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Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity. This paper reviews the biological principles and properties of innate immunity…
The robustness of any machine learning solution is fundamentally bound by the data it was trained on. One way to generalize beyond the original training is through human-informed augmentation of the original dataset; however, it is…
Individual-based model (IBM) has been used to simulate and to design control strategies for dynamic systems that are subject to stochasticity and heterogeneity, such as infectious diseases. In the IBM, an individual is represented by a set…
Despite the remarkable generation capabilities of diffusion models, recent studies have shown that they can memorize and create harmful content when given specific text prompts. Although fine-tuning approaches have been developed to…
Recent advances in generative models have demonstrated remarkable capabilities in producing high-quality images, but their reliance on large-scale unlabeled data has raised significant safety and copyright concerns. Efforts to address these…
Adapting general-purpose language models to new skills is currently an expensive process that must be repeated as new instruction datasets targeting new skills are created, or can cause the models to forget older skills. In this work, we…
In the era of deep learning, the increasing number of pre-trained models available online presents a wealth of knowledge. These models, developed with diverse architectures and trained on varied datasets for different tasks, provide unique…
We consider scenarios where a very accurate (often small) predictive model using restricted features is available when training a full-featured (often larger) model. This restricted model may be thought of as side-information'', and can…
In this review we make the statement that hybrid models in oncology are required as a mean for enhanced data integration. In the context of systems oncology, experimental and clinical data need to be at the heart of the models developments…
In this article I describe a research agenda for securing machine learning models against adversarial inputs at test time. This article does not present results but instead shares some of my thoughts about where I think that the field needs…
Complex systems' modeling and simulation are powerful ways to investigate a multitude of natural phenomena providing extended knowledge on their structure and behavior. However, enhanced modeling and simulation require integration of…
This paper investigates the conceptual relationship between openness and reproducibility using a model-centric approach, heavily informed by probability theory and statistics. We first clarify the concepts of reliability, auditability,…
When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient of the outcome model targets a…
Transfer-learning and meta-learning are two effective methods to apply knowledge learned from large data sources to new tasks. In few-class, few-shot target task settings (i.e. when there are only a few classes and training examples…
Privacy data protection in the medical field poses challenges to data sharing, limiting the ability to integrate data across hospitals for training high-precision auxiliary diagnostic models. Traditional centralized training methods are…
Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…
This paper introduces Multi-Garment Customized Model Generation, a unified framework based on Latent Diffusion Models (LDMs) aimed at addressing the unexplored task of synthesizing images with free combinations of multiple pieces of…
With the recent wave of digitalization, specifically in the context of safety-critical applications, there has been a growing need for computationally efficient, accurate, generalizable, and trustworthy models. Physics-based models have…
We present a novel methodology for integrating high resolution longitudinal data with the dynamic prediction capabilities of survival models. The aim is two-fold: to improve the predictive power while maintaining interpretability of the…
Model merging, which combines multiple domain-specialized experts into a single model, offers a practical path to endow Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) with broad capabilities without the cost of…