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Recent literature on fine-tuning Large Language Models highlights a fundamental debate. While Full Fine-Tuning (FFT) provides the representational plasticity required for high-entropy knowledge injection, Low-Rank Adaptation (LoRA) can…

Large pre-trained language models (PLMs) have shown remarkable performance across various natural language understanding (NLU) tasks, particularly in low-resource settings. Nevertheless, their potential in Automatic Speech Recognition (ASR)…

Finetuning a Large Language Model (LLM) is crucial for generating results towards specific objectives. This research delves into the realm of drug optimization and introduce a novel reinforcement learning algorithm to finetune a drug…

As the parameters of Large Language Models (LLMs) have scaled to hundreds of billions, the demand for efficient training methods -- balancing faster computation and reduced memory usage without sacrificing accuracy -- has become more…

Optimization problems seek to find the best solution to an objective under a set of constraints, and have been widely investigated in real-world applications. Modeling and solving optimization problems in a specific domain typically require…

Large Language Models (LLMs) have significantly advanced natural language processing with exceptional task generalization capabilities. Low-Rank Adaption (LoRA) offers a cost-effective fine-tuning solution, freezing the original model…

Large language model (LLM)-based automatic speech recognition (ASR) achieves strong performance but often incurs high computational costs. This work investigates how to obtain the best LLM-ASR performance efficiently. Through comprehensive…

Studying protein mutations within amino acid sequences holds tremendous significance in life sciences. Protein language models (PLMs) have demonstrated strong capabilities in broad biological applications. However, due to architectural…

Masked language modeling (MLM) plays a key role in pretraining large language models. But the MLM objective is often dominated by high-frequency words that are sub-optimal for learning factual knowledge. In this work, we propose an approach…

Looped language models (LoopLMs) perform iterative latent computation to refine internal representations, offering a promising alternative to explicit chain-of-thought (CoT) reasoning. However, existing reinforcement learning (RL) paradigms…

Reinforcement learning with human feedback for aligning large language models (LLMs) trains a reward model typically using ranking loss with comparison pairs.However, the training procedure suffers from an inherent problem: the uncontrolled…

Aligning large language models (LLMs) with human preferences is essential for safe and useful LLMs. Previous works mainly adopt reinforcement learning (RLHF) and direct preference optimization (DPO) with human feedback for alignment.…

Pretrained models have produced great success in both Computer Vision (CV) and Natural Language Processing (NLP). This progress leads to learning joint representations of vision and language pretraining by feeding visual and linguistic…

The pretrain-transfer paradigm, which underpins the success of large language models (LLMs), has demonstrated the immense power of creating foundation models that learn generalizable representations from vast datasets. However, extending…

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Fine-tuning large language models (LLMs) is crucial for improving their performance on downstream tasks, but full-parameter fine-tuning (Full-FT) is computationally expensive and memory-intensive. Parameter-efficient fine-tuning (PEFT)…

In recent years, there has been a surge in the development of 3D structure-based pre-trained protein models, representing a significant advancement over pre-trained protein language models in various downstream tasks. However, most existing…

Pre-training a language model and then fine-tuning it has shown to be an efficient and effective technique for a wide range of code intelligence tasks, such as code generation, code summarization, and vulnerability detection. However,…

With the development of next generation sequencing techniques, it is fast and cheap to determine protein sequences but relatively slow and expensive to extract useful information from protein sequences because of limitations of traditional…

Large Language Models (LLMs) have showcased remarkable capabilities in following human instructions. However, recent studies have raised concerns about the robustness of LLMs when prompted with instructions combining textual adversarial…