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Single-cell analysis is currently one of the most high-resolution techniques to study biology. The large complex datasets that have been generated have spurred numerous developments in computational biology, in particular the use of…

Genomics · Quantitative Biology 2023-04-27 Ionut Sebastian Mihai , Sarang Chafle , Johan Henriksson

What if large language models could not only infer human mindsets but also expose every blind spot in team dialogue such as discrepancies in the team members' joint understanding? We present a novel, two-step framework that leverages large…

Computation and Language · Computer Science 2025-09-03 Katharine Kowalyshyn , Matthias Scheutz

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

Large Language Models (LLMs) have recently shown remarkable ability to process not only text but also multimodal inputs such as speech and audio. However, most existing models primarily focus on analyzing input signals using text…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-20 Junyi Ao , Dekun Chen , Xiaohai Tian , Wenjie Feng , Jun Zhang , Lu Lu , Yuxuan Wang , Haizhou Li , Zhizheng Wu

Systematic reviews are crucial for synthesizing scientific evidence but remain labor-intensive, especially when extracting detailed methodological information. Large language models (LLMs) offer potential for automating methodological…

Computation and Language · Computer Science 2025-10-14 Wenqing Zhang , Trang Nguyen , Elizabeth A. Stuart , Yiqun T. Chen

Large language models (LLMs) have shown substantial progress in natural language understanding and generation, proving valuable especially in the medical field. Despite advancements, challenges persist due to the complexity and diversity…

Computation and Language · Computer Science 2024-10-18 Yusheng Liao , Shuyang Jiang , Zhe Chen , Yanfeng Wang , Yu Wang

Objectives: The vast and complex nature of human genomic sequencing data presents challenges for effective analysis. This review aims to investigate the application of Natural Language Processing (NLP) techniques, particularly Large…

Genomics · Quantitative Biology 2025-02-28 Shuyan Cheng , Yishu Wei , Yiliang Zhou , Zihan Xu , Drew N Wright , Jinze Liu , Yifan Peng

In the era of increasingly sophisticated natural language processing (NLP) systems, large language models (LLMs) have demonstrated remarkable potential for diverse applications, including tasks requiring nuanced textual understanding and…

Computation and Language · Computer Science 2025-05-16 Poli Apollinaire Nemkova , Solomon Ubani , Mark V. Albert

Instruction Tuning has the potential to stimulate or enhance specific capabilities of large language models (LLMs). However, achieving the right balance of data is crucial to prevent catastrophic forgetting and interference between tasks.…

Computation and Language · Computer Science 2024-03-07 Wenfeng Feng , Chuzhan Hao , Yuewei Zhang , Yu Han , Hao Wang

Automated text annotation is a compelling use case for generative large language models (LLMs) in social media research. Recent work suggests that LLMs can achieve strong performance on annotation tasks; however, these studies evaluate LLMs…

Computation and Language · Computer Science 2024-09-24 Nicholas Pangakis , Samuel Wolken

Tabular data is ubiquitous in real-world applications and abundant on the web, yet its annotation has traditionally required human labor, posing a significant scalability bottleneck for tabular machine learning. Our methodology can…

Machine Learning · Computer Science 2024-06-25 Yaojie Hu , Ilias Fountalis , Jin Tian , Nikolaos Vasiloglou

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Annotated data plays a critical role in Natural Language Processing (NLP) in training models and evaluating their performance. Given recent developments in Large Language Models (LLMs), models such as ChatGPT demonstrate zero-shot…

Computation and Language · Computer Science 2024-03-18 Minzhi Li , Taiwei Shi , Caleb Ziems , Min-Yen Kan , Nancy F. Chen , Zhengyuan Liu , Diyi Yang

Recent advances in Large Language Models (LLMs) have shown promise in automating discourse annotation for conversations. While manually designing tree annotation schemes significantly improves annotation quality for humans and models, their…

Computation and Language · Computer Science 2025-06-04 Kseniia Petukhova , Ekaterina Kochmar

Transcriptome foundation models TFMs hold great promises of deciphering the transcriptomic language that dictate diverse cell functions by self-supervised learning on large-scale single-cell gene expression data, and ultimately unraveling…

Machine Learning · Computer Science 2025-03-03 Xinyu Yuan , Zhihao Zhan , Zuobai Zhang , Manqi Zhou , Jianan Zhao , Boyu Han , Yue Li , Jian Tang

Accurate cell counting is essential in various biomedical research and clinical applications, including cancer diagnosis, stem cell research, and immunology. Manual counting is labor-intensive and error-prone, motivating automation through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Abdurahman Ali Mohammed , Catherine Fonder , Ying Wei , Wallapak Tavanapong , Donald S Sakaguchi , Qi Li , Surya K. Mallapragada

Large language models (LLMs) are increasingly used in sensitive domains, where their ability to infer personal data from seemingly benign text introduces emerging privacy risks. While recent LLM-based anonymization methods help mitigate…

Computation and Language · Computer Science 2025-10-27 Kyuyoung Kim , Hyunjun Jeon , Jinwoo Shin

Categorizing individual cells into one of many known cell type categories, also known as cell type annotation, is a critical step in the analysis of single-cell genomics data. The current process of annotation is time-intensive and…

Applications · Statistics 2021-11-25 Keshav Motwani , Rhonda Bacher , Aaron J. Molstad

Despite growing interest in using large language models (LLMs) to automate annotation, their effectiveness in complex, nuanced, and multi-dimensional labelling tasks remains relatively underexplored. This study focuses on annotation for the…

Information Retrieval · Computer Science 2025-07-02 Leila Tavakoli , Hamed Zamani