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Missing data imputation is an important research topic in data mining. Large-scale Molecular descriptor data may contains missing values (MVs). However, some methods for downstream analyses, including some prediction tools, require a…

Computational Engineering, Finance, and Science · Computer Science 2013-12-13 Doreswamy , Chanabasayya . M. Vastrad

Large language models (LLMs) hold considerable potential for advancing scientific discovery, yet systematic assessment of their dynamic reasoning in real-world research remains limited. Current scientific evaluation benchmarks predominantly…

Computation and Language · Computer Science 2026-03-27 Taolin Han , Shuang Wu , Jinghang Wang , Yuhao Zhou , Renquan Lv , Bing Zhao , Wei Hu

The emergence of agent-based systems represents a significant advancement in artificial intelligence, with growing applications in automated data extraction. However, chemical information extraction remains a formidable challenge due to the…

Patent drafting presents significant challenges due to its reliance on the extensive experience and specialized expertise of patent attorneys, who must possess both legal acumen and technical understanding of an invention to craft patent…

Machine Learning · Computer Science 2025-10-14 Sai Krishna Reddy Mudhiganti , Juanyan Wang , Ruo Yang , Manali Sharma

Precise recognition, editing, and generation of molecules are essential prerequisites for both chemists and AI systems tackling various chemical tasks. We present MolLangBench, a comprehensive benchmark designed to evaluate fundamental…

Computation and Language · Computer Science 2026-03-24 Feiyang Cai , Jiahui Bai , Tao Tang , Guijuan He , Joshua Luo , Tianyu Zhu , Srikanth Pilla , Gang Li , Ling Liu , Feng Luo

The efficient exploration of chemical space to design molecules with intended properties enables the accelerated discovery of drugs, materials, and catalysts, and is one of the most important outstanding challenges in chemistry. Encouraged…

Computational Engineering, Finance, and Science · Computer Science 2023-10-12 AkshatKumar Nigam , Robert Pollice , Gary Tom , Kjell Jorner , John Willes , Luca A. Thiede , Anshul Kundaje , Alan Aspuru-Guzik

Strategic decisions rely heavily on non-scientific instrumentation to forecast emerging technologies and leading companies. Instead, we build a fast quantitative system with a small computational footprint to discover the most important…

Cryptography and Security · Computer Science 2022-09-25 Michael Tsesmelis , Ljiljana Dolamic , Marcus Matthias Keupp , Dimitri Percia David , Alain Mermoud

The design of alloys is a multi-scale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process…

Artificial Intelligence · Computer Science 2024-07-16 Alireza Ghafarollahi , Markus J. Buehler

This paper examines how pharmaceutical Artificial Intelligence advancements may affect the development of new drugs in the coming years. The question was answered by reviewing a rich body of source material, including industry literature,…

Computers and Society · Computer Science 2021-07-09 Adam Zielinski

The discovery of new materials has been the essential force which brings a discontinuous improvement to industrial products' performance. However, the extra-vast combinatorial design space of material structures exceeds human experts'…

Drug discovery aims to find novel compounds with specified chemical property profiles. In terms of generative modeling, the goal is to learn to sample molecules in the intersection of multiple property constraints. This task becomes…

Machine Learning · Computer Science 2020-07-06 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Assessing the novelty of patent claims is a critical yet challenging task traditionally performed by patent examiners. While advancements in NLP have enabled progress in various patent-related tasks, novelty assessment remains unexplored.…

Computation and Language · Computer Science 2025-02-11 Hayato Ikoma , Teruko Mitamura

Software systems typically consist of various interacting components and units. While these components can be tested and shown to work correctly in isolation, when integrated and start interacting with each other, they may fail to produce…

Software Engineering · Computer Science 2018-12-07 Mehrdad Saadatmand

Process mining offers techniques to exploit event data by providing insights and recommendations to improve business processes. The growing amount of algorithms for process discovery has raised the question of which algorithms perform best…

Software Engineering · Computer Science 2018-06-20 Toon Jouck , Alfredo Bolt , Benoît Depaire , Massimiliano de Leoni , Wil M. P. van der Aalst

Discovering explicit physical laws has traditionally depended on human intuition and domain expertise. Recent advances in artificial intelligence, particularly large language models (LLMs), offer a new route to accelerate this process by…

Materials Science · Physics 2026-01-30 Bo Hu , Siyu Liu , Beilin Ye , Yun Hao , Yanhui Liu , Yang Lu , Ju Li , David J. Srolovitz , Tongqi Wen

The study by Jung et al. (Jung H, Covino R, Arjun A, et al., Nat Comput Sci. 3:334-345 (2023)) introduced Artificial Intelligence for Molecular Mechanism Discovery (AIMMD), a novel sampling algorithm that integrates machine learning to…

Computational Physics · Physics 2026-02-06 Porhouy Minh , Sapna Sarupria

The success of drug discovery and development relies on the precise prediction of molecular activities and properties. While in silico molecular property prediction has shown remarkable potential, its use has been limited so far to assays…

Biomolecules · Quantitative Biology 2024-09-04 Maximilian G. Schuh , Davide Boldini , Stephan A. Sieber

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Fatemeh Ghezloo , Mehmet Saygin Seyfioglu , Rustin Soraki , Wisdom O. Ikezogwo , Beibin Li , Tejoram Vivekanandan , Joann G. Elmore , Ranjay Krishna , Linda Shapiro

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an…

We present a perspective on molecular machine learning (ML) in the field of chemical process engineering. Recently, molecular ML has demonstrated great potential in (i) providing highly accurate predictions for properties of pure components…

Chemical Physics · Physics 2025-09-01 Jan G. Rittig , Manuel Dahmen , Martin Grohe , Philippe Schwaller , Alexander Mitsos