Related papers: A Multi-physics Model of Flow from Coronary Angiog…
The emergence of computational fluid dynamics (CFD) enabled the simulation of intricate transport processes, including flow in physiological structures, such as blood vessels. While these so-called hemodynamic simulations offer…
The limitations of conventional imaging techniques have hitherto precluded a thorough and formal investigation of the complex morphology of the left ventricular (LV) endocardial surface and its relation to the severity of Coronary Artery…
Accurate three-dimensional (3D) reconstruction of cardiac chamber motion from time-resolved medical imaging modalities is of growing interest in both the clinical and biomechanical fields. Despite recent advancement, the cardiac motion…
Hemodynamic quantities are valuable biomedical risk factors for cardiovascular pathology such as atherosclerosis. Non-invasive, in-vivo measurement of these quantities can only be performed using a select number of modalities that are not…
Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms of the ascending aorta. Both hemodynamic and genetic factors…
Coronary artery disease (CAD) stands as the leading cause of death worldwide, and invasive coronary angiography (ICA) remains the gold standard for assessing vascular anatomical information. However, deep learning-based methods encounter…
Several cardiovascular diseases are caused from localised abnormal blood flow such as in the case of stenosis or aneurysms. Prevailing theories propose that the development is caused by abnormal wall-shear stress in focused areas.…
X-ray Computed Tomography (CT) is used to recover the true surfaces of fluid channels and fed to simulation tool (ANSYS) to create accurate cyber environment. The simulation tool also receives CT-assisted multiphase fluid profiles…
The assessment of aortic valve pathology using magnetic resonance imaging (MRI) typically relies on blood velocity estimates acquired using phase contrast (PC) MRI. However, abnormalities in blood flow through the aortic valve often…
Physics-based 0D reduced-order models provide computationally lightweight predictions of cardiovascular flows, resolving bulk hemodynamics in fractions of a second that would take days to solve using traditional 3D finite-element…
Computer simulations of blood flow in patients with anomalous aortic origin of a coronary artery (AAOCA) have the promise to provide insight into this complex disease. They provide an in-silico experimental platform to explore possible…
Intrathecal (IT) injection is an effective way to deliver drugs to the brain bypassing the blood-brain barrier. To evaluate and optimize IT drug delivery, it is necessary to understand the cerebrospinal fluid (CSF) dynamics in the central…
At present, coronary angiography is the well known standard for the diagnosis of coronary artery disease. Conventional coronary angiography is an invasive procedure with a small, yet inherent risk of myocardial infarction, stroke, potential…
The clinical and economic burden of cardiovascular diseases (CVDs) poses a global challenge. Growing evidence suggests an early assessment of arterial stiffness can provide insights into the pathogenesis of CVDs. However, it remains…
Interest in the application of engineering methods to problems in congenital heart disease has gained increased popularity over the past decade. The use of computational simulation to examine common clinical problems including single…
We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…
Intracranial aneurysms (IAs) are serious cerebrovascular lesions found in approximately 5\% of the general population. Their rupture may lead to high mortality. Current methods for assessing IA risk focus on morphological and…
Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT…
Coronary artery disease, caused by the narrowing of coronary vessels due to atherosclerosis, is the leading cause of death worldwide. The diagnostic gold standard, fractional flow reserve (FFR), measures the trans-stenotic pressure ratio…
Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm…