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To alleviate the burden of gathering detailed expert annotations when training deep neural networks, we propose a weakly supervised learning approach to recognize metastases in microscopic images of breast lymph nodes. We describe an…

Computer Vision and Pattern Recognition · Computer Science 2018-12-04 Shazia Akbar , Anne L. Martel

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He

Cell event detection in cell videos is essential for monitoring of cellular behavior over extended time periods. Deep learning methods have shown great success in the detection of cell events for their ability to capture more discriminative…

Computer Vision and Pattern Recognition · Computer Science 2019-09-24 Ha Tran Hong Phan , Ashnil Kumar , David Feng , Michael Fulham , Jinman Kim

The vast majority of semantic segmentation approaches rely on pixel-level annotations that are tedious and time consuming to obtain and suffer from significant inter and intra-expert variability. To address these issues, recent approaches…

Analyzing the dynamic changes of cellular morphology is important for understanding the various functions and characteristics of live cells, including stem cells and metastatic cancer cells. To this end, we need to track all points on the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Junbong Jang , Kwonmoo Lee , Tae-Kyun Kim

Metadata are general characteristics of the data in a well-curated and condensed format, and have been proven to be useful for decision making, knowledge discovery, and also heterogeneous data organization of biobank. Among all data types…

Computer Vision and Pattern Recognition · Computer Science 2019-09-18 Wei-Hung Weng , Yuannan Cai , Angela Lin , Fraser Tan , Po-Hsuan Cameron Chen

Cell detection is an essential task in cell image analysis. Recent deep learning-based detection methods have achieved very promising results. In general, these methods require exhaustively annotating the cells in an entire image. If some…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Kazuma Fujii , Daiki Suehiro , Kazuya Nishimura , Ryoma Bise

It is generally accepted that one of the critical parts of current vision algorithms based on deep learning and convolutional neural networks is the annotation of a sufficient number of images to achieve competitive performance. This is…

Computer Vision and Pattern Recognition · Computer Science 2021-03-05 Kai Yao , Alberto Ortiz , Francisco Bonnin-Pascual

Deep-learning-based pipelines have shown the potential to revolutionalize microscopy image diagnostics by providing visual augmentations to a trained pathology expert. However, to match human performance, the methods rely on the…

Weak supervision learning on classification labels has demonstrated high performance in various tasks, while a few pixel-level fine annotations are also affordable. Naturally a question comes to us that whether the combination of…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Jiahui Li , Wen Chen , Xiaodi Huang , Zhiqiang Hu , Qi Duan , Hongsheng Li , Dimitris N. Metaxas , Shaoting Zhang

Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…

Computer Vision and Pattern Recognition · Computer Science 2017-09-08 Marc Aubreville , Maximilian Krappmann , Christof Bertram , Robert Klopfleisch , Andreas Maier

Two major causes of death in the United States and worldwide are stroke and myocardial infarction. The underlying cause of both is thrombi released from ruptured or eroded unstable atherosclerotic plaques that occlude vessels in the heart…

Computer Vision and Pattern Recognition · Computer Science 2022-08-02 Nazanin Moradinasab , Yash Sharma , Laura S. Shankman , Gary K. Owens , Donald E. Brown

Obtaining large-scale medical data, annotated or unannotated, is challenging due to stringent privacy regulations and data protection policies. In addition, annotating medical images requires that domain experts manually delineate…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Tushar Kataria , Shireen Y. Elhabian

Skin cancer is one of the deadliest diseases and has a high mortality rate if left untreated. The diagnosis generally starts with visual screening and is followed by a biopsy or histopathological examination. Early detection can aid in…

Computer Vision and Pattern Recognition · Computer Science 2023-10-12 Mahapara Khurshid , Mayank Vatsa , Richa Singh

Medical image segmentation is a fundamental and critical step in many image-guided clinical approaches. Recent success of deep learning-based segmentation methods usually relies on a large amount of labeled data, which is particularly…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Rushi Jiao , Yichi Zhang , Le Ding , Rong Cai , Jicong Zhang

Polyp segmentation is a crucial step towards computer-aided diagnosis of colorectal cancer. However, most of the polyp segmentation methods require pixel-wise annotated datasets. Annotated datasets are tedious and time-consuming to produce,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Guangyu Ren , Michalis Lazarou , Jing Yuan , Tania Stathaki

Weakly supervised segmentation methods have gained significant attention due to their ability to reduce the reliance on costly pixel-level annotations during model training. However, the current weakly supervised nuclei segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-02-04 Ye Zhang , Yifeng Wang , Zijie Fang , Hao Bian , Linghan Cai , Ziyue Wang , Yongbing Zhang

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Deep Learning (DL) can predict biomarkers directly from digitized cancer histology in a weakly-supervised setting. Recently, the prediction of continuous biomarkers through regression-based DL has seen an increasing interest. Nonetheless,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-07 Omar S. M. El Nahhas , Georg Wölflein , Marta Ligero , Tim Lenz , Marko van Treeck , Firas Khader , Daniel Truhn , Jakob Nikolas Kather

End-to-end weakly supervised semantic segmentation aims at optimizing a segmentation model in a single-stage training process based on only image annotations. Existing methods adopt an online-trained classification branch to provide pseudo…

Computer Vision and Pattern Recognition · Computer Science 2023-08-10 Lei Zhu , Hangzhou He , Xinliang Zhang , Qian Chen , Shuang Zeng , Qiushi Ren , Yanye Lu