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Quantum-mechanical methods are widely used for understanding molecular interactions throughout biology, chemistry, and materials science. Quantum diffusion Monte Carlo (DMC) and coupled cluster with single, double, and perturbative triple…

The small magnitude and long-range character of non-covalent interactions pose a significant challenge for computational quantum chemical and electronic-structure methods alike. State-of-the-art coupled cluster (CC) theory and…

Chemical Physics · Physics 2026-01-22 S. Lambie , P. López-Ríos , D. Kats , Ali Alavi

Reliable theoretical predictions of noncovalent interaction energies, which are important e.g. in drug-design and hydrogen-storage applications, belong to longstanding challenges of contemporary quantum chemistry. In this respect, the…

Chemical Physics · Physics 2016-06-06 Matúš Dubecký , René Derian , Petr Jurečka , Lubos Mitas , Pavel Hobza , Michal Otyepka

Diffusion quantum Monte Carlo (DMC) and coupled cluster theory [CCSD(T)] are widely-employed benchmark methods for noncovalent interactions (NCIs). However, recent studies have reported notable discrepancies across several hydrogen-bonded…

Chemical Physics · Physics 2026-04-07 Kousuke Nakano , Benjamin X. Shi , Dario Alfè , Andrea Zen

Recent disagreement between state-of-the-art quantum chemical methods, coupled cluster with single, double and perturbative triples excitations and fixed-node diffusion Monte Carlo, calls for systematic examination of possible sources of…

Chemical Physics · Physics 2025-05-14 S. Lambie , C. Rickert , D. Usvyat , A. Alavi , D. Kats

For noncovalent interactions (NCIs), the CCSD(T) coupled cluster method is widely regarded as the `gold standard'. With localized orbital approximations, benchmarks for ever larger NCI complexes are being published; yet tantalizing evidence…

Chemical Physics · Physics 2025-03-13 Vladimir Fishman , Michał Lesiuk , Jan M. L. Martin , A. Daniel Boese

For noncovalent interactions, it is generally assumed that CCSD(T) is nearly the exact solution within the 1-particle basis set. For the S66 noncovalent interactions benchmark, we present for the majority of species CCSDT and CCSDT(Q)…

Chemical Physics · Physics 2025-01-22 Emmanouil Semidalas , A. Daniel Boese , Jan M. L. Martin

In light of the recent discrepancies reported between fixed node diffusion Monte Carlo and local natural orbital coupled cluster with single, double and perturbative triples (CCSD(T)) methodologies for non-covalent interactions in large…

Chemical Physics · Physics 2024-11-22 S. Lambie , D. Kats , D. Usyvat , A. Alavi

The S66 non-covalent interactions are studied through localized coupled-cluster methods and general LNO-CCSD(T)-based composite schemes. Very small RMS deviations (\leq 0.05 kcal/mol) for the low-cost composite approaches from the SILVER…

Chemical Physics · Physics 2022-11-28 Emmanouil Semidalas , Golokesh Santra , Nisha Mehta , Jan M. L. Martin

Quantum mechanical many-electron calculations can predict properties of atoms, molecules and even complex materials. The employed computational methods play a quintessential role in many scientifically and technologically relevant research…

Chemical Physics · Physics 2025-10-22 Tobias Schäfer , Andreas Irmler , Alejandro Gallo , Andreas Grüneis

The S66 benchmark for noncovalent interactions has been re-evaluated using explicitly correlated methods with basis sets near the one-particle basis set limit. It is found that post-MP2 "high-level corrections" are treated adequately well…

Chemical Physics · Physics 2018-01-26 Manoj K. Kesharwani , Amir Karton , Nitai Sylvetsky , Jan M. L. Martin

Using the observed proportionality of CCSD(T) and MP2 correlation interaction energies [I. Grabowski, E. Fabiano, F. Della Sala, Phys. Chem. Chem. Phys. 15, 15485 (2013)] we propose a simple scaling procedure to compute accurate interaction…

Chemical Physics · Physics 2015-10-08 E. Fabiano , F. Della Sala , I. Grabowski

Noncovalent interactions--vdW dispersion, hydrogen/halogen bonding, ion-$\pi$, and $\pi$-stacking--govern structure, dynamics, and emergent phenomena in materials and molecular systems, yet accurately learning them alongside covalent forces…

Chemical Physics · Physics 2025-11-05 Leonardo Cázares-Trejo , Marco Loreto-Silva , Huziel E. Sauceda

While it is empirically accepted that the fixed-node diffusion Monte-Carlo (FN-DMC) depends only weakly on the size of the one-particle basis sets used to expand its guiding functions, limits of this observation are not settled yet. Our…

Chemical Physics · Physics 2017-02-07 Matúš Dubecký

We present two Diffusion Monte Carlo (DMC) algorithms for systems of ultracold quantum gases featuring synthetic spin-orbit interactions. The first one is a discrete spin generalization of the T- moves spin-orbit DMC, which provides an…

Quantum Gases · Physics 2018-12-05 J. Sanchez-Baena , J. Boronat , F. Mazzanti

Quantum Monte Carlo (QMC) methods are some of the most accurate methods for simulating correlated electronic systems. We investigate the compatibility, strengths and weaknesses of two such methods, namely, diffusion Monte Carlo (DMC) and…

Computational Physics · Physics 2020-10-14 Fionn D. Malone , Anouar Benali , Miguel A. Morales , Michel Caffarel , P. R. C. Kent , Luke Shulenburger

Ab initio quantum chemical methods for accurately computing interactions between molecules have a wide range of applications but are often computationally expensive. Hence, selecting an appropriate method based on accuracy and computational…

Chemical Physics · Physics 2025-11-25 Austin M. Wallace , C. David Sherrill , Giri P. Krishnan

The S66x8 noncovalent interactions benchmark has been re-evaluated at the "sterling silver" level, using explicitly correlated MP2-F12 near the complete basis set limit, CCSD(F12*)/aug-cc-pVTZ-F12, and a (T) correction from conventional…

Chemical Physics · Physics 2022-10-31 Golokesh Santra , Emmanouil Semidalas , Nisha Mehta , Amir Karton , Jan M. L. Martin

Basis set incompleteness error (BSIE) is a common source of error in quantum chemistry (QC) calculations, but it has not been comprehensively studied in fixed-node Diffusion Monte Carlo (FN-DMC) calculations. FN-DMC, being a projection…

Chemical Physics · Physics 2025-09-03 Kousuke Nakano , Benjamin X. Shi , Dario Alfè , Andrea Zen

We present a detailed study of the energetics of water clusters (H$_2$O)$_n$ with $n \le 6$, comparing diffusion Monte Carlo (DMC) and approximate density functional theory (DFT) with well converged coupled-cluster benchmarks. We use the…

Materials Science · Physics 2015-06-04 M. J. Gillan , F. R. Manby , M. D. Towler , D. Alfè
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