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We present a novel diffusion-based approach to generate synthetic histopathological Whole Slide Images (WSIs) at an unprecedented gigapixel scale. Synthetic WSIs have many potential applications: They can augment training datasets to…
Combining neuroimaging datasets from multiple sites and scanners can help increase statistical power and thus provide greater insight into subtle neuroanatomical effects. However, site-specific effects pose a challenge by potentially…
Generative models are used as an alternative data augmentation technique to alleviate the data scarcity problem faced in the medical imaging field. Diffusion models have gathered special attention due to their innovative generation…
Latent diffusion models excel at generating high-quality images but lose the benefits of end-to-end modeling. They discard information during image encoding, require a separately trained decoder, and model an auxiliary distribution to the…
The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…
Diffusion models, which can be viewed as a special case of hierarchical variational autoencoders (HVAEs), have shown profound success in generating photo-realistic images. In contrast, standard HVAEs often produce images of inferior quality…
Medical image segmentation models struggle with rare abnormalities due to scarce annotated pathological data. We propose DiffAug a novel framework that combines textguided diffusion-based generation with automatic segmentation validation to…
In settings requiring synthetic data generation based on a clinical cohort, e.g., due to data protection regulations, heterogeneity across individuals might be a nuisance that we need to control or faithfully preserve. The sources of such…
Low-field to high-field MRI synthesis has emerged as a cost-effective strategy to enhance image quality under hardware and acquisition constraints, particularly in scenarios where access to high-field scanners is limited or impractical.…
Artificial Intelligence in healthcare is a new and exciting frontier and the possibilities are endless. With deep learning approaches beating human performances in many areas, the logical next step is to attempt their application in the…
Diffusion models create data from noise by inverting the forward paths of data towards noise and have emerged as a powerful generative modeling technique for high-dimensional, perceptual data such as images and videos. Rectified flow is a…
Despite the increasing use of deep learning in medical image segmentation, acquiring sufficient training data remains a challenge in the medical field. In response, data augmentation techniques have been proposed; however, the generation of…
Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…
In the realm of image synthesis, achieving fidelity to a reference image while adhering to conditional prompts remains a significant challenge. This paper proposes a novel approach that integrates a diffusion model with latent space…
Diffusion models for text-to-image generation, known for their efficiency, accessibility, and quality, have gained popularity. While inference with these systems on consumer-grade GPUs is increasingly feasible, training from scratch…
We investigate the utility of diffusion generative models to efficiently synthesise datasets that effectively train deep learning models for image analysis. Specifically, we propose novel $\Gamma$-distribution Latent Denoising Diffusion…
Latent diffusion models (LDMs) power state-of-the-art high-resolution generative image models. LDMs learn the data distribution in the latent space of an autoencoder (AE) and produce images by mapping the generated latents into RGB image…
Variational auto-encoders (VAEs) provide an attractive solution to image generation problem. However, they tend to produce blurred and over-smoothed images due to their dependence on pixel-wise reconstruction loss. This paper introduces a…
Computer-aided tumor detection has shown great potential in enhancing the interpretation of over 80 million CT scans performed annually in the United States. However, challenges arise due to the rarity of CT scans with tumors, especially…
Large annotated datasets are required for training deep learning models, but in medical imaging data sharing is often complicated due to ethics, anonymization and data protection legislation. Generative AI models, such as generative…