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Vision-threatening eye diseases pose a major global health burden, with timely diagnosis limited by workforce shortages and restricted access to specialized care. While multimodal large language models (MLLMs) show promise for medical image…

This paper proposes one of the first clinical applications of multimodal large language models (LLMs) as an assistant for radiologists to check errors in their reports. We created an evaluation dataset from real-world radiology datasets…

Computation and Language · Computer Science 2024-03-05 Jinge Wu , Yunsoo Kim , Eva C. Keller , Jamie Chow , Adam P. Levine , Nikolas Pontikos , Zina Ibrahim , Paul Taylor , Michelle C. Williams , Honghan Wu

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Medical patient data is always multimodal. Images, text, age, gender, histopathological data are only few examples for different modalities in this context. Processing and integrating this multimodal data with deep learning based methods is…

Artificial Intelligence · Computer Science 2025-09-11 Christian Gapp , Elias Tappeiner , Martin Welk , Rainer Schubert

Medical image analysis is essential to clinical diagnosis and treatment, which is increasingly supported by multi-modal large language models (MLLMs). However, previous research has primarily focused on 2D medical images, leaving 3D images…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Fan Bai , Yuxin Du , Tiejun Huang , Max Q. -H. Meng , Bo Zhao

Multimodal large language models (MLLMs) have made significant strides, yet they face challenges in the medical domain due to limited specialized knowledge. While recent medical MLLMs demonstrate strong performance in lab settings, they…

Computation and Language · Computer Science 2024-10-22 Junda Wang , Yujan Ting , Eric Z. Chen , Hieu Tran , Hong Yu , Weijing Huang , Terrence Chen

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Multi-modal learning has significantly advanced generative AI, especially in vision-language modeling. Innovations like GPT-4V and open-source projects such as LLaVA have enabled robust conversational agents capable of zero-shot task…

Computation and Language · Computer Science 2024-06-17 Zekai Chen , Arda Pekis , Kevin Brown

With the rapid growth of large language models (LLMs) and vision-language models (VLMs) in medicine, simply integrating clinical text and medical imaging does not guarantee reliable reasoning. Existing multimodal models often produce…

Artificial Intelligence · Computer Science 2025-12-29 Zelin Zang , Wenyi Gu , Siqi Ma , Dan Yang , Yue Shen , Zhu Zhang , Guohui Fan , Wing-Kuen Ling , Fuji Yang

This study investigates whether diagnostic prompting can improve Multimodal Large Language Model (MLLM) reliability for visual complexity assessment of Amazon Search Results Pages (SRP). We compare diagnostic prompting with standard gestalt…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Divendar Murtadak , Yoon Kim , Trilokya Akula

With the proliferation of large language models (LLMs) in the medical domain, there is increasing demand for improved evaluation techniques to assess their capabilities. However, traditional metrics like F1 and ROUGE, which rely on token…

Computation and Language · Computer Science 2025-05-20 Xiechi Zhang , Zetian Ouyang , Linlin Wang , Gerard de Melo , Zhu Cao , Xiaoling Wang , Ya Zhang , Yanfeng Wang , Liang He

Machine learning (ML) applications in medical artificial intelligence (AI) systems have shifted from traditional and statistical methods to increasing application of deep learning models. This survey navigates the current landscape of…

Machine Learning · Computer Science 2024-01-23 Elisa Warner , Joonsang Lee , William Hsu , Tanveer Syeda-Mahmood , Charles Kahn , Olivier Gevaert , Arvind Rao

Multimodal large language models (MLLMs) have broadened the scope of AI applications. Existing automatic evaluation methodologies for MLLMs are mainly limited in evaluating queries without considering user experiences, inadequately…

Large Vision-Language Models (LVLMs) are capable of handling diverse data types such as imaging, text, and physiological signals, and can be applied in various fields. In the medical field, LVLMs have a high potential to offer substantial…

Pathological diagnosis remains the definitive standard for identifying tumors. The rise of multimodal large models has simplified the process of integrating image analysis with textual descriptions. Despite this advancement, the substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Xiaomin Wu , Rui Xu , Pengchen Wei , Wenkang Qin , Peixiang Huang , Ziheng Li , Lin Luo

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

Artificial Intelligence · Computer Science 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

Multimodal large language models (MLLMs) have demonstrated promise on publicly available dermatology benchmarks. However, benchmark performance may not generalize to real-world dermatologic decision-making. To quantify this…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Roy Jiang , Hyunjae Kim , Zhenyue Qin , Morten Lee , Margaret MacGibeny , Ailish Hanly , Angela Sadlowski , Shanin Chowdhury , Xuguang Ai , Jeffrey Gehlhausen , Qingyu Chen

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale…

Machine Learning · Computer Science 2025-03-21 Wei Dai , Peilin Chen , Malinda Lu , Daniel Li , Haowen Wei , Hejie Cui , Paul Pu Liang
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