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Diffusion-based methods represented as stochastic differential equations on a continuous-time domain have recently proven successful as a non-adversarial generative model. Training such models relies on denoising score matching, which can…

Machine Learning · Computer Science 2024-11-05 Sarthak Mittal , Korbinian Abstreiter , Stefan Bauer , Bernhard Schölkopf , Arash Mehrjou

Deformable image registration aims to precisely align medical images from different modalities or times. Traditional deep learning methods, while effective, often lack interpretability, real-time observability and adjustment capacity during…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Yongtai Zhuo , Yiqing Shen

Inverse protein folding -- the task of predicting a protein sequence from its backbone atom coordinates -- has surfaced as an important problem in the "top down", de novo design of proteins. Contemporary approaches have cast this problem as…

Diffusion models, while trained for image generation, have emerged as powerful foundational feature extractors for downstream tasks. We find that off-the-shelf diffusion models, trained exclusively to generate natural RGB images, can…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Nurislam Tursynbek , Hastings Greer , Basar Demir , Marc Niethammer

Blind face restoration (BFR) is a highly challenging problem due to the uncertainty of degradation patterns. Current methods have low generalization across photorealistic and heterogeneous domains. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Nan Gao , Jia Li , Huaibo Huang , Zhi Zeng , Ke Shang , Shuwu Zhang , Ran He

Diffusion models have demonstrated their utility as learned priors for solving various inverse problems. However, most existing approaches are limited to linear inverse problems. This paper exploits the efficient and unsupervised posterior…

Image and Video Processing · Electrical Eng. & Systems 2025-01-07 Mehmet Onurcan Kaya , Figen S. Oktem

Diffusion Magnetic Resonance Imaging (dMRI) plays a critical role in studying microstructural changes in the brain. It is, therefore, widely used in clinical practice; yet progress in learning general-purpose representations from dMRI has…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Gustavo Chau Loo Kung , Mohammad Abbasi , Camila Blank , Juze Zhang , Alan Q. Wang , Sophie Ostmeier , Akshay Chaudhari , Kilian Pohl , Ehsan Adeli

Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific…

Quantitative Methods · Quantitative Biology 2019-06-21 Samuel St-Jean , Maxime Chamberland , Max A. Viergever , Alexander Leemans

Diffusion models are a special type of generative model, capable of synthesising new data from a learnt distribution. We introduce DISPR, a diffusion-based model for solving the inverse problem of three-dimensional (3D) cell shape…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Dominik J. E. Waibel , Ernst Röell , Bastian Rieck , Raja Giryes , Carsten Marr

The function of biomolecules such as proteins depends on their ability to interconvert between a wide range of structures or "conformations." Researchers have endeavored for decades to develop computational methods to predict the…

Biomolecules · Quantitative Biology 2026-02-05 Daniel D. Richman , Jessica Karaguesian , Carl-Mikael Suomivuori , Ron O. Dror

Sequences of nucleotides (for DNA and RNA) or amino acids (for proteins) are central objects in biology. Among the most important computational problems is that of sequence alignment, i.e. arranging sequences from different organisms in…

Quantitative Methods · Quantitative Biology 2020-12-08 Anna Paola Muntoni , Andrea Pagnani , Martin Weigt , Francesco Zamponi

Blind face restoration (BFR) is important while challenging. Prior works prefer to exploit GAN-based frameworks to tackle this task due to the balance of quality and efficiency. However, these methods suffer from poor stability and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Xinmin Qiu , Congying Han , Zicheng Zhang , Bonan Li , Tiande Guo , Xuecheng Nie

Recommender systems often grapple with noisy implicit feedback. Most studies alleviate the noise issues from data cleaning perspective such as data resampling and reweighting, but they are constrained by heuristic assumptions. Another…

Information Retrieval · Computer Science 2024-06-18 Jujia Zhao , Wenjie Wang , Yiyan Xu , Teng Sun , Fuli Feng , Tat-Seng Chua

Efficiently identifying accurate correspondences between point clouds is crucial for both rigid and non-rigid point cloud registration. Existing methods usually rely on geometric or semantic feature embeddings to establish correspondences…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Haihua Shi , Qianliang Wu

Discrete diffusion models have demonstrated great promise in modeling various sequence data, ranging from human language to biological sequences. Inspired by the success of RL in language models, there is growing interest in further…

Machine Learning · Computer Science 2026-02-03 Jiaqi Han , Austin Wang , Minkai Xu , Wenda Chu , Meihua Dang , Haotian Ye , Huayu Chen , Yisong Yue , Stefano Ermon

Diffusion models have emerged as the new state-of-the-art generative model with high quality samples, with intriguing properties such as mode coverage and high flexibility. They have also been shown to be effective inverse problem solvers,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Hyungjin Chung , Dohoon Ryu , Michael T. McCann , Marc L. Klasky , Jong Chul Ye

Diffusion models have emerged as powerful generative tools with applications in computer vision and scientific machine learning (SciML), where they have been used to solve large-scale probabilistic inverse problems. Traditionally, these…

In medical imaging, the diffusion models have shown great potential for synthetic image generation tasks. However, these approaches often lack the interpretable connections between the generated and real images and can create anatomically…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Jian-Qing Zheng , Yuanhan Mo , Yang Sun , Jiahua Li , Fuping Wu , Ziyang Wang , Tonia Vincent , Bartłomiej W. Papież

Diffusion model-based approaches recently achieved re-markable success in MRI reconstruction, but integration into clinical routine remains challenging due to its time-consuming convergence. This phenomenon is partic-ularly notable when…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Yu Guan , Qinrong Cai , Wei Li , Qiuyun Fan , Dong Liang , Qiegen Liu

Diffusion-based models have achieved notable empirical successes in reinforcement learning (RL) due to their expressiveness in modeling complex distributions. Despite existing methods being promising, the key challenge of extending existing…

Machine Learning · Computer Science 2024-11-04 Dmitry Shribak , Chen-Xiao Gao , Yitong Li , Chenjun Xiao , Bo Dai