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Understanding disease-gene associations is essential for unravelling disease mechanisms and advancing diagnostics and therapeutics. Traditional approaches based on manual curation and literature review are labour-intensive and not scalable,…

Machine Learning · Computer Science 2026-02-24 Osman Onur Kuzucu , Tunca Doğan

Deep neural network learning can be formulated as a non-convex optimization problem. Existing optimization algorithms, e.g., Adam, can learn the models fast, but may get stuck in local optima easily. In this paper, we introduce a novel…

Machine Learning · Computer Science 2019-03-12 Jiawei Zhang , Fisher B. Gouza

Aim/Introduction: Distance-encoding biomorphic-informational neural network (DEBI-NN) is a recently proposed architecture in which connection weights are defined by the distances between neurons positioned in a Euclidian space. This…

Neural and Evolutionary Computing · Computer Science 2026-05-28 Amine Boukhari , Boglarka Ecsedi , Laszlo Papp , Mathieu Hatt

Cardiovascular diseases (CVDs) are any serious illness of the heart, which require accurate diagnosis to prevent fatal consequences. Hyperparameter tuning plays a critical role in optimizing machine learning model performance by selecting…

Machine Learning · Computer Science 2026-05-19 Abhay Kumar Pathak , Mrityunjay Chaubey , Manjari Gupta

Genomic datasets contain the effects of various unobserved biological variables in addition to the variable of primary interest. These latent variables often affect a large number of features (e.g., genes) and thus give rise to dense latent…

Applications · Statistics 2021-11-02 Nora Yujia Payne , Johann A. Gagnon-Bartsch

The identification of essential genes/proteins is a critical step towards a better understanding of human biology and pathology. Computational approaches helped to mitigate experimental constraints by exploring machine learning (ML) methods…

Molecular Networks · Quantitative Biology 2021-08-02 João Schapke , Anderson Tavares , Mariana Recamonde-Mendoza

Incorporating biological neuronal properties into Artificial Neural Networks (ANNs) to enhance computational capabilities poses a formidable challenge in the field of machine learning. Inspired by recent findings indicating that dendrites…

Neural and Evolutionary Computing · Computer Science 2023-07-26 Chongming Liu , Songting Li , Douglas Zhou

Automatic modulation classification (AMC) is a promising technology to realize intelligent wireless communications in the sixth generation (6G) wireless communication networks. Recently, many data-and-knowledge dual-driven AMC schemes have…

Signal Processing · Electrical Eng. & Systems 2024-03-04 Yike Li , Lu Yua , Fuhui Zhou , Qihui Wu , Naofal Al-Dhahir , Kai-Kit Wong

The LIDC-IDRI database is the most popular benchmark for lung cancer prediction. However, with subjective assessment from radiologists, nodules in LIDC may have entirely different malignancy annotations from the pathological ground truth,…

Image and Video Processing · Electrical Eng. & Systems 2022-07-29 Hanxiao Zhang , Xiao Gu , Minghui Zhang , Weihao Yu , Liang Chen , Zhexin Wang , Feng Yao , Yun Gu , Guang-Zhong Yang

Application of Genetic Algorithm (GA) for determination of parameters of an analytical representation of diatomic molecule potential is presented. GA can be used for finding potential characteristics of an electronic energy state which can…

Chemical Physics · Physics 2020-05-12 Tomasz Urbanczyk , Jaroslaw Koperski

Decentralized learning enables a group of collaborative agents to learn models using a distributed dataset without the need for a central parameter server. Recently, decentralized learning algorithms have demonstrated state-of-the-art…

Machine Learning · Computer Science 2021-06-30 Yasaman Esfandiari , Sin Yong Tan , Zhanhong Jiang , Aditya Balu , Ethan Herron , Chinmay Hegde , Soumik Sarkar

Genetic algorithm (GA) is an efficient tool for solving optimization problems by evolving solutions, as it mimics the Darwinian theory of natural evolution. The mutation operator is one of the key success factors in GA, as it is considered…

Neural and Evolutionary Computing · Computer Science 2018-01-23 Esra'a Alkafaween , Ahmad B. A. Hassanat

Ventricular arrhythmias (VA) are the main causes of sudden cardiac death. Developing machine learning methods for detecting VA based on electrocardiograms (ECGs) can help save people's lives. However, developing such machine learning models…

Machine Learning · Computer Science 2022-03-02 Wenrui Zhang , Shijia Geng , Zhaoji Fu , Linlin Zheng , Chenyang Jiang , Shenda Hong

Genetic Algorithms (GA) are a class of metaheuristic global optimization methods inspired by the process of natural selection among individuals in a population. Despite their widespread use, a comprehensive theoretical analysis of these…

Optimization and Control · Mathematics 2025-02-24 Giacomo Borghi , Lorenzo Pareschi

Cardiac diseases are among the leading causes of morbidity and mortality worldwide, which requires accurate and timely diagnostic strategies. In this study, we introduce an innovative approach that combines deep learning image registration…

Machine Learning · Computer Science 2025-07-09 Comte Valentin , Gemma Piella , Mario Ceresa , Miguel A. Gonzalez Ballester

In terms of Generative Adversarial Networks (GANs), the information metric to discriminate the generative data from the real data, lies in the key point of generation efficiency, which plays an important role in GAN-based applications,…

Machine Learning · Computer Science 2021-01-08 Rui She , Pingyi Fan

Automated heart sounds classification is a much-required diagnostic tool in the view of increasing incidences of heart related diseases worldwide. In this study, we conduct a comprehensive study of heart sounds classification by using…

Computer Vision and Pattern Recognition · Computer Science 2020-06-05 Balagopal Unnikrishnan , Pranshu Ranjan Singh , Xulei Yang , Matthew Chin Heng Chua

Deep neural networks suffer from poor generalization to unseen environments when the underlying data distribution is different from that in the training set. By learning minimum sufficient representations from training data, the information…

Machine Learning · Computer Science 2021-10-13 Francesco Alesiani , Shujian Yu , Xi Yu

The integration of knowledge graphs and graph machine learning (GML) in genomic data analysis offers several opportunities for understanding complex genetic relationships, especially at the RNA level. We present a comprehensive approach for…

Artificial Intelligence · Computer Science 2024-08-06 Shivika Prasanna , Ajay Kumar , Deepthi Rao , Eduardo Simoes , Praveen Rao

Neural networks require a large amount of annotated data to learn. Meta-learning algorithms propose a way to decrease the number of training samples to only a few. One of the most prominent optimization-based meta-learning algorithms is…

Machine Learning · Computer Science 2022-06-14 Kostiantyn Khabarlak