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This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by The Insigneo Institute and The Knowledge Transfer Network. The BIOREME…

Objective: Evaluate a method for the estimation of the nocturnal systolic blood pressure (SBP) dip from 24-hour blood pressure trends using a wrist-worn photoplethysmography (PPG) sensor and a deep neural network in free-living individuals,…

This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by SofTMech and Innovate UK, Business Connect. The BIOREME network hosts…

Chronic Obstructive Pulmonary Disorder (COPD) is an irreversible and progressive disease which is highly heritable. Clinically, COPD is defined using the summary measures derived from a spirometry test but these are not always adequate.…

Machine Learning · Computer Science 2024-11-15 Soham Gadgil , Joshua Galanter , Mohammadreza Negahdar

Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes previously identified on autopsy. Unsupervised learning of emphysema subtypes on computed…

Computer Vision and Pattern Recognition · Computer Science 2020-07-10 Jie Yang , Elsa D. Angelini , Pallavi P. Balte , Eric A. Hoffman , John H. M. Austin , Benjamin M. Smith , R. Graham Barr , Andrew F. Laine

Respiratory illnesses are a significant global health burden. Respiratory illnesses, primarily Chronic obstructive pulmonary disease (COPD), is the seventh leading cause of poor health worldwide and the third leading cause of death…

Machine Learning · Computer Science 2024-10-31 Ankita Kumari Jain , Nitish Sharma , Madhav Kanda , Nipun Batra

Chronic Obstructive Pulmonary Disease (COPD), a major chronic respiratory disease with persistent airflow limitation, is a leading global cause of disability and mortality. Respiratory spirogram time series, routinely collected during…

Artificial Intelligence · Computer Science 2026-03-03 Shuhao Mei , Yongchao Long , Xiaoyu Xiao , Shan Cao , Xiaobo Han , Shijia Geng , Jinbo Sun , Yuxi Zhou , Shenda Hong

Objective: Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic condition. COPD is a major source of morbidity, mortality and healthcare costs. Spirometry is the gold standard test for a definitive diagnosis and…

Signal Processing · Electrical Eng. & Systems 2020-12-11 Jeremy Levy , Daniel Alvarez , Felix del Campo , Joachim A. Behar

Objective: To develop an algorithm that can infer the severity level of a COPD patient's airflow limitation from tidal breathing data that is collected by a wearable device. Methods: Data was collected from 25 single visit adult volunteers…

Signal Processing · Electrical Eng. & Systems 2021-04-27 Kofi Odame , Graham Atkins , Maria Nyamukuru , Katherine Fearon

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Current COPD diagnosis (i.e., spirometry) could be unreliable because the test depends on an adequate effort from the tester and testee. Moreover,…

Research significance: The extended version of this paper has been accepted by IEEE Internet of Things journal (DOI: 10.1109/JIOT.2020.2991456), please cite the journal version. During the epidemic prevention and control period, our study…

Machine Learning · Computer Science 2020-12-22 Yunlu Wang , Menghan Hu , Qingli Li , Xiao-Ping Zhang , Guangtao Zhai , Nan Yao

The COVID-19 pandemic has left a lasting impact on global healthcare systems, with increasing evidence of pulmonary fibrosis emerging as a post-infection complication. This study presents a comprehensive analysis of pulmonary fibrosis…

Other Quantitative Biology · Quantitative Biology 2023-09-22 John Martin , Hayder A. Albaqer , Fadhil G. Al-Amran , Habeeb W. Shubber , Salman Rawaf , Maitham G. Yousif

Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of hospitalizations, strongly associated with decreased survival, yet predicting the timing of these events remains challenging and has received limited…

Modeling disease progression in healthcare administrative databases is complicated by the fact that patients are observed only at irregular intervals when they seek healthcare services. In a longitudinal cohort of 76,888 patients with…

Machine Learning · Computer Science 2018-12-04 Aman Verma , Guido Powell , Yu Luo , David Stephens , David L. Buckeridge

Radiation therapy of thoracic and abdominal tumors requires incorporating the respiratory motion into treatments. To precisely account for the patient respiratory motions and predict the respiratory signals, a generalized model for…

Medical Physics · Physics 2019-05-22 Hui Lin , Chengyu Shi , Brian Wang , Maria F. Chan , Xiaoli Tang , Wei Ji

Large language models (LLMs) trained with next-word-prediction have achieved success as clinical foundation models. Representations from these language backbones yield strong linear probe performance across biomedical tasks, suggesting that…

Artificial Intelligence · Computer Science 2026-01-30 Irsyad Adam , Zekai Chen , David Laprade , Shaun Porwal , David Laub , Erik Reinertsen , Arda Pekis , Kevin Brown

Clinical investigations of anatomy's structural changes over time could greatly benefit from population-level quantification of shape, or spatiotemporal statistic shape modeling (SSM). Such a tool enables characterizing patient organ cycles…

Machine Learning · Computer Science 2022-09-08 Jadie Adams , Nawazish Khan , Alan Morris , Shireen Elhabian

Some patients with COVID-19 show changes in signs and symptoms such as temperature and oxygen saturation days before being positively tested for SARS-CoV-2, while others remain asymptomatic. It is important to identify these subgroups and…

Methodology · Statistics 2024-10-22 Xiaoran Ma , Wensheng Guo , Mengyang Gu , Len Usvyat , Peter Kotanko , Yuedong Wang

The COVID-19 pandemic's severe impact highlighted the need for accurate and timely hospitalization forecasting to support effective healthcare planning. However, most forecasting models struggled, particularly during variant surges, when…

Machine Learning · Computer Science 2025-07-17 Zhongying Wang , Thoai D. Ngo , Hamidreza Zoraghein , Benjamin Lucas , Morteza Karimzadeh

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

Computation and Language · Computer Science 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin
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