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Inferring dependencies between complex biological traits while accounting for evolutionary relationships between specimens is of great scientific interest yet remains infeasible when trait and specimen counts grow large. The…

To understand biological diversification, it is important to account for large-scale processes that affect the evolutionary history of groups of co-distributed populations of organisms. Such events predict temporally clustered divergences…

Populations and Evolution · Quantitative Biology 2014-08-11 Jamie R. Oaks

Outcome Reporting Bias (ORB) poses significant threats to the validity of meta-analytic findings. It occurs when researchers selectively report outcomes based on the significance or direction of results, potentially leading to distorted…

Methodology · Statistics 2025-07-17 Alessandra Gaia Saracini , Leonhard Held

In this paper, we investigate the parameter estimation for threshold Ornstein$\mathit{-}$Uhlenbeck processes. Least squares method is used to obtain continuous-type and discrete-type estimators for the drift parameters based on continuous…

Statistics Theory · Mathematics 2024-03-28 Yuecai Han , Dingwen Zhang

Matching is one of the most widely used causal inference designs in observational studies, but post-matching confounding bias remains a critical concern. This bias includes overt bias from inexact matching on measured confounders and hidden…

Methodology · Statistics 2026-02-26 Siyu Heng , Yanxin Shen , Pengyun Wang

Large language models (LLMs) are currently aligned using techniques such as reinforcement learning from human feedback (RLHF). However, these methods use scalar rewards that can only reflect user preferences on average. Pluralistic…

Computation and Language · Computer Science 2025-08-13 Jadie Adams , Brian Hu , Emily Veenhuis , David Joy , Bharadwaj Ravichandran , Aaron Bray , Anthony Hoogs , Arslan Basharat

Estimation of reliable whole-brain connectivity is a crucial step towards the use of connectivity information in quantitative approaches to the study of neuropsychiatric disorders. When estimating brain connectivity a challenge is imposed…

Machine Learning · Statistics 2018-05-28 Andrea Insabato , John P. Cunningham , Matthieu Gilson

Subject selection plays a critical role in experimental studies, especially ones with human subjects. Anecdotal evidence suggests that many such studies, done at or near university campus settings suffer from selection bias, i.e., the…

Machine Learning · Computer Science 2020-12-21 Tahereh Arabghalizi , Alexandros Labrinidis

An important problem in evolutionary genomics is to investigate whether a certain trait measured on each sample is associated with the sample phylogenetic tree. The phylogenetic tree represents the shared evolutionary history of the samples…

Populations and Evolution · Quantitative Biology 2024-07-22 Julie Zhang , Gabriel A. Preising , Molly Schumer , Julia A. Palacios

1. Abrupt environmental changes can lead to evolutionary shifts in trait evolution. Identifying these shifts is an important step in understanding the evolutionary history of phenotypes. 2. We propose an ensemble variable selection method…

Populations and Evolution · Quantitative Biology 2022-04-14 Wensha Zhang , Toby Kenney , Lam Si Tung Ho

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterised by an instantaneous rate…

In this paper the problem of retrospective change-point detection and estimation in multivariate linear models is considered. The lower bounds for the error of change-point estimation are proved in different cases (one change-point:…

Statistics Theory · Mathematics 2011-10-27 Boris Brodsky , Boris Darkhovsky

Standard Ornstein-Uhlenbeck (OU) models often yield biased parameter estimates when measurement error is ignored. While the Ornstein-Uhlenbeck State Space Model (OUSSM) addresses this in univariate settings, multidimensional extensions…

Applications · Statistics 2026-05-05 Shanglun Li , Toby Kenney , Hong Gu

The estimation of the extremal dependence structure is spoiled by the impact of the bias, which increases with the number of observations used for the estimation. Already known in the univariate setting, the bias correction procedure is…

Statistics Theory · Mathematics 2015-04-03 Anne-Laure Fougères , Laurens de Haan , Cécile Mercadier

We study asymptotic properties of Bayesian multiple testing procedures and provide sufficient conditions for strong consistency under general dependence structure. We also consider a novel Bayesian multiple testing procedure and associated…

Statistics Theory · Mathematics 2020-05-15 Noirrit K. Chandra , Sourabh Bhattacharya

Comparative biologists are often interested in inferring covariation between multiple biological traits sampled across numerous related taxa. To properly study these relationships, we must control for the shared evolutionary history of the…

The software program BAMM has been widely used to study the dynamics of speciation, extinction, and phenotypic evolution on phylogenetic trees. The program implements a model-based clustering algorithm to identify clades that share common…

Quantitative Methods · Quantitative Biology 2017-11-10 Daniel L Rabosky

Data science projects often involve various machine learning (ML) methods that depend on data, code, and models. One of the key activities in these projects is the selection of a model or algorithm that is appropriate for the data analysis…

Machine Learning · Computer Science 2023-11-27 Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan

A simple way to model phenotypic evolution is to assume that after splitting, the trait values of the sister species diverge as independent Brownian motions. Relying only on a prior distribution for the underlying species tree (conditioned…

Populations and Evolution · Quantitative Biology 2013-05-14 Serik Sagitov , Krzysztof Bartoszek

Many biological characteristics of evolutionary interest are not scalar variables but continuous functions. Given a dataset of function-valued traits generated by evolution, we develop a practical statistical approach to infer ancestral…