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We present fast, realistic image generation on high-resolution, multimodal datasets using hierarchical variational autoencoders (VAEs) trained on a deterministic autoencoder's latent space. In this two-stage setup, the autoencoder…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Troy Luhman , Eric Luhman

By decomposing the image formation process into a sequential application of denoising autoencoders, diffusion models (DMs) achieve state-of-the-art synthesis results on image data and beyond. Additionally, their formulation allows for a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Robin Rombach , Andreas Blattmann , Dominik Lorenz , Patrick Esser , Björn Ommer

Artificial Intelligence (AI) based image analysis has an immense potential to support diagnostic histopathology, including cancer diagnostics. However, developing supervised AI methods requires large-scale annotated datasets. A potentially…

Synthetic data generation in histopathology faces unique challenges: preserving tissue heterogeneity, capturing subtle morphological features, and scaling to unannotated datasets. We present a latent diffusion model that generates realistic…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Saghir Alfasly , Wataru Uegami , MD Enamul Hoq , Ghazal Alabtah , H. R. Tizhoosh

Accurate and robust medical image classification is a challenging task, especially in application domains where available annotated datasets are small and present high imbalance between target classes. Considering that data acquisition is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Neil De La Fuente , Mireia Majó , Irina Luzko , Henry Córdova , Gloria Fernández-Esparrach , Jorge Bernal

Latent generative models have shown remarkable progress in high-fidelity image synthesis, typically using a two-stage training process that involves compressing images into latent embeddings via learned tokenizers in the first stage. The…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Tejaswini Medi , Hsien-Yi Wang , Arianna Rampini , Margret Keuper

Diffusion models have attained impressive visual quality for image synthesis. However, how to interpret and manipulate the latent space of diffusion models has not been extensively explored. Prior work diffusion autoencoders encode the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-26 Zeyu Lu , Chengyue Wu , Xinyuan Chen , Yaohui Wang , Lei Bai , Yu Qiao , Xihui Liu

Generative AI has received substantial attention in recent years due to its ability to synthesize data that closely resembles the original data source. While Generative Adversarial Networks (GANs) have provided innovative approaches for…

Computer Vision and Pattern Recognition · Computer Science 2023-04-04 Xuan Xu , Saarthak Kapse , Rajarsi Gupta , Prateek Prasanna

Recent advances in synthetic imaging open up opportunities for obtaining additional data in the field of surgical imaging. This data can provide reliable supplements supporting surgical applications and decision-making through computer…

Image and Video Processing · Electrical Eng. & Systems 2023-12-07 Simeon Allmendinger , Patrick Hemmer , Moritz Queisner , Igor Sauer , Leopold Müller , Johannes Jakubik , Michael Vössing , Niklas Kühl

Deep learning based medical image recognition systems often require a substantial amount of training data with expert annotations, which can be expensive and time-consuming to obtain. Recently, synthetic augmentation techniques have been…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Jiarong Ye , Haomiao Ni , Peng Jin , Sharon X. Huang , Yuan Xue

While hundreds of artificial intelligence (AI) algorithms are now approved or cleared by the US Food and Drugs Administration (FDA), many studies have shown inconsistent generalization or latent bias, particularly for underrepresented…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Luke W. Sagers , James A. Diao , Luke Melas-Kyriazi , Matthew Groh , Pranav Rajpurkar , Adewole S. Adamson , Veronica Rotemberg , Roxana Daneshjou , Arjun K. Manrai

Histopathology image classification is crucial for the accurate identification and diagnosis of various diseases but requires large and diverse datasets. Obtaining such datasets, however, is often costly and time-consuming due to the need…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Leire Benito-Del-Valle , Aitor Alvarez-Gila , Itziar Eguskiza , Cristina L. Saratxaga

Generative learning models in medical research are crucial in developing training data for deep learning models and advancing diagnostic tools, but the problem of high-quality, diverse images is an open topic of research. Quantum-enhanced…

Quantum Physics · Physics 2025-08-14 Kübra Yeter-Aydeniz , Nora M. Bauer , Pranay Jain , Max Masnick

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…

Image and Video Processing · Electrical Eng. & Systems 2021-04-14 Adalberto Claudio Quiros , Roderick Murray-Smith , Ke Yuan

Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions…

Image and Video Processing · Electrical Eng. & Systems 2024-12-24 Abdullah al Nomaan Nafi , Md. Alamgir Hossain , Rakib Hossain Rifat , Md Mahabub Uz Zaman , Md Manjurul Ahsan , Shivakumar Raman

The development of robust artificial intelligence models for histopathology diagnosis is severely constrained by the scarcity of expert-annotated lesion data, particularly for rare pathologies and underrepresented disease subtypes. While…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Mohamad Koohi-Moghadam , Mohammad-Ali Nikouei Mahani , Kyongtae Tyler Bae

Latent diffusion models have established a new state-of-the-art in high-resolution visual generation. Integrating Vision Foundation Model priors improves generative efficiency, yet existing latent designs remain largely heuristic. These…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Hangyu Liu , Jianyong Wang , Yutao Sun

The recent use of diffusion prior, enhanced by pre-trained text-image models, has markedly elevated the performance of image super-resolution (SR). To alleviate the huge computational cost required by pixel-based diffusion SR, latent-based…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Feng Luo , Jinxi Xiang , Jun Zhang , Xiao Han , Wei Yang

Latent diffusion models have emerged as the leading approach for generating high-quality images and videos, utilizing compressed latent representations to reduce the computational burden of the diffusion process. While recent advancements…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Ivan Skorokhodov , Sharath Girish , Benran Hu , Willi Menapace , Yanyu Li , Rameen Abdal , Sergey Tulyakov , Aliaksandr Siarohin

This paper introduces an innovative methodology for producing high-quality 3D lung CT images guided by textual information. While diffusion-based generative models are increasingly used in medical imaging, current state-of-the-art…

Image and Video Processing · Electrical Eng. & Systems 2024-10-16 Yanwu Xu , Li Sun , Wei Peng , Shuyue Jia , Katelyn Morrison , Adam Perer , Afrooz Zandifar , Shyam Visweswaran , Motahhare Eslami , Kayhan Batmanghelich
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