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Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…

Biomolecules · Quantitative Biology 2025-03-14 Jiarui Lu , Xiaoyin Chen , Stephen Zhewen Lu , Chence Shi , Hongyu Guo , Yoshua Bengio , Jian Tang

This thesis focuses on improving the pre-training of natural language models using unsupervised raw data to make them more efficient and aligned with downstream applications. In the first part, we introduce three alternative pre-training…

Computation and Language · Computer Science 2023-09-18 Luca Di Liello

Large Language Models (LLMs) have achieved remarkable success, yet recent findings reveal that their deeper layers often contribute minimally and can be pruned without affecting overall performance. While some view this as an opportunity…

Machine Learning · Computer Science 2025-08-05 Pengxiang Li , Lu Yin , Shiwei Liu

Modern neural language models (LMs) are powerful tools for modeling human sentence production and comprehension, and their internal representations are remarkably well-aligned with representations of language in the human brain. But to…

Computation and Language · Computer Science 2024-03-27 Chengxu Zhuang , Evelina Fedorenko , Jacob Andreas

We introduce Medal S, a medical segmentation foundation model that supports native-resolution spatial and textual prompts within an end-to-end trainable framework. Unlike text-only methods lacking spatial awareness, Medal S achieves…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Pengcheng Shi , Jiawei Chen , Jiaqi Liu , Xinglin Zhang , Tao Chen , Lei Li

Knowledge of mixtures' phase equilibria is crucial in nature and technical chemistry. Phase equilibria calculations of mixtures require activity coefficients. However, experimental data on activity coefficients is often limited due to high…

Chemical Physics · Physics 2023-09-22 Benedikt Winter , Clemens Winter , Johannes Schilling , André Bardow

Endowing Large Multimodal Models (LMMs) with visual grounding capability can significantly enhance AIs' understanding of the visual world and their interaction with humans. However, existing methods typically fine-tune the parameters of…

Computer Vision and Pattern Recognition · Computer Science 2025-04-14 Size Wu , Sheng Jin , Wenwei Zhang , Lumin Xu , Wentao Liu , Wei Li , Chen Change Loy

Neural language models (LMs) are typically trained using only lexical features, such as surface forms of words. In this paper, we argue this deprives the LM of crucial syntactic signals that can be detected at high confidence using existing…

Computation and Language · Computer Science 2018-03-13 Duncan Blythe , Alan Akbik , Roland Vollgraf

Semantic face editing has achieved substantial progress in recent years. Known as a growingly popular method, latent space manipulation performs face editing by changing the latent code of an input face to liberate users from painting…

Computer Vision and Pattern Recognition · Computer Science 2022-03-28 Wenjing Huang , Shikui Tu , Lei Xu

Large Language Models store extensive factual knowledge acquired during large-scale pre-training. However, this knowledge is inherently static, reflecting only the state of the world at the time of training. Knowledge editing has emerged as…

Computation and Language · Computer Science 2025-10-14 Geunyeong Jeong , Juoh Sun , Seonghee Lee , Harksoo Kim

We introduce Sentence-level Language Modeling, a new pre-training objective for learning a discourse language representation in a fully self-supervised manner. Recent pre-training methods in NLP focus on learning either bottom or top-level…

Computation and Language · Computer Science 2020-11-02 Haejun Lee , Drew A. Hudson , Kangwook Lee , Christopher D. Manning

Knowledge editing aims to change language models' performance on several special cases (i.e., editing scope) by infusing the corresponding expected knowledge into them. With the recent advancements in large language models (LLMs), knowledge…

Computation and Language · Computer Science 2024-05-31 Jiaan Wang , Yunlong Liang , Zengkui Sun , Yuxuan Cao , Jiarong Xu , Fandong Meng

Unsupervised methods are promising for abstractive text summarization in that the parallel corpora is not required. However, their performance is still far from being satisfied, therefore research on promising solutions is on-going. In this…

Computation and Language · Computer Science 2020-10-12 Ryosuke Kohita , Akifumi Wachi , Yang Zhao , Ryuki Tachibana

Semantic identifier (ID) is an important concept in information retrieval that aims to preserve the semantics of objects such as documents and items inside their IDs. Previous studies typically adopt a two-stage pipeline to learn semantic…

Information Retrieval · Computer Science 2024-06-14 Bowen Jin , Hansi Zeng , Guoyin Wang , Xiusi Chen , Tianxin Wei , Ruirui Li , Zhengyang Wang , Zheng Li , Yang Li , Hanqing Lu , Suhang Wang , Jiawei Han , Xianfeng Tang

Language Models (LMs) struggle with linguistic understanding at the discourse level, even though discourse patterns such as coherence, cohesion, and narrative flow are prevalent in their pre-training data. To improve the discourse…

Computation and Language · Computer Science 2026-02-17 Zachary Bamberger , Ofek Glick , Chaim Baskin , Yonatan Belinkov

Lifelong learning enables large language models (LLMs) to adapt to evolving information by continually updating their internal knowledge. An ideal system should support efficient, wide-ranging updates while preserving existing capabilities…

Computation and Language · Computer Science 2026-03-11 Xiaojie Gu , Ziying Huang , Jia-Chen Gu , Kai Zhang

Neural implicit representations of 3D shapes have shown great potential in 3D shape editing due to their ability to model high-level semantics and continuous geometric representations. However, existing methods often suffer from limited…

Graphics · Computer Science 2025-12-05 Jin Zhou , Hongliang Yang , Pengfei Xu , Hui Huang

Small Language Models (SLMs) have gained substantial attention due to their ability to execute diverse language tasks successfully while using fewer computer resources. These models are particularly ideal for deployment in limited…

Computation and Language · Computer Science 2025-05-30 Tanjil Hasan Sakib , Md. Tanzib Hosain , Md. Kishor Morol

We propose Seq2Edits, an open-vocabulary approach to sequence editing for natural language processing (NLP) tasks with a high degree of overlap between input and output texts. In this approach, each sequence-to-sequence transduction is…

Computation and Language · Computer Science 2020-09-24 Felix Stahlberg , Shankar Kumar

We introduce MIM (Masked Image Modeling)-Refiner, a contrastive learning boost for pre-trained MIM models. MIM-Refiner is motivated by the insight that strong representations within MIM models generally reside in intermediate layers.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Benedikt Alkin , Lukas Miklautz , Sepp Hochreiter , Johannes Brandstetter