Sun

We find that sensory noise delivered together with a weak periodic signal not only enhances nonlinear response of neuronal networks, but also improves the synchronization of the response to the signal. We reveal this phenomenon in neuronal…

Neurons and Cognition · Quantitative Biology 2015-08-25 M. A. Lopes , K. -E. Lee , A. V. Goltsev , J. F. F. Mendes

The study of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic networks are intrinsically noisy due to natural random…

Molecular Networks · Quantitative Biology 2007-05-23 Chunguang Li , Luonan Chen , Kazuyuki Aihara