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Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery that recognizes and corrects specific errors. Here we study…

Populations and Evolution · Quantitative Biology 2026-05-14 Riccardo Ravasio , Kabir Husain , Constantine G. Evans , Rob Phillips , Marco Ribezzi-Crivellari , Jack W. Szostak , Arvind Murugan

Processes controlled by stochastic synthesis and degradation (SSD) are widespread in biology but their reaction kinetics are not well understood. Using methods borrowed from the theory of resetting processes, we determine the first-passage…

Statistical Mechanics · Physics 2026-02-12 Gabriel Mercado-Vásquez , Denis Boyer

Stochastic optimization problems often involve data distributions that change in reaction to the decision variables. This is the case for example when members of the population respond to a deployed classifier by manipulating their features…

Optimization and Control · Mathematics 2020-12-15 Dmitriy Drusvyatskiy , Lin Xiao

We consider a stochastic, dynamic job scheduling problem, formulated as a queueing control problem, in which a single server processes jobs of different types that arrive according to independent Poisson processes. The problem is defined on…

Optimization and Control · Mathematics 2025-09-09 Dongnuan Tian , Rob Shone

In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint…

Computational Engineering, Finance, and Science · Computer Science 2011-09-08 Luca Bortolussi , Alberto Policriti

Stochastic resetting has emerged as a useful strategy to reduce the completion time for a broad class of first passage processes. In the canonical setup, one intermittently resets a given system to its initial configuration only to start…

Statistical Mechanics · Physics 2025-01-28 Arup Biswas , Ashutosh Dubey , Anupam Kundu , Arnab Pal

Machine learning practitioners invest significant manual and computational resources in finding suitable learning rates for optimization algorithms. We provide a probabilistic motivation, in terms of Gaussian inference, for popular…

Machine Learning · Computer Science 2021-02-23 Filip de Roos , Carl Jidling , Adrian Wills , Thomas Schön , Philipp Hennig

Increasing effort is put into the development of methods for learning mechanistic models from data. This task entails not only the accurate estimation of parameters but also a suitable model structure. Recent work on the discovery of…

Machine Learning · Computer Science 2024-07-01 Justin N. Kreikemeyer , Philipp Andelfinger , Adelinde M. Uhrmacher

Stochastic processes generated by non-stationary distributions are difficult to represent with conventional models such as Gaussian processes. This work presents Recurrent Autoregressive Flows as a method toward general stochastic process…

Machine Learning · Computer Science 2020-06-20 John Mern , Peter Morales , Mykel J. Kochenderfer

Many cell populations, exemplified by certain tumors, grow approximately according to a Gompertzian growth model which has a slower approach to an upper limit than that of logistic growth. Certain populations of animals and other organisms…

Populations and Evolution · Quantitative Biology 2016-05-02 Henry C. Tuckwell

Stochastic resetting breaks detailed balance and drives the formation of nonequilibrium steady states . Here, we consider a chain of diffusive processes $x_i(t)$ that interact unilaterally: at random time intervals, the process $x_n$…

Statistical Mechanics · Physics 2025-02-06 Henry Alston , Callum Britton , Thibault Bertrand

It is widely acknowledged that large and sparse models have higher accuracy than small and dense models under the same model size constraints. This motivates us to train a large model and then remove its redundant neurons or weights by…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Jianwei Li , Weizhi Gao , Qi Lei , Dongkuan Xu

We consider the problem of diffusion with stochastic resetting in a population of random walks where the diffusion coefficient is not constant, but behaves as a power-law of the average resetting rate of the population. Resetting occurs…

Statistical Mechanics · Physics 2022-09-07 Eric Bertin

Stochastic processes have found numerous applications in science, as they are broadly used to model a variety of natural phenomena. Due to their intrinsic randomness and uncertainty, they are, however, difficult to characterize. Here, we…

We study the problem of learning to choose from m discrete treatment options (e.g., news item or medical drug) the one with best causal effect for a particular instance (e.g., user or patient) where the training data consists of passive…

Machine Learning · Statistics 2017-08-02 Nathan Kallus

We consider a hierarchically structured population in which the amount of resources an individual has access to is affected by individuals that are larger, and that the intake of resources by an individual only affects directly the growth…

Analysis of PDEs · Mathematics 2024-07-15 Carles Barril , Àngel Calsina , József Z. Farkas

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

Probability · Mathematics 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard

We study the counting of level crossings for inertial random processes exposed to stochastic resetting events. We develop the general approach of stochastic resetting for inertial processes with sudden changes in the state characterized by…

Statistical Mechanics · Physics 2023-12-22 Miquel Montero , Matteo Palassini , Jaume Masoliver

Restart is a general framework, of prime importance and wide applicability, for expediting first-passage times and completion times of general stochastic processes. Restart protocols can use either deterministic or stochastic timers.…

Statistical Mechanics · Physics 2020-10-27 Iddo Eliazar , Shlomi Reuveni

Stochastic models of surface growth are usually based on randomly choosing a substrate site to perform iterative steps, as in the etching model [1]. In this paper I modify the etching model to perform sequential, instead of random,…

Statistical Mechanics · Physics 2017-07-19 Bernardo A. Mello