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This article discusses the opportunities, applications and future directions of large-scale pre-trained models, i.e., foundation models, for analyzing medical images. Medical foundation models have immense potential in solving a wide range…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Shaoting Zhang , Dimitris Metaxas

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Spatio-temporal deep learning models aims to utilize useful patterns in such data to support tasks like prediction. However, previous deep learning models designed for specific tasks typically require separate training for each use case,…

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features…

Foundation models (FMs) have demonstrated strong transferability across medical imaging tasks, yet their clinical utility depends critically on how pretrained representations are adapted to domain-specific data, supervision regimes, and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

In computational pathology, several foundation models have recently emerged and demonstrated enhanced learning capability for analyzing pathology images. However, adapting these models to various downstream tasks remains challenging,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Jeaung Lee , Jeewoo Lim , Keunho Byeon , Jin Tae Kwak

This work addresses the problem of linear system realizations by mammillary models, offering necessary and sufficient conditions under which a given transfer function can be represented in this form. While standard identifi cation…

Optimization and Control · Mathematics 2025-07-15 Veronica Beltrami , Luca Consolini , Mattia Laurini , Marco Milanesi , Michele Schiavo , Antonio Visioli

Foundation models (FMs) are driving a prominent shift in biomedical imaging from task-specific models to unified backbone models for diverse tasks. This opens an avenue to integrate imaging, pathology, clinical records, and genomics data…

Quantitative Methods · Quantitative Biology 2026-04-23 Amgad Muneer , Kai Zhang , Ibraheem Hamdi , Rizwan Qureshi , Muhammad Waqas , Shereen Fouad , Hazrat Ali , Syed Muhammad Anwar , Jia Wu

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Multi-modal foundation models are typically trained on millions of pairs of natural images and text captions, frequently obtained through web-crawling approaches. Although such models depict excellent generative capabilities, they do not…

Computer Vision and Pattern Recognition · Computer Science 2023-01-03 Pierre Chambon , Christian Bluethgen , Curtis P. Langlotz , Akshay Chaudhari

Vision foundation models trained on discretely sampled images achieve strong performance on classification benchmarks, yet whether their representations encode the continuous processes underlying their training data remains unclear. This…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Pritika Vig , Ren-Chin Wu , William Lotter

The rapid advancement of foundation models in medical imaging represents a significant leap toward enhancing diagnostic accuracy and personalized treatment. However, the deployment of foundation models in healthcare necessitates a rigorous…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Congzhen Shi , Ryan Rezai , Jiaxi Yang , Qi Dou , Xiaoxiao Li

Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Praveenbalaji Rajendran , Mojtaba Safari , Wenfeng He , Mingzhe Hu , Shansong Wang , Jun Zhou , Xiaofeng Yang

Understanding material failure is critical for designing stronger and lighter structures by identifying weaknesses that could be mitigated. Existing full-physics numerical simulation techniques involve trade-offs between speed, accuracy,…

Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks,…

Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining…

Machine Learning · Computer Science 2024-10-23 Ching Fang , Christopher Sandino , Behrooz Mahasseni , Juri Minxha , Hadi Pouransari , Erdrin Azemi , Ali Moin , Ellen Zippi

Medical vision foundational models are used for a wide variety of tasks, including medical image segmentation and registration. This work evaluates the ability of these models to predict disease progression using a simple linear probe. We…

Image and Video Processing · Electrical Eng. & Systems 2025-03-24 Basar Demir , Soumitri Chattopadhyay , Thomas Hastings Greer , Boqi Chen , Marc Niethammer

Precision medicine in musculoskeletal imaging requires scalable measurement infrastructure. We developed a modular system that converts routine MRI into standardized quantitative biomarkers suitable for clinical decision support. Promptable…

Image and Video Processing · Electrical Eng. & Systems 2026-04-06 Gabrielle Hoyer , Michelle W Tong , Rupsa Bhattacharjee , Valentina Pedoia , Sharmila Majumdar

Foundation models (FMs) are rapidly reshaping medical imaging, shifting the field from narrowly trained, task-specific networks toward large, general-purpose models that can be adapted across modalities, anatomies, and clinical tasks. In…

Image and Video Processing · Electrical Eng. & Systems 2026-02-19 Chuang Niu , Pengwei Wu , Bruno De Man , Ge Wang

Medical image segmentation is vital for clinical diagnosis, yet current deep learning methods often demand extensive expert effort, i.e., either through annotating large training datasets or providing prompts at inference time for each new…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Xingjian Li , Qifeng Wu , Adithya S. Ubaradka , Yiran Ding , Colleen Que , Runmin Jiang , Jianhua Xing , Tianyang Wang , Min Xu
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