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De novo drug design is a crucial component of modern drug development, yet navigating the vast chemical space to find synthetically accessible, high-affinity candidates remains a significant challenge. Reinforcement Learning (RL) enhances…

Machine Learning · Computer Science 2025-12-25 R Yadunandan , Nimisha Ghosh

Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains…

Artificial Intelligence · Computer Science 2023-07-17 Wenzhou Lv , Tianyu Wu , Luolin Xiong , Liang Wu , Jian Zhou , Yang Tang , Feng Qian

Reservoir computers (RCs) provide a computationally efficient alternative to deep learning while also offering a framework for incorporating brain-inspired computational principles. By using an internal neural network with random, fixed…

Neural and Evolutionary Computing · Computer Science 2025-04-18 Keshav Srinivasan , Dietmar Plenz , Michelle Girvan

Recent work has demonstrated the effectiveness of formulating decision making as supervised learning on offline-collected trajectories. Powerful sequence models, such as GPT or BERT, are often employed to encode the trajectories. However,…

Machine Learning · Computer Science 2023-10-31 Zilai Zeng , Ce Zhang , Shijie Wang , Chen Sun

Despite the growing prevalence of human-AI decision making, the human-AI team's decision performance often remains suboptimal, partially due to insufficient examination of humans' own reasoning. In this paper, we explore designing AI…

Human-Computer Interaction · Computer Science 2026-03-03 Harry Yizhou Tian , Hasan Amin , Ming Yin

Neuro-symbolic artificial intelligence (AI) excels at learning from noisy and generalized patterns, conducting logical inferences, and providing interpretable reasoning. Comprising a 'neuro' component for feature extraction and a 'symbolic'…

Computing systems have become increasingly complex with the emergence of heterogeneous hardware combining multicore CPUs and GPUs. These parallel systems exhibit tremendous computational power at the cost of increased programming effort.…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-02-10 Michel Steuwer , Christian Fensch , Christophe Dubach

The paradigm of Large Language Models is undergoing a fundamental transition from static inference engines to dynamic autonomous cognitive systems.While current research primarily focuses on scaling context windows or optimizing prompt…

Artificial Intelligence · Computer Science 2026-02-25 ChengYou Li , XiaoDong Liu , XiangBao Meng , XinYu Zhao

Agentic AI serving converts monolithic LLM-based inference to autonomous problem-solvers that can plan, call tools, perform reasoning, and adapt on the fly. Due to diverse task execution need, such serving heavily rely on heterogeneous…

Artificial Intelligence · Computer Science 2026-04-20 Ritik Raj , Souvik Kundu , Ishita Vohra , Hong Wang , Tushar Krishna

Artificial Intelligence is moving from models that only generate text to Agentic AI, where systems behave as autonomous entities that can perceive, reason, plan, and act. Large Language Models (LLMs) are no longer used only as passive…

Artificial Intelligence · Computer Science 2026-01-21 Arunkumar V , Gangadharan G. R. , Rajkumar Buyya

AI data centers are increasingly becoming tightly coupled compute--energy systems, where workload placement, cooling demand, electricity procurement, storage operation, and carbon emissions interact over time. This paper studies…

Computational Engineering, Finance, and Science · Computer Science 2026-05-14 Johnny R. Zhang , Gaoyuan Du , Qianyi Sun , Shiqi Wang , Jiaxuan Li , Xian Sun

Conventional algorithmic trading systems are grounded in deterministic heuristics or offline-trained statistical models that cannot adapt to the semantic complexity of rapidly shifting market regimes. This paper introduces AGENTICAITA, an…

Trading and Market Microstructure · Quantitative Finance 2026-05-14 Ivan Letteri

This paper introduces a unifying framework that links the Context-Content Uncertainty Principle (CCUP) with optimal transport (OT) via primal-dual inference. We propose that cognitive representations are not static encodings but active dual…

Neurons and Cognition · Quantitative Biology 2025-06-19 Xin Li

Active inference is a mathematical framework for understanding how agents (biological or artificial) interact with their environments, enabling continual adaptation and decision-making. It combines Bayesian inference and free energy…

Artificial Intelligence · Computer Science 2024-10-02 Rithvik Prakki

Active Inference is a closed-loop computational theoretical basis for understanding behaviour, based on agents with internal probabilistic generative models that encode their beliefs about how hidden states in their environment cause their…

Human-Computer Interaction · Computer Science 2024-12-20 Roderick Murray-Smith , John H. Williamson , Sebastian Stein

We investigate the application of active inference in developing energy-efficient control agents for manufacturing systems. Active inference, rooted in neuroscience, provides a unified probabilistic framework integrating perception,…

Machine Learning · Computer Science 2025-05-28 Yavar Taheri Yeganeh , Mohsen Jafari , Andrea Matta

The integration of Large Language Models (LLMs) into cybersecurity education for criminal justice professionals is currently hindered by the "statelessness" of reactive chatbots and the risk of hallucinations in high-stakes legal contexts.…

Human-Computer Interaction · Computer Science 2026-03-20 Baiqiang Wang , Yan Bai , Juan Li

Procedural Content Generation (PCG) refers to the practice, in videogames and other games, of generating content such as levels, quests, or characters algorithmically. Motivated by the need to make games replayable, as well as to reduce…

Artificial Intelligence · Computer Science 2020-03-18 Sebastian Risi , Julian Togelius

With recent and rapid advancements in artificial intelligence (AI), understanding the foundation of purposeful behaviour in autonomous agents is crucial for developing safe and efficient systems. While artificial neural networks have…

Artificial Intelligence · Computer Science 2025-08-12 Aswin Paul , Moein Khajehnejad , Forough Habibollahi , Brett J. Kagan , Adeel Razi

The rapid emergence of Large Language Models (LLMs) has catalyzed Agentic artificial intelligence (AI), autonomous systems integrating perception, reasoning, and action into closed-loop pipelines for continuous adaptation. While unlocking…

Systems and Control · Electrical Eng. & Systems 2026-04-10 Xiaojing Chen , Haiqi Yu , Wei Ni , Dusit Niyato , Ruichen Zhang , Xin Wang , Shunqing Zhang , Shugong Xu