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Related papers: Are Clinical T5 Models Better for Clinical Text?

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Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Recent advances in LLMs have greatly improved general-domain NLP tasks. Yet, their adoption in critical domains, such as clinical trial recruitment, remains limited. As trials are designed in natural language and patient data is represented…

Computation and Language · Computer Science 2026-01-01 Shrestha Ghosh , Moritz Schneider , Carina Reinicke , Carsten Eickhoff

Pre-trained encoder-decoder transformer architectures have become increasingly popular recently with the advent of T5 models. T5 has also become more favorable over other architectures like BERT due to the amount of data that it is…

Computation and Language · Computer Science 2022-10-25 Frederick Liu , Terry Huang , Shihang Lyu , Siamak Shakeri , Hongkun Yu , Jing Li

While Large Language Models (LLMs) excel in world knowledge understanding, adapting them to specific subfields requires precise adjustments. Due to the model's vast scale, traditional global fine-tuning methods for large models can be…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Jiawei Chen , Yue Jiang , Dingkang Yang , Mingcheng Li , Jinjie Wei , Ziyun Qian , Lihua Zhang

Inevitable domain and task discrepancies in real-world scenarios can impair the generalization performance of the pre-trained deep models for medical data. Therefore, we audaciously propose that we should build a general-purpose medical AI…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Huahui Yi , Ziyuan Qin , Qicheng Lao , Wei Xu , Zekun Jiang , Dequan Wang , Shaoting Zhang , Kang Li

Large Language Models (LLMs) have been widely applied in various professional fields. By fine-tuning the models using domain specific question and answer datasets, the professional domain knowledge and Q\&A abilities of these models have…

Computation and Language · Computer Science 2024-07-17 Qimin Yang , Rongsheng Wang , Jiexin Chen , Runqi Su , Tao Tan

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

The application of large language models (LLMs) in healthcare has gained significant attention due to their ability to process complex medical data and provide insights for clinical decision-making. These models have demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Amna Khalid , Ayma Khalid , Umar Khalid

Large Language Models (LLMs) fine-tuned for specific domains exhibit strong performance; however, the underlying mechanisms by which this fine-tuning reshapes their parametric space are not well understood. Prior works primarily focus on…

Computation and Language · Computer Science 2025-10-13 Eshaan Tanwar , Deepak Nathani , William Yang Wang , Tanmoy Chakraborty

Background: Large Language Models (LLMs) are transforming artificial intelligence applications in healthcare due to their ability to understand, generate, and summarize complex medical text. They offer valuable support to clinicians,…

Computation and Language · Computer Science 2026-04-14 Subin Santhosh , Farwa Abbas , Hussain Ahmad , Claudia Szabo

Large language models (LLMs) have been applied to tasks in healthcare, ranging from medical exam questions to responding to patient questions. With increasing institutional partnerships between companies producing LLMs and healthcare…

Computation and Language · Computer Science 2024-04-10 Jesutofunmi A. Omiye , Haiwen Gui , Shawheen J. Rezaei , James Zou , Roxana Daneshjou

Large Language Models (LLMs) are continuously being applied in a more diverse set of contexts. At their current state, however, even state-of-the-art LLMs such as Generative Pre-Trained Transformer 4 (GTP-4) have challenges when extracting…

Computation and Language · Computer Science 2024-06-05 Felipe A. Rodriguez Y.

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

Large language models (LLMs) have demonstrated strong performance in general-purpose machine translation, but their effectiveness in complex, domain-sensitive translation tasks remains underexplored. Recent advancements in Large Reasoning…

Computation and Language · Computer Science 2025-05-27 Yongshi Ye , Biao Fu , Chongxuan Huang , Yidong Chen , Xiaodong Shi

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Large language models (LLMs) have demonstrated remarkable capabilities, but they require vast amounts of data and computational resources. In contrast, smaller models (SMs), while less powerful, can be more efficient and tailored to…

Test-time scaling has recently emerged as a promising approach for enhancing the reasoning capabilities of large language models or vision-language models during inference. Although a variety of test-time scaling strategies have been…

Computation and Language · Computer Science 2025-06-17 Gyutaek Oh , Seoyeon Kim , Sangjoon Park , Byung-Hoon Kim

There are many cases where LLMs are used for specific tasks in a single domain. These usually require less general, but more domain-specific knowledge. Highly capable, general-purpose state-of-the-art language models like GPT-4 or…

Machine Learning · Computer Science 2024-07-30 Tobias Kerner

Since the inception of the Transformer architecture in 2017, Large Language Models (LLMs) such as GPT and BERT have evolved significantly, impacting various industries with their advanced capabilities in language understanding and…

Computation and Language · Computer Science 2024-05-30 Yining Huang , Keke Tang , Meilian Chen , Boyuan Wang