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Deep learning models are increasingly deployed in safety-critical applications, where reliable out-of-distribution (OOD) detection is essential to ensure robustness. Existing methods predominantly rely on the penultimate-layer activations…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Shreen Gul , Mohamed Elmahallawy , Ardhendu Tripathy , Sanjay Madria

Deep neural networks (DNNs) have the potential to power many biomedical workflows, but training them on truly representative, IID datasets is often infeasible. Most models instead rely on biased or incomplete data, making them prone to…

Machine Learning · Computer Science 2025-10-16 Yasith Jayawardana , Dineth Jayakody , Sampath Jayarathna , Dushan N. Wadduwage

Deep neural networks (DNNs) perform well at classifying inputs associated with the classes they have been trained on, which are known as in distribution inputs. However, out-of-distribution (OOD) inputs pose a great challenge to DNNs and…

Machine Learning · Computer Science 2021-02-24 Guy Amit , Moshe Levy , Ishai Rosenberg , Asaf Shabtai , Yuval Elovici

Robust out-of-distribution (OOD) detection is an indispensable component of modern artificial intelligence (AI) systems, especially in safety-critical applications where models must identify inputs from unfamiliar classes not seen during…

Machine Learning · Computer Science 2025-09-09 Tarhib Al Azad , Shahana Ibrahim

It is an important problem in trustworthy machine learning to recognize out-of-distribution (OOD) inputs which are inputs unrelated to the in-distribution task. Many out-of-distribution detection methods have been suggested in recent years.…

Machine Learning · Computer Science 2022-06-22 Julian Bitterwolf , Alexander Meinke , Maximilian Augustin , Matthias Hein

Deep neural networks for image classification only learn to map in-distribution inputs to their corresponding ground truth labels in training without differentiating out-of-distribution samples from in-distribution ones. This results from…

Machine Learning · Computer Science 2023-08-29 Zhilin Zhao , Longbing Cao , Kun-Yu Lin

Deep Neural Networks are powerful models that attained remarkable results on a variety of tasks. These models are shown to be extremely efficient when training and test data are drawn from the same distribution. However, it is not clear how…

Machine Learning · Statistics 2019-01-11 Gabi Shalev , Yossi Adi , Joseph Keshet

Previous OOD detection systems only focus on the semantic gap between ID and OOD samples. Besides the semantic gap, we are faced with two additional gaps: the domain gap between source and target domains, and the class-imbalance gap between…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Xiang Fang , Arvind Easwaran , Blaise Genest , Ponnuthurai Nagaratnam Suganthan

Deep Learning models are easily disturbed by variations in the input images that were not seen during training, resulting in unpredictable behaviours. Such Out-of-Distribution (OOD) images represent a significant challenge in the context of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Benjamin Lambert , Florence Forbes , Senan Doyle , Alan Tucholka , Michel Dojat

Despite significant advancements, segmentation based on deep neural networks in medical and surgical imaging faces several challenges, two of which we aim to address in this work. First, acquiring complete pixel-level segmentation labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Junwen Wang , Zhonghao Wang , Oscar MacCormac , Jonathan Shapey , Tom Vercauteren

Likelihood-based deep generative models such as score-based diffusion models and variational autoencoders are state-of-the-art machine learning models approximating high-dimensional distributions of data such as images, text, or audio. One…

Machine Learning · Statistics 2024-05-28 Sam Dauncey , Chris Holmes , Christopher Williams , Fabian Falck

Recent studies often exploit Graph Convolutional Network (GCN) to model label dependencies to improve recognition accuracy for multi-label image recognition. However, constructing a graph by counting the label co-occurrence possibilities of…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Jin Ye , Junjun He , Xiaojiang Peng , Wenhao Wu , Yu Qiao

This paper presents a principled approach for detecting out-of-distribution (OOD) samples in deep neural networks (DNN). Modeling probability distributions on deep features has recently emerged as an effective, yet computationally cheap…

Machine Learning · Computer Science 2020-12-09 Ibrahima Ndiour , Nilesh Ahuja , Omesh Tickoo

Modern neural networks can assign high confidence to inputs drawn from outside the training distribution, posing threats to models in real-world deployments. While much research attention has been placed on designing new out-of-distribution…

Machine Learning · Computer Science 2022-03-08 Yifei Ming , Hang Yin , Yixuan Li

Drug synergy prediction (DSP) aims to identify efficacious drug combinations under various cellular contexts with different targets. However, the continual emergence of novel compounds results in variations in molecular scaffolds and sizes,…

Machine Learning · Computer Science 2026-05-29 Xin Wang , Linxin Xiao , Yang Yao , Wenwu Zhu

Most classification and segmentation datasets assume a closed-world scenario in which predictions are expressed as distribution over a predetermined set of visual classes. However, such assumption implies unavoidable and often unnoticeable…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Petra Bevandić , Ivan Krešo , Marin Oršić , Siniša Šegvić

Training robust deep learning models is crucial in Earth Observation, where globally deployed models often face distribution shifts that degrade performance, especially in low-data regions. Out-of-distribution (OOD) detection addresses this…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Burak Ekim , Girmaw Abebe Tadesse , Caleb Robinson , Gilles Hacheme , Michael Schmitt , Rahul Dodhia , Juan M. Lavista Ferres

Detecting out-of-distribution (OOD) graphs is crucial for ensuring the safety and reliability of Graph Neural Networks. In unsupervised graph-level OOD detection, models are typically trained using only in-distribution (ID) data, resulting…

Machine Learning · Computer Science 2026-03-03 Li Sun , Lanxu Yang , Jiayu Tian , Bowen Fang , Xiaoyan Yu , Junda Ye , Peng Tang , Hao Peng , Philip S. Yu

In neuroscience, identifying distinct patterns linked to neurological disorders, such as Alzheimer's and Autism, is critical for early diagnosis and effective intervention. Graph Neural Networks (GNNs) have shown promising in analyzing…

Machine Learning · Computer Science 2025-02-05 Jiaxing Xu , Yongqiang Chen , Xia Dong , Mengcheng Lan , Tiancheng Huang , Qingtian Bian , James Cheng , Yiping Ke

Deep learning on graphs has shown remarkable success across numerous applications, including social networks, bio-physics, traffic networks, and recommendation systems. Regardless of their successes, current methods frequently depend on the…

Machine Learning · Computer Science 2025-09-25 Itay Niv , Neta Rabin