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Statistical inference on the cancer-site specificities of collective ultra-rare whole genome somatic mutations is an open problem. Traditional statistical methods cannot handle whole-genome mutation data due to their…

Methodology · Statistics 2023-01-02 Saptarshi Chakraborty , Zoe Guan , Colin B. Begg , Ronglai Shen

Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep…

Genomics · Quantitative Biology 2025-08-06 Vinil Polepalli

Meta-learning offers a promising avenue for few-shot learning (FSL), enabling models to glean a generalizable feature embedding through episodic training on synthetic FSL tasks in a source domain. Yet, in practical scenarios where the…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Fei Zhou , Peng Wang , Lei Zhang , Zhenghua Chen , Wei Wei , Chen Ding , Guosheng Lin , Yanning Zhang

Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment…

Real-world application of chest X-ray abnormality classification requires dealing with several challenges: (i) limited training data; (ii) training and evaluation sets that are derived from different domains; and (iii) classes that appear…

Computer Vision and Pattern Recognition · Computer Science 2023-09-11 Aroof Aimen , Arsh Verma , Makarand Tapaswi , Narayanan C. Krishnan

Object detection, segmentation and classification are three common tasks in medical image analysis. Multi-task deep learning (MTL) tackles these three tasks jointly, which provides several advantages saving computing time and resources and…

Computer Vision and Pattern Recognition · Computer Science 2019-06-06 Fei Gao , Hyunsoo Yoon , Teresa Wu , Xianghua Chu

Prototype is widely used to represent internal structure of category for few-shot learning, which was proposed as a simple inductive bias to address the issue of overfitting. However, since prototype representation is normally averaged from…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Tao Zhang , Wu Huang

Graph Self-Supervised Learning (GSSL) provides a robust pathway for acquiring embeddings without expert labelling, a capability that carries profound implications for molecular graphs due to the staggering number of potential molecules and…

Machine Learning · Computer Science 2023-10-19 Hanchen Wang , Jean Kaddour , Shengchao Liu , Jian Tang , Joan Lasenby , Qi Liu

We propose to address the problem of few-shot classification by meta-learning "what to observe" and "where to attend" in a relational perspective. Our method leverages relational patterns within and between images via self-correlational…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Dahyun Kang , Heeseung Kwon , Juhong Min , Minsu Cho

Determining early-stage prognostic markers and stratifying patients for effective treatment are two key challenges for improving outcomes for melanoma patients. Previous studies have used tumour transcriptome data to stratify patients into…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Lucy Godson , Navid Alemi , Jeremie Nsengimana , Graham P. Cook , Emily L. Clarke , Darren Treanor , D. Timothy Bishop , Julia Newton-Bishop , Ali Gooya

Few-shot classification aims to learn to classify new object categories well using only a few labeled examples. Transferring feature representations from other models is a popular approach for solving few-shot classification problems. In…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Chun-Nam Yu , Yi Xie

The implementation of deep learning based computer aided diagnosis systems for the classification of mammogram images can help in improving the accuracy, reliability, and cost of diagnosing patients. However, training a deep learning model…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Saul Calderon-Ramirez , Diego Murillo-Hernandez , Kevin Rojas-Salazar , David Elizondo , Shengxiang Yang , Miguel Molina-Cabello

Rare cancers comprise 20-25% of all malignancies but face major diagnostic challenges due to limited expert availability-especially in pediatric oncology, where they represent over 70% of cases. While pathology vision-language (VL)…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Dexuan He , Xiao Zhou , Wenbin Guan , Liyuan Zhang , Xiaoman Zhang , Sinuo Xu , Ge Wang , Lifeng Wang , Xiaojun Yuan , Xin Sun , Yanfeng Wang , Kun Sun , Ya Zhang , Weidi Xie

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He

Few-shot learning has become essential for producing models that generalize from few examples. In this work, we identify that metric scaling and metric task conditioning are important to improve the performance of few-shot algorithms. Our…

Machine Learning · Computer Science 2019-01-28 Boris N. Oreshkin , Pau Rodriguez , Alexandre Lacoste

The performance of meta-learning approaches for few-shot learning generally depends on three aspects: features suitable for comparison, the classifier ( base learner ) suitable for low-data scenarios, and valuable information from the…

Machine Learning · Computer Science 2020-09-15 Haoqing Wang , Zhi-Hong Deng

Deep neural networks (DNNs) have achieved state-of-the-art results on time series classification (TSC) tasks. In this work, we focus on leveraging DNNs in the often-encountered practical scenario where access to labeled training data is…

Machine Learning · Computer Science 2021-03-05 Jyoti Narwariya , Pankaj Malhotra , Lovekesh Vig , Gautam Shroff , Vishnu Tv

The aim of Few-Shot learning methods is to train models which can easily adapt to previously unseen tasks, based on small amounts of data. One of the most popular and elegant Few-Shot learning approaches is Model-Agnostic Meta-Learning…

Machine Learning · Computer Science 2024-07-09 M. Przewięźlikowski , P. Przybysz , J. Tabor , M. Zięba , P. Spurek

The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning…

Recently, therapeutic peptides have demonstrated great promise for cancer treatment. To explore powerful anticancer peptides, artificial intelligence (AI)-based approaches have been developed to systematically screen potential candidates.…

Quantitative Methods · Quantitative Biology 2025-04-16 Joshua Zhi En Tan , JunJie Wee , Xue Gong , Kelin Xia
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