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Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the…

Neurons and Cognition · Quantitative Biology 2015-05-05 Maurizio De Pittà , Nicolas Brunel , Andrea Volterra

Humans excel at continually acquiring, consolidating, and retaining information from an ever-changing environment, whereas artificial neural networks (ANNs) exhibit catastrophic forgetting. There are considerable differences in the…

Neural and Evolutionary Computing · Computer Science 2023-04-17 Fahad Sarfraz , Elahe Arani , Bahram Zonooz

Theories and models of working memory (WM) were at least since the mid-1990s dominated by the persistent activity hypothesis. The past decade has seen rising concerns about the shortcomings of sustained activity as the mechanism for…

Neurons and Cognition · Quantitative Biology 2023-04-14 Anders Lansner , Florian Fiebig , Pawel Herman

The study and understanding of human behaviour is relevant to computer science, artificial intelligence, neural computation, cognitive science, philosophy, psychology, and several other areas. Presupposing cognition as basis of behaviour,…

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

Neurons and Cognition · Quantitative Biology 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

In neuroscience, classical Hopfield networks are the standard biologically plausible model of long-term memory, relying on Hebbian plasticity for storage and attractor dynamics for recall. In contrast, memory-augmented neural networks in…

Neurons and Cognition · Quantitative Biology 2021-10-28 Danil Tyulmankov , Ching Fang , Annapurna Vadaparty , Guangyu Robert Yang

In machine learning, error back-propagation in multi-layer neural networks (deep learning) has been impressively successful in supervised and reinforcement learning tasks. As a model for learning in the brain, however, deep learning has…

Machine Learning · Computer Science 2016-12-19 Thomas Mesnard , Wulfram Gerstner , Johanni Brea

Spike-timing dependent plasticity (STDP) which observed in the brain has proven to be important in biological learning. On the other hand, artificial neural networks use a different way to learn, such as Back-Propagation or Contrastive…

Neural and Evolutionary Computing · Computer Science 2021-06-10 Shiyuan Li

By linking conceptual theories with observed data, generative models can support reasoning in complex situations. They have come to play a central role both within and beyond statistics, providing the basis for power analysis in molecular…

Methodology · Statistics 2022-08-15 Kris Sankaran , Susan P. Holmes

Probabilistic (p-) computing, which leverages the stochasticity of its building blocks (p-bits) to solve a variety of computationally hard problems, has recently emerged as a promising physics-inspired hardware accelerator platform. A…

Disordered Systems and Neural Networks · Physics 2025-05-02 Sagnik Banerjee , Shiva T. Konakanchi , Supriyo Datta , Pramey Upadhyaya

The discovery of neural plasticity has proved that throughout the life of a human being, the brain reorganizes itself through forming new neural connections. The formation of new neural connections are achieved through the brain's effort to…

Neurons and Cognition · Quantitative Biology 2020-08-10 Soaad Hossain

Humans can learn languages from remarkably little experience. Developing computational models that explain this ability has been a major challenge in cognitive science. Bayesian models that build in strong inductive biases - factors that…

Computation and Language · Computer Science 2023-05-25 R. Thomas McCoy , Thomas L. Griffiths

The classic paradigms for learning and memory recall focus on strengths of synaptic couplings and how these can be modulated to encode memories. In a previous paper [A. K. Behera, M. Rao, S. Sastry, and S. Vaikuntanathan, Physical Review X…

Disordered Systems and Neural Networks · Physics 2024-10-10 Agnish Kumar Behera , Matthew Du , Uday Jagadisan , Srikanth Sastry , Madan Rao , Suriyanarayanan Vaikuntanathan

Modern generative models demonstrate impressive capabilities, likely stemming from an ability to identify and manipulate abstract concepts underlying their training data. However, fundamental questions remain: what determines the concepts a…

Machine Learning · Computer Science 2024-12-12 Core Francisco Park , Maya Okawa , Andrew Lee , Hidenori Tanaka , Ekdeep Singh Lubana

The brain is believed to operate in part by making predictions about sensory stimuli and encoding deviations from these predictions in the activity of "prediction error neurons." This principle defines the widely influential theory of…

Neurons and Cognition · Quantitative Biology 2022-02-21 Vicky Zhu , Robert Rosenbaum

In exploring the simulation of human rhythmic perception and synchronization capabilities, this study introduces a computational model inspired by the physical and biological processes underlying rhythm processing. Utilizing a reservoir…

Neurons and Cognition · Quantitative Biology 2025-03-28 Zhongju Yuan , Wannes Van Ransbeeck , Geraint Wiggins , Dick Botteldooren

Binding kinetic parameters can be correlated with drug efficacy, which led to the development of various computational methods for predicting binding kinetic rates and gaining insight into protein-drug binding paths and mechanisms in recent…

Biomolecules · Quantitative Biology 2022-09-27 Farzin Sohraby , Ariane Nunes-Alves

The search for universal laws that help establish a relationship between dynamics and computation is driven by recent expansionist initiatives in biologically inspired computing. A general setting to understand both such dynamics and…

Machine Learning · Computer Science 2020-09-17 G Manjunath

Strongly coupled, recurrent, balanced network models have been successful in describing and predicting many phenomena observed in cortical neural recordings. However, most balanced network models use current-based synapse models in place of…

Neurons and Cognition · Quantitative Biology 2026-05-13 Vicky Zhu , Gabriel Ocker , Robert Rosenbaum

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar
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