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We develop methods for analyzing discrete multivariate longitudinal data and apply them to functional disability data on the U.S. elderly population from the National Long Term Care Survey (NLTCS), 1982-2004. Our models build on a Mixed…

Applications · Statistics 2015-03-05 Daniel Manrique-Vallier

Longitudinal data in electronic health records (EHRs) represent an individual`s clinical history through a sequence of codified concepts, including diagnoses, procedures, medications, and laboratory tests. Generative pre-trained…

Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these…

Machine Learning · Computer Science 2021-05-18 Chang Lu , Chandan K. Reddy , Prithwish Chakraborty , Samantha Kleinberg , Yue Ning

Accurately estimating heterogeneous treatment effects (HTE) in longitudinal settings is essential for personalized decision-making across healthcare, public policy, education, and digital marketing. However, time-varying interventions…

Methodology · Statistics 2025-10-28 Lei Shi , Sizhu Lu , Qiuran Lyu , Peng Ding , Nikos Vlassis

Transformer, originally devised for natural language processing, has also attested significant success in computer vision. Thanks to its super expressive power, researchers are investigating ways to deploy transformers to reinforcement…

Machine Learning · Computer Science 2023-01-24 Shengchao Hu , Li Shen , Ya Zhang , Yixin Chen , Dacheng Tao

In countries that enabled patients to choose their own providers, a common problem is that the patients did not make rational decisions, and hence, fail to use healthcare resources efficiently. This might cause problems such as overwhelming…

Computers and Society · Computer Science 2020-06-25 Lichin Chen , Yu Tsao , Ji-Tian Sheu

Screening and surveillance are routinely used in medicine for early detection of disease and close monitoring of progression. Biomarkers are one of the primarily tools used for these tasks, but their successful translation to clinical…

Emotional states, as indicators of affect, are pivotal to overall health, making their accurate prediction before onset crucial. Current studies are primarily centered on immediate short-term affect detection using data from wearable and…

Deep learning models for medical data are typically trained using task specific objectives that encourage representations to collapse onto a small number of discriminative directions. While effective for individual prediction problems, this…

Machine Learning · Computer Science 2026-02-10 Yuanyun Zhang , Mingxuan Zhang , Siyuan Li , Zihan Wang , Haoran Chen , Wenbo Zhou , Shi Li

Large-scale pre-trained models (PTMs) such as BERT and GPT have recently achieved great success in Natural Language Processing and Computer Vision domains. However, the development of PTMs on healthcare time-series data is lagging…

Machine Learning · Computer Science 2024-09-10 Ziyang Song , Qincheng Lu , Hao Xu , He Zhu , David L. Buckeridge , Yue Li

Deep learning models have shown a great effectiveness in recognition of findings in medical images. However, they cannot handle the ever-changing clinical environment, bringing newly annotated medical data from different sources. To exploit…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Mohammad Mahdi Derakhshani , Ivona Najdenkoska , Tom van Sonsbeek , Xiantong Zhen , Dwarikanath Mahapatra , Marcel Worring , Cees G. M. Snoek

We propose to meta-learn an a self-supervised patient trajectory forecast learning rule by meta-training on a meta-objective that directly optimizes the utility of the patient representation over the subsequent clinical outcome prediction.…

Machine Learning · Computer Science 2024-07-30 Yuan Xue , Nan Du , Anne Mottram , Martin Seneviratne , Andrew M. Dai

Estimating the effect of a treatment on a given outcome, conditioned on a vector of covariates, is central in many applications. However, learning the impact of a treatment on a continuous temporal response, when the covariates suffer…

Machine Learning · Computer Science 2019-06-11 Guangyi Zhang , Reza Ashrafi , Anne Juuti , Kirsi Pietiläinen , Pekka Marttinen

Analyzing electronic health records (EHR) poses significant challenges because often few samples are available describing a patient's health and, when available, their information content is highly diverse. The problem we consider is how to…

Machine Learning · Statistics 2019-12-20 Alexis Bellot , Mihaela van der Schaar

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that…

Machine Learning · Computer Science 2020-05-08 Anirudh Som , Narayanan Krishnamurthi , Matthew Buman , Pavan Turaga

Many applications of machine learning methods involve an iterative protocol in which data are collected, a model is trained, and then outputs of that model are used to choose what data to consider next. For example, one data-driven approach…

Machine Learning · Computer Science 2025-04-07 Clara Fannjiang , Stephen Bates , Anastasios N. Angelopoulos , Jennifer Listgarten , Michael I. Jordan

Model-based approaches for image reconstruction, analysis and interpretation have made significant progress over the last decades. Many of these approaches are based on either mathematical, physical or biological models. A challenge for…

Computer Vision and Pattern Recognition · Computer Science 2019-10-01 Daniel Rueckert , Julia A. Schnabel

Traditional model-based diagnosis relies on constructing explicit system models, a process that can be laborious and expertise-demanding. In this paper, we propose a novel framework that combines concepts of model-based diagnosis with deep…

Artificial Intelligence · Computer Science 2023-10-11 Jan Lukas Augustin , Oliver Niggemann

Transformers have demonstrated impressive strength in long-term series forecasting. Existing prediction research mostly focused on mapping past short sub-series (lookback window) to future series (forecast window). The longer training…

Machine Learning · Computer Science 2023-02-22 Julong Young , Junhui Chen , Feihu Huang , Jian Peng

Reinforcement learning (RL) has the potential to significantly improve clinical decision making. However, treatment policies learned via RL from observational data are sensitive to subtle choices in study design. We highlight a simple…

Machine Learning · Computer Science 2020-12-23 Christina X. Ji , Michael Oberst , Sanjat Kanjilal , David Sontag
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