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Understanding protein solubility is essential for their functional applications. Computational methods for predicting protein solubility are crucial for reducing experimental costs and enhancing the efficiency and success rates of protein…

Quantitative Methods · Quantitative Biology 2024-07-01 Yang Tan , Jia Zheng , Liang Hong , Bingxin Zhou

Automatic protein function prediction (AFP) is classified as a large-scale multi-label classification problem aimed at automating protein enrichment analysis to eliminate the current reliance on labor-intensive wet-lab methods. Currently,…

Quantitative Methods · Quantitative Biology 2023-07-26 Zihao Li , Changkun Jiang , Jianqiang Li

Molecular subtyping of breast cancer is crucial for personalized treatment and prognosis. Traditional classification approaches rely on either histopathological images or gene expression profiling, limiting their predictive power. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Amin Honarmandi Shandiz

Spatial Transcriptomics (ST) merges the benefits of pathology images and gene expression, linking molecular profiles with tissue structure to analyze spot-level function comprehensively. Predicting gene expression from histology images is a…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Chen Zhang , Yilu An , Ying Chen , Hao Li , Xitong Ling , Lihao Liu , Junjun He , Yuxiang Lin , Zihui Wang , Rongshan Yu

This study focuses on the problem of path modeling in heterogeneous information networks and proposes a multi-hop path-aware recommendation framework. The method centers on multi-hop paths composed of various types of entities and…

Information Retrieval · Computer Science 2025-05-12 Hongye Zheng , Yue Xing , Lipeng Zhu , Xu Han , Junliang Du , Wanyu Cui

Low-dose positron emission tomography (PET) image reconstruction methods have potential to significantly improve PET as an imaging modality. Deep learning provides a promising means of incorporating prior information into the image…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Cameron Dennis Pain , Yasmeen George , Alex Fornito , Gary Egan , Zhaolin Chen

Deeply-learned planning methods are often based on learning representations that are optimized for unrelated tasks. For example, they might be trained on reconstructing the environment. These representations are then combined with predictor…

Machine Learning · Computer Science 2021-03-18 Hlynur Davíð Hlynsson , Merlin Schüler , Robin Schiewer , Tobias Glasmachers , Laurenz Wiskott

The task of hyper-parameter optimization (HPO) is burdened with heavy computational costs due to the intractability of optimizing both a model's weights and its hyper-parameters simultaneously. In this work, we introduce a new class of HPO…

Machine Learning · Computer Science 2021-12-14 Mathieu Tuli , Mahdi S. Hosseini , Konstantinos N. Plataniotis

The ability to quickly learn new knowledge (e.g. new classes or data distributions) is a big step towards human-level intelligence. In this paper, we consider scenarios that require learning new classes or data distributions quickly and…

Machine Learning · Computer Science 2021-09-13 Fei Mi , Tao Lin , Boi Faltings

Multi-modal learning is a fast growing area in artificial intelligence. It tries to help machines understand complex things by combining information from different sources, like images, text, and audio. By using the strengths of each…

Machine Learning · Computer Science 2025-12-22 Qihang Jin , Enze Ge , Yuhang Xie , Hongying Luo , Junhao Song , Ziqian Bi , Chia Xin Liang , Jibin Guan , Joe Yeong , Xinyuan Song , Junfeng Hao

Classical models for supervised machine learning, such as decision trees, are efficient and interpretable predictors, but their quality is highly dependent on the particular choice of input features. Although neural networks can learn…

Machine Learning · Computer Science 2025-10-17 Gabriel Poesia , Georgia Gabriela Sampaio

Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions.…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Mingxin Liu , Chengfei Cai , Jun Li , Pengbo Xu , Jinze Li , Jiquan Ma , Jun Xu

Multimodal emotion recognition (MER) in practical scenarios is significantly challenged by the presence of missing or incomplete data across different modalities. To overcome these challenges, researchers have aimed to simulate incomplete…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Qi Fan , Haolin Zuo , Rui Liu , Zheng Lian , Guanglai Gao

Emotions play a central role in the social life of every human being, and their study, which represents a multidisciplinary subject, embraces a great variety of research fields. Especially concerning the latter, the analysis of facial…

Computer Vision and Pattern Recognition · Computer Science 2021-05-07 Fabio Valerio Massoli , Donato Cafarelli , Claudio Gennaro , Giuseppe Amato , Fabrizio Falchi

Recent advancements in machine learning (ML) are transforming the field of structural biology. For example, AlphaFold, a groundbreaking neural network for protein structure prediction, has been widely adopted by researchers. The…

Multimodal learning seeks to combine data from multiple input sources to enhance the performance of different downstream tasks. In real-world scenarios, performance can degrade substantially if some input modalities are missing. Existing…

Machine Learning · Computer Science 2024-10-10 Niki Nezakati , Md Kaykobad Reza , Ameya Patil , Mashhour Solh , M. Salman Asif

Cross-platform verification, a critical undertaking in the realm of early-stage quantum computing, endeavors to characterize the similarity of two imperfect quantum devices executing identical algorithms, utilizing minimal measurements.…

Quantum Physics · Physics 2023-11-08 Yang Qian , Yuxuan Du , Zhenliang He , Min-hsiu Hsieh , Dacheng Tao

Accurate identification of bioactive peptides (BPs) and protein post-translational modifications (PTMs) is essential for understanding protein function and advancing therapeutic discovery. However, most computational methods remain limited…

Machine Learning · Computer Science 2025-12-05 Jixiu Zhai , Zikun Wang , Chupei Tang , Haitian Zhong , Ziyang Xu , Yuhuan Liu , Shengrui Xu , Jingwan Wang , Dan Huang , Tianchi Lu

Learning from human feedback has enabled the alignment of language models (LMs) with human preferences. However, collecting human preferences is expensive and time-consuming, with highly variable annotation quality. An appealing alternative…

Representation learning on networks aims to derive a meaningful vector representation for each node, thereby facilitating downstream tasks such as link prediction, node classification, and node clustering. In heterogeneous text-rich…

Computation and Language · Computer Science 2023-06-06 Bowen Jin , Yu Zhang , Qi Zhu , Jiawei Han