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Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-08 Yijie Zhang , Kevin de Haan , Yair Rivenson , Jingxi Li , Apostolos Delis , Aydogan Ozcan

In digital pathology, acquiring all-in-focus images is essential to high-quality imaging and high-efficient clinical workflow. Traditional scanners achieve this by scanning at multiple focal planes of varying depths and then merging them,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Jiangdong Cai , Yan Chen , Zhenrong Shen , Haotian Jiang , Honglin Xiong , Kai Xuan , Lichi Zhang , Qian Wang

How does one adapt a pre-trained visual model to novel downstream tasks without task-specific finetuning or any model modification? Inspired by prompting in NLP, this paper investigates visual prompting: given input-output image example(s)…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 Amir Bar , Yossi Gandelsman , Trevor Darrell , Amir Globerson , Alexei A. Efros

Pathological diagnosis relies on the visual inspection of histologically stained thin tissue specimens, where different types of stains are applied to bring contrast to and highlight various desired histological features. However, the…

Medical Physics · Physics 2022-08-18 Xilin Yang , Bijie Bai , Yijie Zhang , Yuzhu Li , Kevin de Haan , Tairan Liu , Aydogan Ozcan

Blind face restoration aims to recover high-quality facial images from various unidentified sources of degradation, posing significant challenges due to the minimal information retrievable from the degraded images. Prior knowledge-based…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Wanglong Lu , Jikai Wang , Tao Wang , Kaihao Zhang , Xianta Jiang , Hanli Zhao

Virtual staining of tissue offers a powerful tool for transforming label-free microscopy images of unstained tissue into equivalents of histochemically stained samples. This study presents a diffusion model-based super-resolution virtual…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Yijie Zhang , Luzhe Huang , Nir Pillar , Yuzhu Li , Hanlong Chen , Aydogan Ozcan

Immunohistochemical (IHC) staining enables precise molecular profiling of protein expression, with over 200 clinically available antibody-based tests in modern pathology. However, comprehensive IHC analysis is frequently limited by…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Fuqiang Chen , Ranran Zhang , Wanming Hu , Deboch Eyob Abera , Yue Peng , Boyun Zheng , Yiwen Sun , Jing Cai , Wenjian Qin

Virtual Try-On technology has garnered significant attention for its potential to transform the online fashion retail experience by allowing users to visualize how garments would look on them without physical trials. While recent advances…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Minh Tran , Johnmark Clements , Annie Prasanna , Tri Nguyen , Ngan Le

Artistic style transfer aims to transfer the learned artistic style onto an arbitrary content image, generating artistic stylized images. Existing generative adversarial network-based methods fail to generate highly realistic stylized…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Zhanjie Zhang , Quanwei Zhang , Huaizhong Lin , Wei Xing , Juncheng Mo , Shuaicheng Huang , Jinheng Xie , Guangyuan Li , Junsheng Luan , Lei Zhao , Dalong Zhang , Lixia Chen

Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Harshal Nishar , Nikhil Chavanke , Nitin Singhal

Stylized text-to-image generation focuses on creating images from textual descriptions while adhering to a style specified by a few reference images. However, subtle style variations within different reference images can hinder the model…

Computer Vision and Pattern Recognition · Computer Science 2024-07-15 Xing Cui , Zekun Li , Pei Pei Li , Huaibo Huang , Xuannan Liu , Zhaofeng He

Histological analysis of tissue samples is one of the most widely used methods for disease diagnosis. After taking a sample from a patient, it goes through a lengthy and laborious preparation, which stains the tissue to visualize different…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Yair Rivenson , Hongda Wang , Zhensong Wei , Yibo Zhang , Harun Gunaydin , Aydogan Ozcan

Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular species in biological tissue with…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Yijie Zhang , Luzhe Huang , Nir Pillar , Yuzhu Li , Lukasz G. Migas , Raf Van de Plas , Jeffrey M. Spraggins , Aydogan Ozcan

Inverting corrupted images into the latent space of diffusion models is challenging. Current methods, which encode an image into a single latent vector, struggle to balance structural fidelity with semantic accuracy, leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Yichen Wu , Xu Liu , Chenxuan Zhao , Xinyu Wu

Modern histopathology relies on the microscopic examination of thin tissue sections stained with histochemical techniques, typically using brightfield or fluorescence microscopy. However, the staining of samples can permanently alter their…

Text-driven diffusion models have significantly advanced the image editing performance by using text prompts as inputs. One crucial step in text-driven image editing is to invert the original image into a latent noise code conditioned on…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Ruibin Li , Ruihuang Li , Song Guo , Lei Zhang

Image inpainting task requires filling the corrupted image with contents coherent with the context. This research field has achieved promising progress by using neural image inpainting methods. Nevertheless, there is still a critical…

Computer Vision and Pattern Recognition · Computer Science 2021-03-23 Lisai Zhang , Qingcai Chen , Baotian Hu , Shuoran Jiang

Text-conditioned image editing has emerged as a powerful tool for editing images. However, in many situations, language can be ambiguous and ineffective in describing specific image edits. When faced with such challenges, visual prompts can…

Computer Vision and Pattern Recognition · Computer Science 2023-07-27 Thao Nguyen , Yuheng Li , Utkarsh Ojha , Yong Jae Lee

Visual Prompt Tuning (VPT) has emerged as a parameter-efficient fine-tuning paradigm for vision transformers, with conventional approaches utilizing dataset-level prompts that remain the same across all input instances. We observe that this…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 Xi Xiao , Yunbei Zhang , Xingjian Li , Tianyang Wang , Xiao Wang , Yuxiang Wei , Jihun Hamm , Min Xu

Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-27 Hanwen Liang , Konstantinos N. Plataniotis , Xingyu Li